Volume 23 Issue 5
May  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(5): 819-822
ZHANG Aimu, LIU Sanwei, SHI Zhanhong, ZHOU Fan. Correlation analysis of anxiety and depression with bisphosphonate treatment compliance and bone mineral density changes in perimenopausal population[J]. Chinese Journal of General Practice, 2025, 23(5): 819-822. doi: 10.16766/j.cnki.issn.1674-4152.004009
Citation: ZHANG Aimu, LIU Sanwei, SHI Zhanhong, ZHOU Fan. Correlation analysis of anxiety and depression with bisphosphonate treatment compliance and bone mineral density changes in perimenopausal population[J]. Chinese Journal of General Practice, 2025, 23(5): 819-822. doi: 10.16766/j.cnki.issn.1674-4152.004009
shu

Correlation analysis of anxiety and depression with bisphosphonate treatment compliance and bone mineral density changes in perimenopausal population

doi: 10.16766/j.cnki.issn.1674-4152.004009

  • Department of Obstetrics and Gynecology, Wenzhou Central Hospital, Wenzhou, Zhejiang 325000, China

Funds:

 2024ZL997

 Y20210357

  • Received Date: 2024-06-05
    Available Online: 2025-08-14
    Abstract
  •   Objective  To analyze the correlation between anxiety and depression in the perimenopausal population, compliance with bisphosphonate treatment and changes in bone mineral density (BMD), and to provide evidence for early intervention of anxiety and depression in women.  Methods  A total of 248 perimenopausal women diagnosed and treated in Wenzhou Central Hospital from February 2022 to February 2024 were selected by convenient sampling method, and their anxiety and depression were evaluated by Zung self-rating anxiety scale (SAS) and Zung self-rating depression scale (SDS). According to the results, they were divided into an anxiety and depression group (SAS score ≥50 and SDS score ≥53) and a non-anxiety and depression group. The general data, bisphosphonate treatment compliance, and BMD of the two groups were analyzed and compared, and the related factors affecting the patients ' anxiety and depression were analyzed by multivariate logistic regression. At the same time, the anxiety and depression group was divided into mild, moderate, and severe according to the SAS score and SDS score. Pearson test was used to analyze the correlation between anxiety and depression scores and bisphosphonate treatment compliance, and BMD changes in perimenopausal women.  Results  Among the 245 perimenopausal patients who completed the investigation, 71 cases developed anxiety and depression, with an incidence rate of 28.98%. By multivariate logistic regression analysis, high BMI, no spouse, and high perimenopausal symptom severity score were independent risk factors for anxiety and depression in perimenopausal women, while no chronic disease, high medication compliance, and high BMD were independent protective factors for anxiety and depression in perimenopausal women. Anxiety score of perimenopausal women was negatively correlated with bisphosphonate treatment compliance and BMD changes.  Conclusion  The incidence of anxiety and depression in the perimenopausal population is high, which is negatively correlated with the compliance of bisphosphonate treatment and the change in BMD.

     

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