Volume 23 Issue 5
May  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(5): 810-813
ZHANG Jinna, WANG Lu, FENG Caiqin. Correlation between serum BDNF, mRNAs levels and pleasurable experience in young and middle-aged patients with schizophrenia[J]. Chinese Journal of General Practice, 2025, 23(5): 810-813. doi: 10.16766/j.cnki.issn.1674-4152.004007
Citation: ZHANG Jinna, WANG Lu, FENG Caiqin. Correlation between serum BDNF, mRNAs levels and pleasurable experience in young and middle-aged patients with schizophrenia[J]. Chinese Journal of General Practice, 2025, 23(5): 810-813. doi: 10.16766/j.cnki.issn.1674-4152.004007
shu

Correlation between serum BDNF, mRNAs levels and pleasurable experience in young and middle-aged patients with schizophrenia

doi: 10.16766/j.cnki.issn.1674-4152.004007
  • 1.

    Sixth Psychiatric, Shaoxing Seventh People's Hospital, Shaoxing, Zhejiang 312000, China

Funds:

 2024KY1736

 2024KY1735

 2020A13051

  • Received Date: 2024-10-20
    Available Online: 2025-08-14
    Abstract
  •   Objective  To analyze the correlation between serum brain-derived neurotrophic factor (BDNF), microRNA-21 (miRNA-21), and microRNA-181b (miRNA-181b) levels and pleasurable experience in young and middle-aged patients with schizophrenia, and to provide a theoretical basis for exploring the neurobiological mechanism underlying affective disorder in schizophrenia.  Methods  A total of 62 young and middle-aged patients with acute schizophrenia admitted to Shaoxing Seventh People ' s Hospital from April 2022 to June 2024 were selected as the case group. And 57 healthy individuals in the same period were selected as the control group. The scores of timed pleasurable experience scale (TEPS) and the levels of BDNF, miRNA-21, and miRNA-181b were measured and compared between the two groups. The correlations between TEPS scores and the above biomarkers in the case group were analyzed.  Results  The temporal experience of pleasure scale-anticipatory (TEPS-A) score in the case group (35.65±5.37) was significantly lower than that in the control group (41.35±4.49). The temporal experience of pleasure scale-consummatory (TEPS-C) score in the case group [29.00 (25.00, 33.00)] was significantly lower than that in the control group [36.00 (34.00, 38.50)]. The serum BDNF and miRNA-181b in the case group were significantly lower than those in the control group. Serum miRNA-21 [7.95 (7.46, 8.43)] was significantly higher than that in the control group [0.73 (0.52, 0.86)]. Spearman correlation analysis showed that TEPS-A score was positively correlated with serum BDNF (rs=0.782) and miRNA-181b (rs=0.649), and negatively correlated with miRNA-21 (rs=-0.755). TEPS-C score was positively correlated with serum BDNF (rs=0.789) and miRNA-181b (rs=0.715), and negatively correlated with miRNA-21 (rs=-0.671).  Conclusion  The levels of serum BDNF and mRNAs in young and middle-aged patients with schizophrenia were significantly positively correlated with pleasurable experience, suggesting their potential as quantitative indicators of pleasurable experience.

     

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