Volume 23 Issue 5
May  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(5): 794-797
JIN Yulan, WANG Jiao, HAN Yijiao, GONG Yuexian, ZHANG Ye. Study on therapeutic effect of modified Jichuanjian Decoction Jiawei on acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal function injury (constipation type due to yang deficiency)[J]. Chinese Journal of General Practice, 2025, 23(5): 794-797. doi: 10.16766/j.cnki.issn.1674-4152.004003
Citation: JIN Yulan, WANG Jiao, HAN Yijiao, GONG Yuexian, ZHANG Ye. Study on therapeutic effect of modified Jichuanjian Decoction Jiawei on acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal function injury (constipation type due to yang deficiency)[J]. Chinese Journal of General Practice, 2025, 23(5): 794-797. doi: 10.16766/j.cnki.issn.1674-4152.004003
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Study on therapeutic effect of modified Jichuanjian Decoction Jiawei on acute exacerbation of chronic obstructive pulmonary disease complicated with gastrointestinal function injury (constipation type due to yang deficiency)

doi: 10.16766/j.cnki.issn.1674-4152.004003
  • 1.

    Department of Critical Care Medicine, Dongyang Hospital of Traditional Chinese Medicine, Dongyang, Zhejiang 322100, China

Funds:

 2023KY681

 2023-4-238

  • Received Date: 2024-04-10
    Available Online: 2025-08-14
    Abstract
  •   Objective  To explore the clinical efficacy and safety of Jichuanjian Decoction Jiawei in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with acute gastrointestinal function injury (AGI, constipation type due to yang deficiency).  Methods  Eighty patients with AECOPD complicated with AGI (constipation type due to yang deficiency) admitted to intensive care unit (ICU) of Dongyang Hospital of Traditional Chinese Medicine from July 2022 to December 2023, and they were divided into routine group (routine treatment of western medicine) and research group (addition of Jichuanjian Decoction Jiawei on the basis of routine group) according to the treatment methods, with 40 patients in each group. The comprehensive curative effect of AGI and gastrointestinal indexes were compared between groups.  Results  The comprehensive curative rate of AGI in the study group [87.50% (35/40)] was significantly higher than that in the routine group [60.00% (24/40), P < 0.05]. After 7 days of treatment, the intra-abdominal pressure and gastric residue in the study group were lower than those in the routine group, and the bowel sounds were higher than those in the routine group (P < 0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6) in the study group were lower than those in the routine group, and the scores of constipation, abdominal distension, cold limbs, and mental fatigue were lower than those in the routine group (P < 0.05). There was no significant difference in adverse reaction rate between the study group and the routine group [10.00% (4/40) vs.7.50% (3/40), P>0.05].  Conclusion  Treating AECOPD with AGI (constipation type due to yang deficiency) with Jichuanjian Decoction is helpful to improve the comprehensive curative effect of GI, improve gastrointestinal indicators and inflammatory factors, and relieve constipation, abdominal distension, cold limbs, and mental fatigue, with good security.

     

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