Volume 23 Issue 4
Apr.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(4): 613-617
WU Jie, CHEN Xin, MAO Huifang, CHENG Jin, WEI Suo, WANG Lihua. Investigation of quality of life in Duchenne muscular dystrophy children in Anhui Province and analysis of influencing factors[J]. Chinese Journal of General Practice, 2025, 23(4): 613-617. doi: 10.16766/j.cnki.issn.1674-4152.003963
Citation: WU Jie, CHEN Xin, MAO Huifang, CHENG Jin, WEI Suo, WANG Lihua. Investigation of quality of life in Duchenne muscular dystrophy children in Anhui Province and analysis of influencing factors[J]. Chinese Journal of General Practice, 2025, 23(4): 613-617. doi: 10.16766/j.cnki.issn.1674-4152.003963
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Investigation of quality of life in Duchenne muscular dystrophy children in Anhui Province and analysis of influencing factors

doi: 10.16766/j.cnki.issn.1674-4152.003963
  • 1.

    Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 2022zmgj018

  • Received Date: 2024-07-11
    Available Online: 2025-06-30
    Abstract
  •   Objective  To investigate the oral health-related quality of life and associated factors in children with Duchenne muscular dystrophy (DMD) in Anhui province, providing reference for improving the quality of life in this population and developing relevant health management systems.  Methods  A cross-sectional survey was adopted to select the children with Duchenne muscular dystrophy who met the criteria in Anhui Province from February to August 2023. The pediatric quality of life inventory measurement models (PedsQL) was used to investigate the quality of life of DMD patients, and multiple liner regression analysis was used to explore the factors influencing quality of life scores in DMD patients.  Results  A total of 179 valid questionnaires were collected, with an effective response rate of 90.40%. The average age at diagnosis was 3.00 (2.00, 5.00) years old, with a misdiagnosis rate of 41.90% (75/179) and a long-distance treatment rate of 69.27% (124/179). In addition, the PedsQL quality of life score for children was (42.22±20.38) points. The patient health questionnaire-9 (PHQ-9) showed that 77.65% (139/179) of participants exhibited depressive tendencies. Multiple linear regression analysis identified age, primary place of residence, receipt of hormone therapy, and caregiver depression as significant factors influencing quality of life scores in children with DMD (P < 0.05).  Conclusion  There is still significant potential for improving the quality of life for children with DMD in Anhui Province. The quality of life is influenced by factors such as patient' s place of residence, hormone therapy, and the caregiver' s feelings of depression. Proactive measures should be taken to improve the quality of life for DMD patients, strengthen education on disease prevention and management, and provide humanistic care.

     

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