Volume 23 Issue 1
Jan.  2025
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JIANG Junjie, SHENG Chenwei. Correlation between the dynamic analysis of D-dimer levels and post-treatment ultrasonic characteristics in patients with venous thrombosis of lower limbs[J]. Chinese Journal of General Practice, 2025, 23(1): 111-114. doi: 10.16766/j.cnki.issn.1674-4152.003847
Citation: JIANG Junjie, SHENG Chenwei. Correlation between the dynamic analysis of D-dimer levels and post-treatment ultrasonic characteristics in patients with venous thrombosis of lower limbs[J]. Chinese Journal of General Practice, 2025, 23(1): 111-114. doi: 10.16766/j.cnki.issn.1674-4152.003847
shu

Correlation between the dynamic analysis of D-dimer levels and post-treatment ultrasonic characteristics in patients with venous thrombosis of lower limbs

doi: 10.16766/j.cnki.issn.1674-4152.003847
  • 1.

    Department of Special inspection Division, Huzhou Third People' s Hospital, Huzhou, Zhejiang 313000, China

Funds:

 2021KY1098

  • Received Date: 2024-01-09
    Available Online: 2025-02-13
    Abstract
  •   Objective  To detect the level of D-dimer in patients with venous thrombosis of lower limbs and analyze the relationship between the ultrasonic characteristics of patients after treatment and the dynamic changes in D-dimer level.  Methods  One hundred and twenty-seven patients with deep venous thrombosis of lower limbs who received anticoagulant therapy at the Huzhou Third People' s Hospital from June 2020 to March 2022 were selected retrospectively. D-dimer levels were recorded before and after treatment. According to the recurrence of venous thromboembolism in lower limbs during follow-up, patients were divided into a recurrence group and a non-recurrence group. The correlation between the dynamic changes in D-dimer levels, the ultrasonic characteristics after treatment, and the time point of recurrence risk was analyzed.  Results  Of the 127 patients, 34 were included in the recurrence group, and the remaining 93 patients were included in the non-recurrence group. FV [(8.53±1.51) cm/s] and other ultrasonic blood flow signal values in the recurrence group were lower than those in the non-recurrence group [(19.79±5.29) cm/s, t=12.231, P < 0.001]. Six months after treatment, D-dimer levels were negatively correlated with the ultrasonic blood flow signal values of FV (r=-0.499, P < 0.001), CIV (r=-0.588, P < 0.001), and POV (r=-0.538, P < 0.001). The differences in D-dimer levels at 6, 9, and 12 months after treatment had statistical significances for the recurrence risk of venous thromboembolism in lower limbs (P < 0.05).  Conclusion  The dynamic changes of D-dimer levels can monitor the recurrence risk in patients with venous thrombosis of lower limbs after anticoagulation treatment. After 3 months of anticoagulation treatment, monitoring for abnormal increase in D-dimer levels is crucial, and extending the duration of anticoagulation treatment may help prevent the recurrence of lower-limb venous thrombosis.

     

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