Volume 22 Issue 11
Nov.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1917-1920
XING Lili, FAN Shuyu, YU Hongxia, CAO Ning. Application of uterine artery flow parameters combined with serum alpha-fetoprotein in predicting premature birth in twins[J]. Chinese Journal of General Practice, 2024, 22(11): 1917-1920. doi: 10.16766/j.cnki.issn.1674-4152.003764
Citation: XING Lili, FAN Shuyu, YU Hongxia, CAO Ning. Application of uterine artery flow parameters combined with serum alpha-fetoprotein in predicting premature birth in twins[J]. Chinese Journal of General Practice, 2024, 22(11): 1917-1920. doi: 10.16766/j.cnki.issn.1674-4152.003764
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Application of uterine artery flow parameters combined with serum alpha-fetoprotein in predicting premature birth in twins

doi: 10.16766/j.cnki.issn.1674-4152.003764
  • 1.

    Ultrasound Department, the Seventh People' s Hospital of Zhengzhou, Zhengzhou, Henan 450014, China

Funds:

 LHGJ20210361

  • Received Date: 2023-11-20
    Available Online: 2024-12-31
    Abstract
  •   Objective  Preterm birth (PTB) is the main cause of neonatal death. Twins at high risk of PTB are susceptible to placental barrier rupture and fetal blood flow entering the mother, resulting in an increase in maternal serum alpha-fetoprotein (AFP) levels. The purpose of this study was to explore the predictive value of combining uterine artery blood flow parameters with AFP levels in predicting preterm delivery in twins.  Methods  A total of 100 pregnant women with twin pregnancy who underwent regular antenatal examination in the Seventh People' s Hospital of Zhengzhou from January 2015 to April 2021 were retrospectively analyzed. According to the pregnancy outcome, they were divided into a premature group (n=51) and a term group (n=49). Differences in mid-pregnancy serum AFP levels and uterine artery blood flow parameters were compared through repeated measurement analysis of variance. The predictive value of these factors for premature birth outcomes in twin pregnancies was assessed through logistic regression analysis.  Results  As progression of pregnancy, uterine artery pulsatility index (uterine artery pulsation index, PI), uterine artery resistance index (uterine artery resistance index, RI), and uterine artery blood flow Scarlett D value decreased, while serum AFP level increased gradually in both the preterm group and term group. The uterine artery hemodynamic parameters and serum AFP levels in the preterm group were higher than those in the term group at various gestational weeks. The AUC values of serum AFP, PI, RI, S/D and their combination were 0.952, 0.881, 0.903, 0.919 and 0.966, respectively. Logistic regression analysis showed that serum AFP, PI, RI and S/D were risk factors for preterm delivery in twin pregnant women (OR=2.746, 1.262, 1.509 and 2.158, respectively).  Conclusion  The combination of serum AFP levels, PI, RI, and S/D values can effectively predict premature delivery in twin birth, improving the sensitivity and specificity compared to single indicators.

     

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