Volume 21 Issue 11
Nov.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(11): 1845-1848
XING Benyuan, DAI Xinyu, DING Hong, NIAN Fujia, PENG Gang, LI Yuntao. Correlation between inflammatory response and peripheral blood platelet-lymphocyte ratio and vitelliform degeneration in human carotid atherosclerotic plaques[J]. Chinese Journal of General Practice, 2023, 21(11): 1845-1848. doi: 10.16766/j.cnki.issn.1674-4152.003239
Citation: XING Benyuan, DAI Xinyu, DING Hong, NIAN Fujia, PENG Gang, LI Yuntao. Correlation between inflammatory response and peripheral blood platelet-lymphocyte ratio and vitelliform degeneration in human carotid atherosclerotic plaques[J]. Chinese Journal of General Practice, 2023, 21(11): 1845-1848. doi: 10.16766/j.cnki.issn.1674-4152.003239
shu

Correlation between inflammatory response and peripheral blood platelet-lymphocyte ratio and vitelliform degeneration in human carotid atherosclerotic plaques

doi: 10.16766/j.cnki.issn.1674-4152.003239
  • 1.

    Department of General Practice, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China

Funds:

 M2022045

  • Received Date: 2023-07-07
    Abstract
  •   Objective  To investigate the correlation between inflammatory response and peripheral blood platelet-lymphocyte ratio (PLR) and vitreous degeneration in human carotid atherosclerotic plaques, and to provide a new basis for further diagnosis and treatment of atherosclerosis.  Methods  Thirty-nine patients with atherosclerosis of the internal carotid artery system treated by carotid endarterectomy in the Department of Neurosurgery, the Second Affiliated Hospital of Nanjing Medical University from October 2018 to April 2022 were retrospectively and consecutively included. The 39 resected carotid atherosclerotic plaque specimens were examined by histopathology, and the patients were divided into inflammatory response group and non-inflammatory response group, and vitreous degeneration and non-vitreous degeneration groups, and the patients' peripheral blood lymphocyte and platelet counts were recorded, and routine blood examination indices such as PLR were calculated to analyze the relationship between the inflammatory response in carotid atherosclerosis and PLR and the degree of vitreous degeneration.  Results  A total of 39 patients were included, including 23 patients with carotid atherosclerotic plaque with inflammatory response and 32 patients with hyaline degeneration. Compared with the general information for the non-inflammatory response group, the PLR value of the inflammatory response group [135.93 (124.24, 169.15)] was significantly higher than that of the non-inflammatory response group [112.53 (101.95, 123.39)], and the difference between the two groups was statistically significant (P=0.002); the difference between plaque inflammatory response and hyaline degeneration is statistically significant (P=0.035).  Conclusion  In carotid atherosclerosis, the PLR is increased in patients with high plaque inflammatory response, and there is a positive correlation between intraplaque inflammatory response and plaque vitreous degeneration. Therefore, measuring PLR levels in patients' blood and monitoring changes in both intraplaque inflammatory response and plaque vitreous degeneration levels may provide a new basis for clinical diagnosis, treatment and prevention of atherosclerosis.

     

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