Research progress in the pathogenesis and treatment of chronic prostatitis associated with intestinal microbiota dysregulation

XU Xinyu; CUI Yun; WU Jun

doi:10.16766/j.cnki.issn.1674-4152.003213

Volume 21 Issue 10

Oct. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(10): 1736-1740

XU Xinyu, CUI Yun, WU Jun. Research progress in the pathogenesis and treatment of chronic prostatitis associated with intestinal microbiota dysregulation[J]. Chinese Journal of General Practice, 2023, 21(10): 1736-1740. doi: 10.16766/j.cnki.issn.1674-4152.003213

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XU Xinyu, CUI Yun, WU Jun. Research progress in the pathogenesis and treatment of chronic prostatitis associated with intestinal microbiota dysregulation[J]. Chinese Journal of General Practice, 2023, 21(10): 1736-1740. doi: 10.16766/j.cnki.issn.1674-4152.003213

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Research progress in the pathogenesis and treatment of chronic prostatitis associated with intestinal microbiota dysregulation

doi: 10.16766/j.cnki.issn.1674-4152.003213

XU Xinyu¹
, CUI Yun^{2
,
,}
, WU Jun²

1.
The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

Funds:

LY21H270015

国中医药人教函[2022]75号

2022ZB337

2022ZB311

PPXK2018-07

Received Date: 2022-11-17
Available Online: 2023-11-23

Abstract

Abstract

Chronic prostatitis (CP) is a common and frequent disease in urology. Typical performance are mental symptoms (anxiety, depression, cognitive and behavioral abnormalities, lower quality of life), pelvic pain symptoms (urogenital area pain, abdominal and pelvic muscle tenderness, ejaculatory pain, painful urination) symptoms, sexual dysfunction (impotence, low sexual desire, ejaculatory dysfunction), as well as the urinary tract symptoms (frequent urination, urinary urgency, increased nocturia, posturinary leaking, dysuria, etc.). Modern medicine believes that the pathogenesis of CP is closely related to immune disorders, endocrine disorders and local microcirculation disorders, but the core pathogenesis is still unclear. Intestinal microbiota is closely related to human health. In recent years, domestic and foreign scholars have increasingly studied the relationship between gut microbiota and CP, which provides a new perspective for revealing the mechanism of CP. The dysregulation of gut microbiota induces CP mental and psychological symptoms by mediating the increase of inflammatory factors, the hyperactivity of hypothalamic-pituitary-adrenal then disturb hormone level and the abnormal function of neurotransmitters, and induces CP pelvic pain symptoms by inducing the release of inflammatory factors, the sensitization of dorsal root ganglion neurons and the activation of brain glial cells. It can lead to sexual dysfunction symptoms by affecting the levels of testosterone and neurotransmitters, and lead to CP lower urinary tract symptoms by direct infection and affecting the function of pelvic floor muscles. It has become a new direction of CP treatment to restore intestinal microbiota homeostasis by increasing beneficial bacteria and reducing harmful bacteria. At present, probiotics and prebiotics such as oligosaccharides, protein hydrolysates and traditional Chinese medicine polysaccharides are mainly used to regulate intestinal microbiota in the treatment of CP, which has achieved remarkable results and opened up a new direction of CP diagnosis and treatment. This article reviews the pathogenesis and treatment of chronic prostatitis related to intestinal microbiota dysregulation at home and abroad, in order to provide new ideas and basis for urologists to diagnose and treat CP.
- Intestinal microbiota,
- Chronic prostatitis,
- Probiotics,
- Plant polysaccharides,
- Neurotransmitter

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References(35)

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Research progress in the pathogenesis and treatment of chronic prostatitis associated with intestinal microbiota dysregulation

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Research progress in the pathogenesis and treatment of chronic prostatitis associated with intestinal microbiota dysregulation

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