Volume 21 Issue 10
Oct.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1693-1697
SHEN Bianhong, WANG Chengpeng, GAO Kerun, ZHANG Kaiyuan, ZHANG Zhiwen, ZHU Chunyan, FANG Ling, TANG Jianping. Analysis of factors influencing liver injury caused by long-term use of second-generation antipsychotics in patients with schizophrenia[J]. Chinese Journal of General Practice, 2023, 21(10): 1693-1697. doi: 10.16766/j.cnki.issn.1674-4152.003203
Citation: SHEN Bianhong, WANG Chengpeng, GAO Kerun, ZHANG Kaiyuan, ZHANG Zhiwen, ZHU Chunyan, FANG Ling, TANG Jianping. Analysis of factors influencing liver injury caused by long-term use of second-generation antipsychotics in patients with schizophrenia[J]. Chinese Journal of General Practice, 2023, 21(10): 1693-1697. doi: 10.16766/j.cnki.issn.1674-4152.003203
shu

Analysis of factors influencing liver injury caused by long-term use of second-generation antipsychotics in patients with schizophrenia

doi: 10.16766/j.cnki.issn.1674-4152.003203

  • Department of Psychiatry, Hangzhou Seventh People's Hospital (Affiliated Mental Health Center of Zhejiang University School of Medicine), Hangzhou, Zhejiang 310013, China

Funds:

 2021RC025

 2019RC073

  • Received Date: 2023-05-26
    Available Online: 2023-11-23
    Abstract
  •   Objective  A retrospective study was conducted to investigate the risk factors for liver dysfunction associated with long-term use of paliperidone, ziprasidone and other second-generation antipsychotics in patients with schizophrenia.  Methods  A retrospective study was conducted on 120 patients with schizophrenia who were on long-term second-generation antipsychotics in Hangzhou Seventh People's Hospital from April 2021 to April 2023. They were divided into 2 groups according to whether they had liver injury or not. Thirty-six patients with liver injury were set as the observation group, and 84 patients without liver injury were set as the control group. The risk factors of liver injury were investigated by univariate and multivariate logistic regression analysis. Combined with the results of logistic regression analysis results, R software was used to build a nomogram prediction model for predicting liver injury caused by long-term use of second-generation antipsychotics in schizophrenia patients, and the receiver operating curve (ROC) was plotted, the area under the curve (AUC) was calculated, and the predictive ability of this model was analyzed.  Results  Logistic regression analysis showed that disease duration >10 years, history of liver disease, history of alcohol consumption, malnutrition, tuberculosis and type of antipsychotic drugs ≥3 were risk factors for long-term use of second-generation antipsychotics in schizophrenia patients (P < 0.05). Hosmer-Lemeshow goodness of fit test, χ2=3.049, P=0.405; C-index=0.910; AUC was 0.910 (95% CI: 0.804-0.946).  Conclusion  Influencing factors for liver injury induced by long-term use of second-generation antipsychotics in schizophrenia patients were disease duration, and risk factors included liver disease history, alcohol consumption, malnutrition, tuberculosis and type of antipsychotics ≥3 types. The prediction model had a high predictive power.

     

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