Volume 21 Issue 9
Sep.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(9): 1491-1494
CHEN Changxi, DU Juan, SONG Jian, ZHANG Cheng, LI Mengting, LI Hongliang. Study on correlation between serum hypersensitive C-reactive protein and nonalcoholic fatty liver disease in the elderly[J]. Chinese Journal of General Practice, 2023, 21(9): 1491-1494. doi: 10.16766/j.cnki.issn.1674-4152.003153
Citation: CHEN Changxi, DU Juan, SONG Jian, ZHANG Cheng, LI Mengting, LI Hongliang. Study on correlation between serum hypersensitive C-reactive protein and nonalcoholic fatty liver disease in the elderly[J]. Chinese Journal of General Practice, 2023, 21(9): 1491-1494. doi: 10.16766/j.cnki.issn.1674-4152.003153
shu

Study on correlation between serum hypersensitive C-reactive protein and nonalcoholic fatty liver disease in the elderly

doi: 10.16766/j.cnki.issn.1674-4152.003153
  • 1.

    Department of Gastroenterology, the Affiliated People' s Hospital of Ningbo University, Ningbo, Zhejiang 315000, China

Funds:

 2022KY1182

 2017A610276

 2021AS0053

  • Received Date: 2023-02-03
    Available Online: 2023-10-19
    Abstract
  •   Objective  To investigate the relationship between serum hypersensitive C-reactive protein (hs-CRP) and nonalcoholic fatty liver disease (NAFLD) in the elderly, and provide the basis for prevention and treatment of NAFLD.  Methods  A total of 2 124 senior citizens aged 60 and above in a petrochemical enterprise in Zhenhai District, Ningbo City were investigated from March to November 2013, and their waist circumference, body mass index, blood pressure, fasting blood glucose, uric acid, blood lipid profile, liver function, hs-CRP and upper abdominal B-ultrasound were measured. Groups were categorized by quartiles of hs-CRP levels as follows: group Q1 (≤0.4 mg/L, n=667), Q2 (>0.4 mg/L-≤0.7 mg/L, n=437), Q3 (>0.7 mg/L-≤1.4 mg/L, n=515), and Q4(>1.4 mg/L, n=505). The risk factors of NAFLD were analyzed by logistic regression.  Results  The prevalence of NAFLD in the elderly was 25.8% (548/2 124), and with the growth of age, the prevalence rate gradually decreases (P < 0.05). The prevalence of NAFLD in Q1, Q2, Q3 and Q4 groups were 13.2%(88/667), 24.5%(107/437), 32.6%(168/515) and 36.6% (185/505), respectively, and the prevalence gradually increased (χ2=99.246, P < 0.001). Multivariate unconditional logistic regression analysis showed that elevated serum hs-CRP was an independent risk factor for NAFLD in the elderly. The prevalence of NAFLD in Q2, Q3 and Q4 groups before the adjustment of the relevant factors were 2.133, 3.185, 3.804 times of Q1, and 1.554, 1.828, 1.895 times of Q1 group after the adjustment of the relevant factors.  Conclusion  Elevated serum hs-CRP is an independent risk factor for NAFLD in the elderly.

     

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