Volume 21 Issue 9
Sep.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(9): 1453-1456
LI Yu, XIANG Ping, KONG Lingquan, HUANG Tao. Clinical diagnosis, treatment and analysis of 71 cases of chromophobe renal cell carcinoma in a single center[J]. Chinese Journal of General Practice, 2023, 21(9): 1453-1456. doi: 10.16766/j.cnki.issn.1674-4152.003144
Citation: LI Yu, XIANG Ping, KONG Lingquan, HUANG Tao. Clinical diagnosis, treatment and analysis of 71 cases of chromophobe renal cell carcinoma in a single center[J]. Chinese Journal of General Practice, 2023, 21(9): 1453-1456. doi: 10.16766/j.cnki.issn.1674-4152.003144
shu

Clinical diagnosis, treatment and analysis of 71 cases of chromophobe renal cell carcinoma in a single center

doi: 10.16766/j.cnki.issn.1674-4152.003144

  • Department of Urology, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, Anhui 230001, China

Funds:

 2022AH051256

  • Received Date: 2023-06-04
    Available Online: 2023-10-19
    Abstract
  •   Objective  To investigate the clinical features, pathological features, surgical efficacy and prognosis of chromophobe renal cell carcinoma (chRCC), and to improve the level of diagnosis and treatment of this disease.  Methods  Clinical and follow-up data of 71 patients with chRCC from the First Affiliated Hospital of University of Science and Technology of China from June 2015 to March 2023 were retrospectively analyzed. Clinical experience was summarized. Meanwhile, the perioperative indexes of the partial nephrectomy (PN) group and the radical nephrectomy (RN) group were compared.  Results  There were 26 cases of PN and 45 cases of RN in 71 patients with chRCC. There were 24 cases of T1a, 31 cases of T1b, 12 cases of T2a, and 4 cases of T2b. CT mainly showed isodense or slightly low-density solid space occupying in the kidney, light and moderate enhancement in the arterial phase, and the enhancement degree was lower than the renal parenchyma, showing a slowly increasing state, and the enhancement degree in the venous phase and the delayed phase slowly decreased. Among 65 cases, 61 cases were positive for CD117 staining, and 1 case was weakly positive. Among 69 cases, 62 cases were positive for CK7 staining, and 1 case was weakly positive. Vimentin staining was negative in 54 of 60 cases. Among 44 cases, 33 were positive for colloidal iron staining and 8 were weakly positive. Seventy cases of Ki-67 were all positive, with a median Ki-67 value of 4.5%. There were no statistically significant differences in age, preoperative creatinine clearance (Ccr), intraoperative blood loss, postoperative hemoglobin decline, postoperative albumin decline, drainage indent time and postoperative hospital stay between PN and RN groups (all P > 0.05). The postoperative Ccr in PN group was significantly better than that in RN group, and the maximum tumor diameter and T stage in PN group were lower than those in RN group (all P < 0.05). Sixty-eight patients were followed up successfully, and all of them were tumor free until the end of follow-up.  Conclusion  chRCC is a rare, low malignant and low invasive subtype of renal cell carcinoma with good prognosis. It has unique CT imaging findings and can be confirmed by routine pathology and immunohistochemistry. PN is superior to RN in renal function protection, and PN is a safe and effective surgical method for treating chRCC at T1 stage.

     

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