Volume 21 Issue 8
Aug.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(8): 1329-1331
YU Liting, XU Xunhong, JIANG Wenming, YU Yongmiao. Prognosis value of liquid chip detection of cytokines in patients with acute organophosphorus pesticide poisoning[J]. Chinese Journal of General Practice, 2023, 21(8): 1329-1331. doi: 10.16766/j.cnki.issn.1674-4152.003115
Citation: YU Liting, XU Xunhong, JIANG Wenming, YU Yongmiao. Prognosis value of liquid chip detection of cytokines in patients with acute organophosphorus pesticide poisoning[J]. Chinese Journal of General Practice, 2023, 21(8): 1329-1331. doi: 10.16766/j.cnki.issn.1674-4152.003115
shu

Prognosis value of liquid chip detection of cytokines in patients with acute organophosphorus pesticide poisoning

doi: 10.16766/j.cnki.issn.1674-4152.003115

  • Department of Emergency, Chun'an Branch of Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 311700, China

Funds:

 2023XY144

  • Received Date: 2023-01-28
    Available Online: 2023-09-13
    Abstract
  •   Objective  To evaluate the prognostic value of serum cytokines in patients with acute organophosphorus pesticide poisoning (AOPP) by liquid chip technique.  Methods  A total of 80 patients with moderate to severe AOPP admitted to Chun ' an Branch of Zhejiang Provincial People ' s Hospital from April 2019 to June 2022 were selected as the study subjects. The related serum cytokines were detected by liquid chip technology. According to the prognosis, the patients were divided into survival group (61 cases) and death group (19 cases). General data and serum cytokine levels were compared between the two groups, and ROC curve was drawn to evaluate the prognostic efficacy of related influencing factors.  Results  APACHE Ⅱ score (27.89±4.00) in death group was higher than that in survival group (21.50±2.90, P < 0.05). The levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, salivary liquiform glycogen-6 (KL-6), transforming growth factor-β (TGF-β) and troponin I (cTnI) in death group were higher than those in survival group (P < 0.05). ROC curve showed that the AUC of cTnI, IL-6, KL-6, TNF-α and TGF-β for prognosis were 0.805 (95% CI: 0.702-0.885), 0.755 (95% CI: 0.656-0.844) and 0.682 (95% CI: 0.569-0.782), 0.751 (95% CI: 0.642-0.841), 0.716 (95% CI: 0.604-0.811), which were no statistical significance compared with the AUC predicted by APACHE Ⅱ score [(0.890, 95% CI: 0.800-0.949), P>0.05].  Conclusion  Liquid chip is an effective method to detect a variety of cytokines, and the TNF-α, IL-6, KL-6, cTnI, TGF-β1 cytokines detected by this technology have high prognostic value for AOPP.

     

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