Volume 21 Issue 8
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(8): 1271-1274
LIU Zhengyu, XU Liang. Analysis of clinical characteristics and diagnostic and treatment of 51 cases of late-onset systemic lupus erythematosus[J]. Chinese Journal of General Practice, 2023, 21(8): 1271-1274. doi: 10.16766/j.cnki.issn.1674-4152.003100
Citation: LIU Zhengyu, XU Liang. Analysis of clinical characteristics and diagnostic and treatment of 51 cases of late-onset systemic lupus erythematosus[J]. Chinese Journal of General Practice, 2023, 21(8): 1271-1274. doi: 10.16766/j.cnki.issn.1674-4152.003100
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Analysis of clinical characteristics and diagnostic and treatment of 51 cases of late-onset systemic lupus erythematosus

doi: 10.16766/j.cnki.issn.1674-4152.003100

  • Department of Rheumatology, the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China

Funds:

 30571740

  • Received Date: 2023-05-18
    Abstract
  •   Objective  To compare the epidemiology, clinical manifestations, laboratory tests, and treatment protocols of late-onset systemic lupus erythematosus (LSLE) and adult onset systemic lupus erythematosus (ASLE), and to explore the clinical features and diagnostic and therapeutic characteristics of LSLE.  Methods  The medical records of 170 patients with systemic lupus erythematosus (SLE) who were initially diagnosed and treated in the First Affiliated Hospital of Wannan Medical College from September 2017 to June 2022 were retrospectively analyzed. According to the age of onset, patients were divided into two groups: ≥50 years old was the LSLE group (51 cases); < 50 years old was in the ASLE group (119 cases).  Results  Compared with the ASLE group, the time from onset to diagnosis was significantly longer in the LSLE group [3.0 (1.0, 12.0) months vs. 1.0 (0.5, 5.0) months, Z=-3.391, P=0.001], there was a significant increase in the percentage of patients with more than one disease at the time of diagnosis, a significant decrease in fever, rash, and photosensitivity, a significant increase in the percentage of patients with dry syndrome, a significant decrease in the incidence of leukopenia and hypocomplementemia, a significant decrease in the incidence of positive anti-d-DNA and anti-sm antibodies, and a significant decrease in the SLEDAI-2000 and BILAG-2004 scores. After the LSLE group completed the disease activity assessment, the maximum average dose of glucocorticoids and the rate of glucocorticoid use were significantly reduced. The use rate of immunosuppressants and the types of immunosuppressants used were significantly reduced, and the use of mycophenolate mofetil, cyclophosphamide and methotrexate was significantly reduced. The above differences were statistically significant (all P < 0.05).  Conclusion  Compared with ASLE, patients with LSLE have fewer typical SLE clinical manifestations, a long time from onset to diagnosis, relatively mild disease, low dose of glucocorticoids and fewer types of immunosuppressants.

     

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