Research progress of alternative splicing in autoimmune diseases

CHU Yiran; XU Shengqian

doi:10.16766/j.cnki.issn.1674-4152.003086

Volume 21 Issue 7

Jul. 2023

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CHU Yiran, XU Shengqian. Research progress of alternative splicing in autoimmune diseases[J]. Chinese Journal of General Practice, 2023, 21(7): 1211-1214. doi: 10.16766/j.cnki.issn.1674-4152.003086

Citation:

CHU Yiran, XU Shengqian. Research progress of alternative splicing in autoimmune diseases[J]. Chinese Journal of General Practice, 2023, 21(7): 1211-1214. doi: 10.16766/j.cnki.issn.1674-4152.003086

CHU Yiran, XU Shengqian. Research progress of alternative splicing in autoimmune diseases[J]. Chinese Journal of General Practice, 2023, 21(7): 1211-1214. doi: 10.16766/j.cnki.issn.1674-4152.003086

Citation:

CHU Yiran, XU Shengqian. Research progress of alternative splicing in autoimmune diseases[J]. Chinese Journal of General Practice, 2023, 21(7): 1211-1214. doi: 10.16766/j.cnki.issn.1674-4152.003086

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Research progress of alternative splicing in autoimmune diseases

doi: 10.16766/j.cnki.issn.1674-4152.003086

CHU Yiran
, XU Shengqian^,

Department of Rheumatology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China

Funds:

320.6750.2020-03-4

Received Date: 2022-03-06
Available Online: 2023-08-28

Abstract

Abstract

Alternative splicing (AS) is a general mechanism for regulating gene expression, and up to 95% of human genes experience AS, meaning that this post-transcriptional regulatory mechanism is critical for almost all cellular processes. The general function of AS is to increase the diversity of mRNA expressed from the genome. AS alters the protein encoded by mRNA, which can have profound functional effects. AS is also observed in gene products of metazoan immune systems that have evolved to effectively recognize pathogens and distinguish between "self" and "non-self", possibly thanks to the diversity and flexibility that AS provides. Human immune response is a complex process that responds to many exogenous antigens, prevents microbial infections, and monitors endogenous components of tumors and autoimmune diseases, and requires a large number of molecules to support functional complex immune activities. Alternative splicing of pre-mRNA plays an important role in immune cell development and regulation of immune activity by generating multiple transcription subtypes to supplement the function of limited genes associated with immune response. In addition, multiple factors have been identified to be involved in the control of alternative splicing, where abnormal splicing of RNA can lead to infections, immune diseases, abnormalities in immune activity, and tumors. In this review, we focus on the regulation of AS in immune system cells, their impact on immunobiology and AS and autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. We summarize some of the recent findings that AS is associated with autoimmune diseases, and try to find common patterns of splicing regulation that may advance our understanding of autoimmune diseases and open up new therapeutic approaches.
- Autoimmune diseases,
- Alternative splicing,
- Alternative splicing,
- Gene expression

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References(37)

References

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Research progress of alternative splicing in autoimmune diseases

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