Volume 21 Issue 5
May  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(5): 784-787
FENG Yuting, SHENG Shaoqin, YU Xiao. Analysis of lipid and lipoprotein levels of women in different reproductive aging stages[J]. Chinese Journal of General Practice, 2023, 21(5): 784-787. doi: 10.16766/j.cnki.issn.1674-4152.002983
Citation: FENG Yuting, SHENG Shaoqin, YU Xiao. Analysis of lipid and lipoprotein levels of women in different reproductive aging stages[J]. Chinese Journal of General Practice, 2023, 21(5): 784-787. doi: 10.16766/j.cnki.issn.1674-4152.002983
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Analysis of lipid and lipoprotein levels of women in different reproductive aging stages

doi: 10.16766/j.cnki.issn.1674-4152.002983
  • 1.

    Nutriology Department, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, China

Funds:

 2022ZB155

  • Received Date: 2022-03-10
    Abstract
  •   Objective  To analyse the lipid and lipoprotein levels of women in different reproductive aging stages and different age groups.  Methods  A total of 944 female patients aged from 40 to 60 years who were hospitalized in the Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine from January to December 2020 were selected and divided into three groups according to STRAW+10: reproductive period (n=352), perimenopausal period (n=127) and postmenopausal period (n=465). BMI, serum total cholesterol (TC), serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein A1 (Apo A1), apolipoprotein B (Apo B), apolipoprotein E (Apo E), and lipoprotein [Lp(a)] were compared in each group.  Results  (1) The TC level significantly differed among reproductive, perimenopausal and postmenopausal periods [(4.65±0.98) mmol/L vs. (4.75±1.02) mmol/L vs. (4.99±1.03) mmol/L (P < 0.05)]. The levels of TG, LDL-C and non-HDL-C were also significantly different (all P < 0.05). (2) The TC, LDL-C and non-HDL-C levels were significantly different among the three groups with ages ranging from 50 to 60 years (all P < 0.05). (3) The levels of Apo B and Apo E were significantly different among the three groups (all P < 0.05). (4) The abnormal incidence rates of TC and LDL-C were significantly higher in the postmenopausal period than in the reproductive period or perimenopausal period (all P < 0.017).  Conclusion  Some blood lipids and lipoproteins of women in different reproductive aging states have changed, especially in women aged more than 50 years.

     

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    • References(21)
  • [1]
    KO S H, KIM H S. Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women[J]. Nutrients, 2020, 12(1): 202. doi: 10.3390/nu12010202
    [2]
    中华医学会妇产科学分会绝经学组. 绝经管理与绝经激素治疗中国指南(2018)[J]. 中华妇产科杂志, 2018, 53(11): 729-739. doi: 10.3760/cma.j.issn.0529-567x.2018.11.001

    Menopause Group, Chinese Society of Obstetrics and Gynecology. Chinese Guidelines for Menopause Management and Hormone Therapy (2018)[J]. Chinese Journal of Obstetrics and Gynecology, 2018, 53(11): 729-739. doi: 10.3760/cma.j.issn.0529-567x.2018.11.001
    [3]
    中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 血脂异常基层诊疗指南(2019年)[J]. 中华全科医师杂志, 2019, 18(5): 406-416.

    Chinese Medical Association, Chinese Medical Journals Publishing House, Chinese Society of General Pradice, et al. Guidelines for Primary Diagnosis and Treatment of Dyslipidemia (2019)[J]. Chinese JOurnal of General Practitioners, 2019, 18(5): 406-416.
    [4]
    刘璐, 姜雨佑, 李书书. 性激素及其受体在肝脏脂类代谢中的作用机制研究进展[J]. 中华内分泌代谢杂志, 2020, 36(3): 267-272.

    LIU L, JIANG Y Y, LI S S. Research progress on the mechanism of sex hormones and their receptors in liver lipid metabolism[J]. Chinese Journal of Endocrinology and Metabolism, 2020, 36(3): 267-272.
    [5]
    PINKAS J, BOJAR I, GUJSKI M, et al. Serum lipid, vitamin D levels, and obesity in perimenopausal and postmenopausal women in non-manual employment[J]. Med Sci Monit, 2017, 23: 5018-5026. doi: 10.12659/MSM.906895
    [6]
    王宁, 郑延坤, 秦明照. 绝经后女性促卵泡激素水平与血脂指标的关系[J]. 吉林大学学报(医学版), 2020, 46(1): 144-148. https://www.cnki.com.cn/Article/CJFDTOTAL-BQEB202001027.htm

    WANG N, ZHENG Y K, QIN M Z. Relationships between follicle-stimulating hormone level and lipid profiles in post-menopausal women[J]. Journal of Jilin University (Medical Edition), 2020, 46(1): 144-148. https://www.cnki.com.cn/Article/CJFDTOTAL-BQEB202001027.htm
    [7]
    SERVIENTE C, TUOMAINEN T P, VIRTANEN J, et al. Follicle-stimulating hormone is associated with lipids in postmenopausal women[J]. Menopause, 2019, 26(5): 540-545. doi: 10.1097/GME.0000000000001273
    [8]
    马依彤. 动脉粥样硬化患者甘油三酯升高的管理中国专家共识要点与解读[J]. 中国循环杂志, 2019, 34(z1): 66-68. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH2019S1015.htm

    MA Y T. Chinese expert consensus and interpretation on the management of elevated triglycerides in patients with atherosclerosis[J]. Chinese Circulation Journal, 2019, 34(z1): 66-68. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH2019S1015.htm
    [9]
    戴贤勇, 陈玮, 王燕, 等. 血清同型半胱氨酸和血脂水平与进展性缺血性脑卒中患者神经功能相关性分析[J]. 中国基层医药, 2021, 28(10): 1521-1524. https://www.cnki.com.cn/Article/CJFDTOTAL-YYLC201906009.htm

    DAI X Y, CHEN W, WANG Y, et al. Correlation of homocysteine and blood lipid levels with neurological function in patients with progressive ischemic stroke[J]. Chinese Journal of Primary Medicine and Pharmacy, 2021, 28(10): 1521-1524. https://www.cnki.com.cn/Article/CJFDTOTAL-YYLC201906009.htm
    [10]
    苑小星. 脂质代谢异常与恶性肿瘤相关性研究进展[J]. 中国基层医药, 2020, 27(18): 2300-2304.

    YUAN X X. Research progress on the relationship between dyslipidemia and malignant tumor[J]. Chinese Journal of Primary Medicine and Pharmacy, 2020, 27(18): 2300-2304.
    [11]
    ZHANG L, LIU Q, ZENG X, et al. Association of dyslipidaemia with osteoporosis in postmenopausal women[J]. J Int Med Res, 2021, 49(3): 300060521999555. DOI: 10.1177/0300060521999555.
    [12]
    罗文平, 李小玉, 骆嵩, 等. 血清脂蛋白(a)水平与青年缺血性卒中CISS分型及严重程度的关系[J]. 中华全科医学, 2021, 19(7): 1091-1094, 1102. doi: 10.16766/j.cnki.issn.1674-4152.001992

    LUO W P, LI X Y, LUO S, et al. Relationship between serum lipoprotein(a)level and CISS classification and severity of ischemic stroke in youth[J]. Chinese Journal of General Practice, 2021, 19(7): 1091-1094, 1102. doi: 10.16766/j.cnki.issn.1674-4152.001992
    [13]
    陈瑶琳, 王尹曼, 方达伟, 等. 脂蛋白(a)与冠状动脉病变严重程度的关系及对不良心血管事件的影响[J]. 中国临床医学, 2021, 28(1): 70-74. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX202101013.htm

    CHEN Y L, WANG Y M, FANG D W, et al. Relationship between lipoprotein(a)and the severity of coronary artery disease and its influence on major adverse cardiovascular events[J]. Chinese Journal Of Clinical Medicine, 2021, 28(1): 70-74. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX202101013.htm
    [14]
    侯云, 张秀兰. 血清脂蛋白a与急性心肌梗死的相关性分析[J]. 中国医药, 2021, 16(11): 1606-1609. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYG202111002.htm

    HOU Y, ZHANG X L. Correlation analysis between serum lipoprotein a and acute myocardial infarction[J]. Chinese medicine, 2021, 16(11): 1606-1609. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYG202111002.htm
    [15]
    MACH F, BAIGENT C, CATAPANO A L, et al. 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk[J]. Eur Heart J, 2020, 41(1): 111-188.
    [16]
    LI C, CHEN J, WEI S, et al. Particles and corrected particles of LDL and non-HDL are stronger predicters of coronary lesion in postmenopausal women[J]. BMC Cardiovasc Disord, 2021, 21(1): 369.
    [17]
    IVERT T, HAMMAR N, TALBǍCK M, et al. Elevated apolipoprotein B/A-1 ratio is associated with an increased risk of aortic stenosis: experience from the AMORIS cohort[J]. Heart Lung Circ, 2021, 30(7): 1050-1057.
    [18]
    MARAIS A D. Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease[J]. Pathology, 2019, 51(2): 165-176.
    [19]
    李晓轩, 边云飞, 邱龄, 等. 载脂蛋白E基因多态性与女性冠心病相关性的Meta分析[J]. 中国动脉硬化杂志, 2019, 27(10): 893-898. https://www.cnki.com.cn/Article/CJFDTOTAL-KDYZ201910012.htm

    LI X X, BIAN Y F, QIU L, et al. Meta analysis of the correlation between apolipoprotein E gene polymorphism and coronary heart disease in women[J]. Chinese Journal of Arteriosclerosis, 2019, 27(10): 893-898. https://www.cnki.com.cn/Article/CJFDTOTAL-KDYZ201910012.htm
    [20]
    黄柳, 戴昕妤, 田雪, 等. ApoE基因型与颈动脉粥样硬化及脑梗死的相关性研究[J]. 中华全科医学, 2021, 19(8): 1287-1291. doi: 10.16766/j.cnki.issn.1674-4152.002042

    HUANG L, DAI X S, TIAN X, et al. Correlation between ApoE genotype and carotid atherosclerosis and cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(8): 1287-1291. doi: 10.16766/j.cnki.issn.1674-4152.002042
    [21]
    SERRANO-POZO A, DAS S, HYMAN B T. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches[J]. Lancet Neurol, 2021, 20(1): 68-80.
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