Volume 21 Issue 3
Mar.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(3): 477-480
LI Dong, WU Qiang, ZHANG Hongliang, BAI Feng. Atrial fibrillation and erectile dysfunction[J]. Chinese Journal of General Practice, 2023, 21(3): 477-480. doi: 10.16766/j.cnki.issn.1674-4152.002911
Citation: LI Dong, WU Qiang, ZHANG Hongliang, BAI Feng. Atrial fibrillation and erectile dysfunction[J]. Chinese Journal of General Practice, 2023, 21(3): 477-480. doi: 10.16766/j.cnki.issn.1674-4152.002911
shu

Atrial fibrillation and erectile dysfunction

doi: 10.16766/j.cnki.issn.1674-4152.002911

  • Department of Cardiology, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China

Funds:

 20JR5RA343

  • Received Date: 2022-05-06
    Available Online: 2023-04-19
    Abstract
  • Despite advances in health care technology that have reduced mortality rates caused by cardiovascular disease over the years, cardiovascular events continue to be a significant cause of shortened life expectancy in the global population, with men developing the disease at an earlier age than women. Identifying and reducing the risk factors of cardiovascular diseases plays an important role in improving the prognosis of cardiovascular diseases. A good sexual life is also an important part of health. Sexual dysfunction, particularly erectile dysfunction in men, has a high prevalence in the population, which increases progressively with age. Atrial fibrillation (AF) and erectile dysfunction are often coexisting, and they share many similar risk factors, as well as pathophysiological pathways. Erectile dysfunction, as an independent risk factor for cardiovascular diseases, is also important in predicting the occurrence and progression of AF. In addition, erectile dysfunction is an important cause of discontinuation or poor compliance with treatment for cardiovascular diseases. Screening and diagnosis of erectile dysfunction may provide a simple and practical tool for assessing the prognosis of AF. Some therapies for erectile dysfunction have improved vascular endothelial function while improving atrial myocardial blood supply and reducing inflammation levels, with testosterone acting on atrial myocardial membrane ion channels to reduce abnormal spontaneous triggering potentials in atrial myocardium, thereby reducing the risk of AF. The relationship between erectile dysfunction and AF has been increasingly studied, and endothelial dysfunction, inflammation and testosterone deficiency play an important role in the pathogenesis of both conditions, but the exact mechanisms remain unclear. This article provides a review of the effects of erectile dysfunction and related treatments on AF.

     

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  • [1]
    ROTH G A, MENSAH G A, JOHNSON C O, et al. Global burden of cardiovascular diseases and risk factors, 1990-2019: update From the GBD 2019 Study[J]. J Am Coll Cardiol, 2020, 76(25): 2982-3021. doi: 10.1016/j.jacc.2020.11.010
    [2]
    SALONIA A, BETTOCCHI C, BOERI L, et al. European association of urology guidelines on sexual and reproductive health-2021 update: male sexual dysfunction[J]. Eur Urol, 2021, 80(3): 333-357. doi: 10.1016/j.eururo.2021.06.007
    [3]
    STEINFELDT J, BUERGEL T, LOOCK L, et al. Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort[J]. Lancet Digit Health, 2022, 4(2): e84-e94. doi: 10.1016/S2589-7500(21)00249-1
    [4]
    TANAKA Y, BUNDY J D, ALLEN N B, et al. Association of erectile dysfunction with incident atrial fibrillation: the multi-ethnic study of atherosclerosis (MESA)[J]. Am J Med, 2020, 133(5): 613-620.e1. DOI: 10.1016/j.amjmed.2019.08.052.
    [5]
    GOLDSTEIN I, GOREN A, LI V W, et al. Epidemiology update of erectile dysfunction in eight countries with high burden[J]. Sex Med Rev, 2020, 8(1): 48-58. doi: 10.1016/j.sxmr.2019.06.008
    [6]
    CHOKESUWATTANASKUL R, THONGPRAYOON C, PACHARIYANON P, et al. Erectile dysfunction and atrial fibrillation: a systematic review and meta-analysis[J]. Int J Urol, 2018, 25(8): 752-757. doi: 10.1111/iju.13725
    [7]
    ÖNCEL C R, AKKOÇ A. P wave dispersion in patients with erectile dysfunction[J]. Interv Med Appl Sci, 2019, 11(2): 101-105.
    [8]
    ALTUNKOL A, TOPUZ A N, GENC O, et al. Atrial electromechanical duration prolongs in patients with erectile dysfunction[J]. Aging Male, 2020, 23(2): 154-160. doi: 10.1080/13685538.2019.1650336
    [9]
    LEHRER P, KAUR K, SHARMA A, et al. Heart rate variability biofeedback improves emotional and physical health and performance: a systematic review and meta analysis[J]. Appl Psychophysiol Biofeedback, 2020, 45(3): 109-129. doi: 10.1007/s10484-020-09466-z
    [10]
    PRASITLUMKUM N, KEWCHAROEN J, KANITSORAPHAN C, et al. Baseline atrial fibrillation is a risk factor for erectile dysfunction: systemic review and meta-analysis[J]. Arab J Urol, 2019, 17(2): 98-105. doi: 10.1080/2090598X.2019.1601001
    [11]
    ASSAR M E, ANGULO J, GARCÍA-ROJO E, et al. Early manifestation of aging-related vascular dysfunction in human penile vasculature-A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease[J]. Geroscience, 2022, 44(1): 485-501. doi: 10.1007/s11357-021-00507-x
    [12]
    CORBAN M T, GODO S, BURCZAK D R, et al. Coronary Endothelial dysfunction is associated with increased risk of incident atrial fibrillation[J]. J Am Heart Assoc, 2020, 9(8): e014850. DOI: 10.1161/JAHA.119.014850.
    [13]
    KOMATSU T, KUNUGITA F, OZAWA M, et al. Relationship between impairment of the vascular endothelial function and the CHA2DS2-VASc Score in patients with sinus rhythm and non-valvular atrial fibrillation[J]. Intern Med, 2018, 57(15): 2131-2139. doi: 10.2169/internalmedicine.9831-17
    [14]
    KANAZAWA H, KAIKITA K, ITO M, et al. Improvement of vascular endothelial function reflects nonrecurrence after catheter ablation for atrial fibrillation[J]. J Am Heart Assoc, 2021, 10(17): e021551. DOI: 10.1161/JAHA.121.021551.
    [15]
    TYRRELL D J, BLIN M G, SONG J, et al. Age-associated mitochondrial dysfunction accelerates atherogenesis[J]. Circ Res, 2020, 126(3): 298-314. doi: 10.1161/CIRCRESAHA.119.315644
    [16]
    ZOLOTOVSKAYA I A, DAVYDKIN I L. Endothelial dysfunction a significant marker of adverse clinical outcome in patients with atrial fibrillation after cardioembolic stroke[J]. Ter Arkh, 2019, 91(1): 53-59.
    [17]
    ZELLER T, SCHNABEL R B, APPELBAUM S, et al. Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women-results from the FINRISK study[J]. Eur J Prev Cardiol, 2018, 25(11): 1133-1139. doi: 10.1177/2047487318778346
    [18]
    O'NEAL W T, NAZARIAN S, ALONSO A, et al. Sex hormones and the risk of atrial fibrillation: the multi-ethnic study of atherosclerosis (MESA)[J]. Endocrine, 2017, 58(1): 91-96. doi: 10.1007/s12020-017-1385-3
    [19]
    BERGER D, FOLSOM A R, SCHREINER P J, et al. Plasma total testosterone and risk of incident atrial fibrillation: the atherosclerosis risk in communities (ARIC) study[J]. Maturitas, 2019, 125: 5-10. doi: 10.1016/j.maturitas.2019.03.015
    [20]
    TERENTES-PRINTZIOS D, IOAKEIMIDIS N, ROKKAS K, et al. Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs[J]. Nat Rev Cardiol, 2022, 19(1): 59-74. doi: 10.1038/s41569-021-00593-6
    [21]
    NOFI C, ZHANG K, TANG Y D, et al. Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure model[J]. Heart Rhythm O2, 2020, 1(2): 126-135. doi: 10.1016/j.hroo.2020.03.004
    [22]
    TAKAFUJI M, KITAGAWA K, NAKAMURA S, et al. Hyperemic myocardial blood flow in patients with atrial fibrillation before and after catheter ablation: a dynamic stress CT perfusion study[J]. Physiol Rep, 2021, 9(22): e15123. DOI: 10.14814/phy2.15123.
    [23]
    PRIVIERO F, CALMASINI F, DELA JUSTINA V, et al. Macrophage-specific toll like receptor 9 (TLR9) causes corpus cavernosum dysfunction in mice fed a high fat diet[J]. J Sex Med, 2021, 18(4): 723-731. doi: 10.1016/j.jsxm.2021.01.180
    [24]
    王冰, 徐依多, 邵山, 等. 18F-FDG PET/CT测量的左心房心外膜脂肪炎症活性与心房颤动的相关性[J]. 中华心血管病杂志, 2021, 49(12): 1213-1219. doi: 10.3760/cma.j.cn112148-20211026-00913

    WANG B, XYU Y D, SHAO S, et al. Association between inflammation activity of left atrial epicardial adipose tissue measured by 18F?FDG PET/CT and atrial fibrillation[J]. Chinese Journal of Cardiology, 2021, 49(12): 1213-1219. doi: 10.3760/cma.j.cn112148-20211026-00913
    [25]
    ZANOLI L, BRIET M, EMPANA J P, et al. Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society[J]. J Hypertens, 2020, 38(9): 1682-1698. doi: 10.1097/HJH.0000000000002508
    [26]
    FURMANIK M, VAN GORP R, WHITEHEAD M, et al. Endoplasmic reticulum stress mediates vascular smooth muscle cell calcification via increased release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles[J]. Arterioscler Thromb Vasc Biol, 2021, 41(2): 898-914. doi: 10.1161/ATVBAHA.120.315506
    [27]
    NALLIAH C J, BELL J R, RAAIJMAKERS A J A, et al. Epicardial Adipose tissue accumulation confers atrial conduction abnormality[J]. J Am Coll Cardiol, 2020, 76(10): 1197-1211. doi: 10.1016/j.jacc.2020.07.017
    [28]
    CHEN S K, BARBHAIYA M, SOLOMON D H, et al. Atrial fibrillation/flutter hospitalizations among US medicaid recipients with and without systemic lupus erythematosus[J]. J Rheumatol, 2020, 47(9): 1359-1365. doi: 10.3899/jrheum.190502
    [29]
    KILBY E L, KELLY D M, JONES T H. Testosterone stimulates cholesterol clearance from human macrophages by activating LXRα[J]. Life Sci, 2021, 269: 119040. DOI: 10.1016/j.lfs.2021.119040.
    [30]
    SAAD F, CALIBER M, DOROS G, et al. Long-term treatment with testosterone undecanoate injections in men with hypogonadism alleviates erectile dysfunction and reduces risk of major adverse cardiovascular events, prostate cancer, and mortality[J]. Aging Male, 2020, 23(1): 81-92. doi: 10.1080/13685538.2019.1575354
    [31]
    ZHANG Y, WANG H M, WANG Y Z, et al. Increment of late sodium currents in the left atrial myocytes and its potential contribution to increased susceptibility of atrial fibrillation in castrated male mice[J]. Heart Rhythm, 2017, 14(7): 1073-1080. doi: 10.1016/j.hrthm.2017.01.046
    [32]
    CESARINI V, GUIDA E, CAMPOLO F, et al. Type 5 phosphodiesterase (PDE5) and the vascular tree: from embryogenesis to aging and disease[J]. Mech Ageing Dev, 2020, 190: 111311. DOI: 10.1016/j.mad.2020.111311.
    [33]
    NIO Y, OOKAWARA M, YAMASAKI M, et al. Ameliorative effect of phosphodiesterase 4 and 5 inhibitors in deoxycorticosterone acetate-salt hypertensive uni-nephrectomized KKAy mice[J]. FASEB J, 2020, 34(11): 14997-15014. doi: 10.1096/fj.202001084R
    [34]
    BRUNT V E, GIOSCIA-RYAN R A, CASSO A G, et al. Trimethylamine-N-Oxide promotes age-related vascular oxidative stress and endothelial dysfunction in mice and healthy humans[J]. Hypertension, 2020, 76(1): 101-112. doi: 10.1161/HYPERTENSIONAHA.120.14759
    [35]
    DIAS A T, LEAL M A S, ZANARDO T C, et al. Beneficial morphofunctional changes promoted by sildenafil in resistance vessels in the angiotensin Ⅱ-induced hypertension model[J]. Curr Pharm Biotechnol, 2018, 19(6): 483-494. doi: 10.2174/1389201019666180625094704
    [36]
    KOKA S, XI L, KUKREJA R C. Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide[J]. Mol Cell Biochem, 2020, 468(1-2): 47-58. doi: 10.1007/s11010-020-03710-0
    [37]
    ANDERSSON D P, LANDUCCI L, LAGERROS Y T, et al. Association of Phosphodiesterase-5 inhibitors versus alprostadil with survival in men with coronary artery disease[J]. J Am Coll Cardiol, 2021, 77(12): 1535-1550. doi: 10.1016/j.jacc.2021.01.045
    [38]
    王庆, 樊千, 周正国, 等. 东升扶桑饮对痰湿型勃起功能障碍患者内皮功能保护作用的临床研究[J]. 中华全科医学, 2019, 17(5): 841-843, 861. doi: 10.16766/j.cnki.issn.1674-4152.000806

    WANG Q, FAN Q, ZHOU Z G, et al. Protective effect of Dongsheng Fusang decoction on endothelial function in phlegm-dampness type erectile dysfunction patient[J]. Chinese Journal of General Practice, 2019, 17(5): 841-843, 861. doi: 10.16766/j.cnki.issn.1674-4152.000806
    [39]
    GIANNATTASIO S, CORINALDESI C, COLLETTI M, et al. The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence[J]. J Endocrinol Invest, 2019, 42(6): 715-725. doi: 10.1007/s40618-018-0977-y
    [40]
    CHUNG C C, LIN Y K, KAO Y H, et al. Physiological testosterone attenuates profibrotic activities of rat cardiac fibroblasts through modulation of nitric oxide and calcium homeostasis[J]. Endocr J, 2021, 68(3): 307-315. doi: 10.1507/endocrj.EJ20-0344
    [41]
    LAM Y T, HSU C J, SIMPSON P J L, et al. Androgens stimulate EPC-mediated neovascularization and are associated with increased coronary collateralization[J]. Endocrinology, 2020, 161(5): bqaa043. DOI: 10.1210/endocr/bqaao43.
    [42]
    WITTERT G, BRACKEN K, ROBLEDO K P, et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial[J]. Lancet Diabetes Endocrinol, 2021, 9(1): 32-45. doi: 10.1016/S2213-8587(20)30367-3
    [43]
    LUO S, AU YEUNG S L, ZHAO J V, et al. Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank[J]. BMJ, 2019, 364: 1476.
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