Clinical progress of postoperative analgesia in neonates

ZHANG Xian; YAN Fu-xia; CHEN Ling-yu; PAN Shou-dong

doi:10.16766/j.cnki.issn.1674-4152.002867

Volume 21 Issue 2

Feb. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(2): 292-297

ZHANG Xian, YAN Fu-xia, CHEN Ling-yu, PAN Shou-dong. Clinical progress of postoperative analgesia in neonates[J]. Chinese Journal of General Practice, 2023, 21(2): 292-297. doi: 10.16766/j.cnki.issn.1674-4152.002867

Citation:

ZHANG Xian, YAN Fu-xia, CHEN Ling-yu, PAN Shou-dong. Clinical progress of postoperative analgesia in neonates[J]. Chinese Journal of General Practice, 2023, 21(2): 292-297. doi: 10.16766/j.cnki.issn.1674-4152.002867

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Clinical progress of postoperative analgesia in neonates

doi: 10.16766/j.cnki.issn.1674-4152.002867

1.
Capital Pediatric Institute/Peking Union Medical College, Beijing 100020, China

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Z181100001718096

PY-2020-08

Received Date: 2022-02-23
Available Online: 2023-04-20

Abstract

Abstract

Given the developmental physiological and pharmacokinetic characteristics of neonates, the postoperative analgesia for this population remains limited to a certain extent. Neonates, particularly preterm infants, are only provided with minimal or no anaesthesia and analgesia. With the in-depth study of physiology, the importance of neonatal analgesia has been paid considerable attention, and postoperative analgesia has begun to develop towards on-demand multi-mode analgesia. Postoperative analgesia for neonates in clinic has various ways, but no unified guide is developed for the drugs and measures of neonatal postoperative analgesia, and clinicians still have concerns about the implementation of neonatal postoperative analgesia. Therefore, this paper summarised the existing methods of postoperative analgesia for neonates. The data are primarily obtained from published clinical studies and case reports, and the specific dosage, analgesic effect, adverse reactions and precautions of various drugs used in postoperative analgesia were counted; thus, clinicians can select appropriate analgesic methods based on the specific situation of children. Based on the classification of analgesic drugs, including opioids (morphine, fentanyl, sufentanil and tramadol), non-opioid drugs (acetaminophen, ketorolac and pyrinidamine), local anaesthetics (bupivacaine, ropivacaine, chloroprocaine and lidocaine) and mixed local anaesthetics EMLA, the different ways and means of administration of the same drug were also summarised and analysed. Non-drug analgesic methods also include high-sugar solution, non-nutritive sucking, posture change and so on. The particularity of neonates increases the difficulty and risk of various operations and effect evaluation. Various analgesic methods still need to be verified by a large number of clinical studies.
- Neonate,
- Postoperative analgesia,
- Adverse reaction

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References(50)

References

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Clinical progress of postoperative analgesia in neonates

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Clinical progress of postoperative analgesia in neonates

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