Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy

ZHANG Su-yuan; LI Wen-wen; ZHU Ya-qi; LI Xiao-quan

doi:10.16766/j.cnki.issn.1674-4152.002866

Volume 21 Issue 2

Feb. 2023

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Chinese Journal of General Practice > 2023 > 21(2): 288-291

ZHANG Su-yuan, LI Wen-wen, ZHU Ya-qi, LI Xiao-quan. Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy[J]. Chinese Journal of General Practice, 2023, 21(2): 288-291. doi: 10.16766/j.cnki.issn.1674-4152.002866

Citation:

ZHANG Su-yuan, LI Wen-wen, ZHU Ya-qi, LI Xiao-quan. Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy[J]. Chinese Journal of General Practice, 2023, 21(2): 288-291. doi: 10.16766/j.cnki.issn.1674-4152.002866

Citation:

PDF( 402 KB)

Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy

doi: 10.16766/j.cnki.issn.1674-4152.002866

1.
Department of Clinical Laboratory, Rongjun Hospital of Henan Province, Xinxiang, Henan 453000, China

Funds:

LHGJ20190529

Received Date: 2022-02-18
Available Online: 2023-04-20

Abstract

Abstract

Objective The clinical data of patients with liver cirrhosis-related hepatic encephalopathy (HE) were collected, and the correlation among serum interleukin-6 (IL-6), interleukin-18 (IL-18) and blood ammonia levels in patients with HE was analysed retrospectively. Methods A total of 95 patients with liver cirrhosis were selected in Rongjun Hospital of Henan province from June 2019 to January 2021. Among them, 41 patients with simple liver cirrhosis were set as non-HE group, and 54 patients with liver cirrhosis and HE were set as HE group. Another 50 healthy persons from our hospital were selected as the health group in the same period. The levels of serum ammonia, IL-6 and IL-18 were compared among the three groups. Differences in the clinical data between HE and non-HE groups were compared, and the risk factors of HE were determined by logistic regression analysis. Pearson correlation analysis was used to evaluate the correlation among serum levels of ammonia, IL-6 and IL-18. Results The levels of serum IL-6, IL-18 and blood ammonia in the non-HE and HE groups were higher than those in the healthy group (P < 0.05). The levels of serum IL-6, IL-18 and blood ammonia in the HE group were higher than those in non-HE group (P < 0.05). Logistic regression analysis showed that high serum levels of IL-6, IL-18, total bilirubin (TBIL) and long prothrombin time (PT) were risk factors for cirrhosis-related HE (P < 0.05). Pearson correlation analysis showed that serum IL-6 was positively correlated with serum ammonia level (r=0.690, P < 0.001, 95% CI: 0.518-0.808), and IL-18 was positively correlated with blood ammonia level (r=0.667, P < 0.001, 95% CI: 0.487-0.793). Conclusion High serum levels of IL-6, IL-18, TBIL and long PT are risk factors for hepatocirrhosis-related HE, and serum IL-6 and IL-18 levels are positively correlated with the average level of blood ammonia.
- Liver cirrhosis,
- Hepatic encephalopathy,
- Interleukin 6,
- Interleukin 18,
- Blood ammonia

FullText(HTML)

References(19)

References

[1]	ZHUGE W S, ZHUGE Q C, WANG W K, et al. Hydrogen sulphide ameliorates dopamine-induced astrocytic inflammation and neurodegeneration in minimal hepatic encephalopathy[J]. J Cell Mol Med, 2020, 24(23): 13634-13647. doi: 10.1111/jcmm.15728
[2]	关珂, 杨婷婷, 杨阳, 等. 1例肝性脑病营养支持实施的病例报道[J]. 中华全科医学, 2021, 19(2): 336-338. doi: 10.16766/j.cnki.issn.1674-4152.001803 GUAN K, YANG T T, YANG Y, et al. A case report of nutritional support for hepatic encephalopathy[J]. Chinese Journal of General Practice, 2021, 19(2): 336-338. doi: 10.16766/j.cnki.issn.1674-4152.001803
[3]	MANZHALII E, VIRCHENKO O, FALALYEYEVA T, et al. Hepatic encephalopathy aggravated by systemic inflammation[J]. Dig Dis, 2019, 37(6): 509-517. doi: 10.1159/000500717
[4]	贾继东, 李兰娟. 慢性乙型肝炎防治指南(2010年版)[J]. 实用肝脏病杂志, 2011, 16(1): 2-16. https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201603038.htm JIA J D, LI L J. Guidelines for Chronic Hepatitis B (2010 Edition)[J]. Journal of Clinical Hepatology, 2011, 16(1): 2-16. https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201603038.htm
[5]	中华医学会消化病学分会, 中华医学会肝病学分会. 中国肝性脑病诊治共识意见(2013年, 重庆)[J]. 中华消化杂志, 2014, 33(2): 81-93. https://cdmd.cnki.com.cn/Article/CDMD-10611-1014044856.htm Chinese Society of Gastroenterology, Hepatology Branch of Chinese Medical Association. Consensus on Diagnosis and Treatment of hepatic encephalopathy in China (Chongqing, 2013)[J]. Chinese Journal of Digestion, 2014, 33(2): 81-93. https://cdmd.cnki.com.cn/Article/CDMD-10611-1014044856.htm
[6]	BAI Z H, BERNARDI M, YOSHIDA E M, et al. Albumin infusion may decrease the incidence and severity of overt hepatic encephalopathy in liver cirrhosis[J]. Aging (Albany NY), 2019, 11(19): 8502-8525.
[7]	LUO S H, CHU J G, HUANG H, et al. Targeted puncture of left branch of intrahepatic portal vein in transjugular intrahepatic portosystemic shunt to reduce hepatic encephalopathy[J]. World J Gastroenterol, 2019, 25(9): 1088-1099. doi: 10.3748/wjg.v25.i9.1088
[8]	AMPUERO J, GIL A, VILORIA M D M, et al. Oral glutamine challenge is a marker of altered ammonia metabolism and predicts the risk of hepatic encephalopathy[J]. Liver Int, 2020, 40(4): 921-930. doi: 10.1111/liv.14297
[9]	LABENZ C, TOENGES G, HUBER Y, et al. Raised serum Interleukin-6 identifies patients with liver cirrhosis at high risk for overt hepatic encephalopathy[J]. Aliment Pharmacol Ther, 2019, 50(10): 1112-1119. doi: 10.1111/apt.15515
[10]	FURUTAMA D, MATSUDA S, YAMAWAKI Y, et al. IL-6 Induced by periodontal inflammation causes neuroinflammation and disrupts the blood-brain barrier[J]. Brain Sci, 2020, 10(10): 679. doi: 10.3390/brainsci10100679
[11]	CHEN C, LIU Y H, CHENG S B, et al. The hepatoprotective effects of XCHD and MgIG against methotrexate-induced liver injury and inflammation in rats through suppressing the activation of AIM2 inflammasomes[J]. Pathol Res Pract, 2020, 216(4): 152875. doi: 10.1016/j.prp.2020.152875
[12]	YAP J K Y, PICKARD B S, CHAN E W L, et al. The role of neuronal NLRP1 inflammasome in Alzheimer ' s disease: bringing neurons into the neuroinflammation game[J]. Mol Neurobiol, 2019, 56(11): 7741-7753. doi: 10.1007/s12035-019-1638-7
[13]	KONG E L, ZHANG J M, AN N, et al. Spironolactone rescues renal dysfunction in obstructive jaundice rats by upregulating ACE2 expression[J]. J Cell Commun Signal, 2018, 13(1): 17-26.
[14]	李丹, 张才江. 溶血磷脂酸受体, 自分泌运动因子在肝硬化肝性脑病患者中的表达及意义[J]. 肝脏, 2020, 25(3): 313-316. doi: 10.3969/j.issn.1008-1704.2020.03.027 LI D, ZHANG C J. Expression and significance of lysophosphatidic acid receptor and autocrine motility factor in patients with cirrhosis and hepatic encephalopathy[J]. Chinese Hepatology, 2020, 25(3): 313-316. doi: 10.3969/j.issn.1008-1704.2020.03.027
[15]	SEPEHRINEZHAD A, ZARIFKAR A, NAMVAR G, et al. Astrocyte swelling in hepatic encephalopathy: molecular perspective of cytotoxic edema[J]. Metab Brain Dis, 2020, 35(4): 559-578. doi: 10.1007/s11011-020-00549-8
[16]	ANAMIKA F, TRIGUN S K. Sirtuin-3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity[J]. J Biochem Mol Toxicol, 2021, 35(5): e22735. DOI: 10.1002/jbt.22735.
[17]	CHENG L, WANG X Y, MA X N, et al. Effect of dihydromyricetin on hepatic encephalopathy associated with acute hepatic failure in mice[J]. Pharm Biol, 2021, 59(1): 557-564.
[18]	李乐辉, 吴国平, 林润. 血清Trp联合血氨检测提高急诊ICU肝性脑病早期诊断灵敏度的临床价值[J]. 肝脏, 2019, 24(4): 415-417. doi: 10.3969/j.issn.1008-1704.2019.04.022 LI L H, WU G P, LIN R. Clinical value of serum Trp combined with ammonia detection to improve the sensitivity of early diagnosis of hepatic encephalopathy in emergency ICU[J]. Chinese Hepatology, 2019, 24(4): 415-417. doi: 10.3969/j.issn.1008-1704.2019.04.022
[19]	中华医学会肝病学分会. 肝硬化肝性脑病诊疗指南[J]. 传染病信息, 2018, 31(5): 403-420. doi: 10.3969/j.issn.1007-8134.2018.05.003 Hepatology Branch of Chinese Medical Association. Guidelines on the management of hepatic encephalopathy in cirrhosis[J]. Infectious Disease Information, 2018, 31(5): 403-420. doi: 10.3969/j.issn.1007-8134.2018.05.003

Relative Articles

[1]	CHEN Xiu, YU Jian-ping, WENG Fang-fang, PAN Xiao-ben. Authorised educational diet combined with psychological intervention in viral post-hepatitis cirrhosis[J]. Chinese Journal of General Practice, 2022, 20(9): 1535-1537. doi: 10.16766/j.cnki.issn.1674-4152.002642
[2]	NIU Kai-xuan, WU Shu-lu, LIU Cheng, DENG Xi-ming. Clinical value of serum amyloid A and interleukin-6 in the diagnosis and severity evaluation of sepsis[J]. Chinese Journal of General Practice, 2022, 20(9): 1484-1487. doi: 10.16766/j.cnki.issn.1674-4152.002629
[3]	XIANG Qiong-lian, ZHU Li-juan, ZHANG Shi-hai. Clinical significance of serum amyloid protein A and interleukin-6 expression in hand, foot and mouth disease on the basis of propensity score matching[J]. Chinese Journal of General Practice, 2022, 20(4): 623-625. doi: 10.16766/j.cnki.issn.1674-4152.002415
[4]	CHEN Jin-qiang, LI Chun-da, LI Fu-qiang, LU Li-ming, FANG Bin, JIN Zhi-hua. Analysis and treatment of the risk factors for spontaneous peritonitis in patients with decompensated liver cirrhosis[J]. Chinese Journal of General Practice, 2021, 19(7): 1131-1134. doi: 10.16766/j.cnki.issn.1674-4152.002003
[5]	YAO Wei-wei, DONG Qing-hua. Observation on the clinical effect of recombinant human interleukin-11 combined with Kangfuxin liquid in the treatment of radiation-induced oral mucositis[J]. Chinese Journal of General Practice, 2021, 19(5): 775-777,785. doi: 10.16766/j.cnki.issn.1674-4152.001914
[7]	LIU Xin-xin, GAO Chun-ming, LIU Chuan-miao. Clinical characteristics of primary biliary cholangitis and RPR value in diagnosing cirrhosis[J]. Chinese Journal of General Practice, 2021, 19(3): 454-458. doi: 10.16766/j.cnki.issn.1674-4152.001834
[8]	ZHAO Xiao-hui, WANG Li-hua, SUO Li-na. Study on nursing practice of self-management model for patients with hepatitis B cirrhosis[J]. Chinese Journal of General Practice, 2020, 18(1): 146-149. doi: 10.16766/j.cnki.issn.1674-4152.001190
[9]	XU Meng. Risk factors of depression in patients with hospitalized viral hepatitis cirrhosis and the effect of psychological nursing intervention[J]. Chinese Journal of General Practice, 2017, 15(4): 715-717. doi: 10.16766/j.cnki.issn.1674-4152.2017.04.051
[10]	CHEN Yan-qiu. Clinical effect of immune therapy on 72 cases of cirrhosis complicated with infection[J]. Chinese Journal of General Practice, 2017, 15(3): 449-451. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.026
[11]	WANG Xiao-wei, SUN Jian-gang. Ultrasonographic evaluation of hepatic venous pressure gradient in patients with HBV infection and cirrhosis[J]. Chinese Journal of General Practice, 2017, 15(5): 844-846. doi: 10.16766/j.cnki.issn.1674-4152.2017.05.035
[12]	LI Yumei, ZHOU Fangfang, LUO Qun. Research progress of non-vasomotor mechanism for cirrhosis complicated by kidney injury[J]. Chinese Journal of General Practice, 2017, 15(8): 1407-1410. doi: 10.16766/j.cnki.issn.1674-4152.2017.08.039
[13]	MENG Ying, LUO Xin, ZHAO Guogen, GU Huihua, FU Xiaoqing. Changes of glycogen antigens 125 and procalcitonin in serum and ascites of patients with hepatitis B cirrhosis complicated with spontaneous bacterial peritonitis[J]. Chinese Journal of General Practice, 2017, 15(7): 1239-1241. doi: 10.16766/j.cnki.issn.1674-4152.2017.07.044
[14]	ZOU Yuqiong, JIN Weidong, LI Yasong. Serum IL-6 as the important biomarker in disease evaluation of polymyositis[J]. Chinese Journal of General Practice, 2017, 15(9): 1503-1505. doi: 10.16766/j.cnki.issn.1674-4152.2017.09.015
[15]	HUANG Guo-qing, YUAN Hua-qin, WU Jun, GAO Feng, XU Hong-en. A primary research of sound velocity tissue quantification in nonalcoholic fatty liver disease[J]. Chinese Journal of General Practice, 2016, 14(5): 826-827,857. doi: 10.16766/j.cnki.issn.1674-4152.2016.05.044
[16]	LIU Xiao-jing, LIU Rong-mei, MENG Wen, LIU Meng-jia, LI Xue-mei, YANG Yu-lan, ZHANG Yong-yong, SHANG Yu-jun. Evaluation of quality of life and nursing care for patients with hepatic cirrhosis and carcinoma[J]. Chinese Journal of General Practice, 2016, 14(9): 1592-1594. doi: 10.16766/j.cnki.issn.1674-4152.2016.09.052
[17]	ZHENG Rui, LI Miao-nan, WU Wen-ting, WANG Hong-ju. Clinical significance of plasma interleukin 33 changes in elderly acute coronary syndromes complicated with diabetic mellitus[J]. Chinese Journal of General Practice, 2016, 14(7): 1107-1110. doi: 10.16766/j.cnki.issn.1674-4152.2016.07.014
[18]	JIN Rui-fang, CHEN Ren-pin, LIN Xiu-qing, CHEN Zhou-feng, YANG Dan-hong. Effect of transjugular intrahepatic portosystemic shunt surgery on metabolism of patients with cirrhosis and portal hypertension[J]. Chinese Journal of General Practice, 2016, 14(11): 1820-1822. doi: 10.16766/j.cnki.issn.1674-4152.2016.11.009
[19]	LIN Ling, LU Bao-chun. Value of miR-224 for detection of HCC at early stage[J]. Chinese Journal of General Practice, 2016, 14(9): 1445-1448. doi: 10.16766/j.cnki.issn.1674-4152.2016.09.006
[20]	LAI Jing-lan, LIU Yu-ming, LIN Chun, PAN Chen, SUN Fang, HUANG Zu-xiong, LIN Yong, ZHOU Rui, LIN Yuan-bao. Low serum interleukin-1 receptor antagonist level leads to poor outcomes in hepatitis B-related liver failure patients[J]. Chinese Journal of General Practice, 2016, 14(5): 718-720,745. doi: 10.16766/j.cnki.issn.1674-4152.2016.05.007

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	陈雅菲，郭皓，王志民. 肝硬化食管-胃底静脉曲张破裂出血患者TIPS术后发生肝性脑病与血氨水平、肝功能和凝血功能的关系分析. 中西医结合肝病杂志. 2025(01): 36-40 .
2.	徐华栋，张玉婷. 亚临床肝性脑病患者肠道菌群和炎症因子水平变化及黄连素的干预作用. 中国医学创新. 2023(27): 141-145 .

Other cited types(0)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(4)

Get Citation

PDF

XML

Article Metrics

Article views (242) PDF downloads(4)

Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy

doi: 10.16766/j.cnki.issn.1674-4152.002866

Abstract

References

Relative Articles

Cited by

Periodical cited type(2)

Other cited types(0)

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy

doi: 10.16766/j.cnki.issn.1674-4152.002866

Abstract

References

Relative Articles

Cited by

Periodical cited type(2)

Other cited types(0)

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content