Volume 21 Issue 2
Feb.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 288-291
ZHANG Su-yuan, LI Wen-wen, ZHU Ya-qi, LI Xiao-quan. Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy[J]. Chinese Journal of General Practice, 2023, 21(2): 288-291. doi: 10.16766/j.cnki.issn.1674-4152.002866
Citation: ZHANG Su-yuan, LI Wen-wen, ZHU Ya-qi, LI Xiao-quan. Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy[J]. Chinese Journal of General Practice, 2023, 21(2): 288-291. doi: 10.16766/j.cnki.issn.1674-4152.002866
shu

Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy

doi: 10.16766/j.cnki.issn.1674-4152.002866
  • 1.

    Department of Clinical Laboratory, Rongjun Hospital of Henan Province, Xinxiang, Henan 453000, China

Funds:

 LHGJ20190529

  • Received Date: 2022-02-18
    Available Online: 2023-04-20
    Abstract
  •   Objective  The clinical data of patients with liver cirrhosis-related hepatic encephalopathy (HE) were collected, and the correlation among serum interleukin-6 (IL-6), interleukin-18 (IL-18) and blood ammonia levels in patients with HE was analysed retrospectively.  Methods  A total of 95 patients with liver cirrhosis were selected in Rongjun Hospital of Henan province from June 2019 to January 2021. Among them, 41 patients with simple liver cirrhosis were set as non-HE group, and 54 patients with liver cirrhosis and HE were set as HE group. Another 50 healthy persons from our hospital were selected as the health group in the same period. The levels of serum ammonia, IL-6 and IL-18 were compared among the three groups. Differences in the clinical data between HE and non-HE groups were compared, and the risk factors of HE were determined by logistic regression analysis. Pearson correlation analysis was used to evaluate the correlation among serum levels of ammonia, IL-6 and IL-18.  Results  The levels of serum IL-6, IL-18 and blood ammonia in the non-HE and HE groups were higher than those in the healthy group (P < 0.05). The levels of serum IL-6, IL-18 and blood ammonia in the HE group were higher than those in non-HE group (P < 0.05). Logistic regression analysis showed that high serum levels of IL-6, IL-18, total bilirubin (TBIL) and long prothrombin time (PT) were risk factors for cirrhosis-related HE (P < 0.05). Pearson correlation analysis showed that serum IL-6 was positively correlated with serum ammonia level (r=0.690, P < 0.001, 95% CI: 0.518-0.808), and IL-18 was positively correlated with blood ammonia level (r=0.667, P < 0.001, 95% CI: 0.487-0.793).  Conclusion  High serum levels of IL-6, IL-18, TBIL and long PT are risk factors for hepatocirrhosis-related HE, and serum IL-6 and IL-18 levels are positively correlated with the average level of blood ammonia.

     

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    • References(19)
  • [1]
    ZHUGE W S, ZHUGE Q C, WANG W K, et al. Hydrogen sulphide ameliorates dopamine-induced astrocytic inflammation and neurodegeneration in minimal hepatic encephalopathy[J]. J Cell Mol Med, 2020, 24(23): 13634-13647. doi: 10.1111/jcmm.15728
    [2]
    关珂, 杨婷婷, 杨阳, 等. 1例肝性脑病营养支持实施的病例报道[J]. 中华全科医学, 2021, 19(2): 336-338. doi: 10.16766/j.cnki.issn.1674-4152.001803

    GUAN K, YANG T T, YANG Y, et al. A case report of nutritional support for hepatic encephalopathy[J]. Chinese Journal of General Practice, 2021, 19(2): 336-338. doi: 10.16766/j.cnki.issn.1674-4152.001803
    [3]
    MANZHALII E, VIRCHENKO O, FALALYEYEVA T, et al. Hepatic encephalopathy aggravated by systemic inflammation[J]. Dig Dis, 2019, 37(6): 509-517. doi: 10.1159/000500717
    [4]
    贾继东, 李兰娟. 慢性乙型肝炎防治指南(2010年版)[J]. 实用肝脏病杂志, 2011, 16(1): 2-16. https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201603038.htm

    JIA J D, LI L J. Guidelines for Chronic Hepatitis B (2010 Edition)[J]. Journal of Clinical Hepatology, 2011, 16(1): 2-16. https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201603038.htm
    [5]
    中华医学会消化病学分会, 中华医学会肝病学分会. 中国肝性脑病诊治共识意见(2013年, 重庆)[J]. 中华消化杂志, 2014, 33(2): 81-93. https://cdmd.cnki.com.cn/Article/CDMD-10611-1014044856.htm

    Chinese Society of Gastroenterology, Hepatology Branch of Chinese Medical Association. Consensus on Diagnosis and Treatment of hepatic encephalopathy in China (Chongqing, 2013)[J]. Chinese Journal of Digestion, 2014, 33(2): 81-93. https://cdmd.cnki.com.cn/Article/CDMD-10611-1014044856.htm
    [6]
    BAI Z H, BERNARDI M, YOSHIDA E M, et al. Albumin infusion may decrease the incidence and severity of overt hepatic encephalopathy in liver cirrhosis[J]. Aging (Albany NY), 2019, 11(19): 8502-8525.
    [7]
    LUO S H, CHU J G, HUANG H, et al. Targeted puncture of left branch of intrahepatic portal vein in transjugular intrahepatic portosystemic shunt to reduce hepatic encephalopathy[J]. World J Gastroenterol, 2019, 25(9): 1088-1099. doi: 10.3748/wjg.v25.i9.1088
    [8]
    AMPUERO J, GIL A, VILORIA M D M, et al. Oral glutamine challenge is a marker of altered ammonia metabolism and predicts the risk of hepatic encephalopathy[J]. Liver Int, 2020, 40(4): 921-930. doi: 10.1111/liv.14297
    [9]
    LABENZ C, TOENGES G, HUBER Y, et al. Raised serum Interleukin-6 identifies patients with liver cirrhosis at high risk for overt hepatic encephalopathy[J]. Aliment Pharmacol Ther, 2019, 50(10): 1112-1119. doi: 10.1111/apt.15515
    [10]
    FURUTAMA D, MATSUDA S, YAMAWAKI Y, et al. IL-6 Induced by periodontal inflammation causes neuroinflammation and disrupts the blood-brain barrier[J]. Brain Sci, 2020, 10(10): 679. doi: 10.3390/brainsci10100679
    [11]
    CHEN C, LIU Y H, CHENG S B, et al. The hepatoprotective effects of XCHD and MgIG against methotrexate-induced liver injury and inflammation in rats through suppressing the activation of AIM2 inflammasomes[J]. Pathol Res Pract, 2020, 216(4): 152875. doi: 10.1016/j.prp.2020.152875
    [12]
    YAP J K Y, PICKARD B S, CHAN E W L, et al. The role of neuronal NLRP1 inflammasome in Alzheimer ' s disease: bringing neurons into the neuroinflammation game[J]. Mol Neurobiol, 2019, 56(11): 7741-7753. doi: 10.1007/s12035-019-1638-7
    [13]
    KONG E L, ZHANG J M, AN N, et al. Spironolactone rescues renal dysfunction in obstructive jaundice rats by upregulating ACE2 expression[J]. J Cell Commun Signal, 2018, 13(1): 17-26.
    [14]
    李丹, 张才江. 溶血磷脂酸受体, 自分泌运动因子在肝硬化肝性脑病患者中的表达及意义[J]. 肝脏, 2020, 25(3): 313-316. doi: 10.3969/j.issn.1008-1704.2020.03.027

    LI D, ZHANG C J. Expression and significance of lysophosphatidic acid receptor and autocrine motility factor in patients with cirrhosis and hepatic encephalopathy[J]. Chinese Hepatology, 2020, 25(3): 313-316. doi: 10.3969/j.issn.1008-1704.2020.03.027
    [15]
    SEPEHRINEZHAD A, ZARIFKAR A, NAMVAR G, et al. Astrocyte swelling in hepatic encephalopathy: molecular perspective of cytotoxic edema[J]. Metab Brain Dis, 2020, 35(4): 559-578. doi: 10.1007/s11011-020-00549-8
    [16]
    ANAMIKA F, TRIGUN S K. Sirtuin-3 activation by honokiol restores mitochondrial dysfunction in the hippocampus of the hepatic encephalopathy rat model of ammonia neurotoxicity[J]. J Biochem Mol Toxicol, 2021, 35(5): e22735. DOI: 10.1002/jbt.22735.
    [17]
    CHENG L, WANG X Y, MA X N, et al. Effect of dihydromyricetin on hepatic encephalopathy associated with acute hepatic failure in mice[J]. Pharm Biol, 2021, 59(1): 557-564.
    [18]
    李乐辉, 吴国平, 林润. 血清Trp联合血氨检测提高急诊ICU肝性脑病早期诊断灵敏度的临床价值[J]. 肝脏, 2019, 24(4): 415-417. doi: 10.3969/j.issn.1008-1704.2019.04.022

    LI L H, WU G P, LIN R. Clinical value of serum Trp combined with ammonia detection to improve the sensitivity of early diagnosis of hepatic encephalopathy in emergency ICU[J]. Chinese Hepatology, 2019, 24(4): 415-417. doi: 10.3969/j.issn.1008-1704.2019.04.022
    [19]
    中华医学会肝病学分会. 肝硬化肝性脑病诊疗指南[J]. 传染病信息, 2018, 31(5): 403-420. doi: 10.3969/j.issn.1007-8134.2018.05.003

    Hepatology Branch of Chinese Medical Association. Guidelines on the management of hepatic encephalopathy in cirrhosis[J]. Infectious Disease Information, 2018, 31(5): 403-420. doi: 10.3969/j.issn.1007-8134.2018.05.003
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