Volume 21 Issue 2
Feb.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 288-291
ZHANG Su-yuan, LI Wen-wen, ZHU Ya-qi, LI Xiao-quan. Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy[J]. Chinese Journal of General Practice, 2023, 21(2): 288-291. doi: 10.16766/j.cnki.issn.1674-4152.002866
Citation: ZHANG Su-yuan, LI Wen-wen, ZHU Ya-qi, LI Xiao-quan. Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy[J]. Chinese Journal of General Practice, 2023, 21(2): 288-291. doi: 10.16766/j.cnki.issn.1674-4152.002866
shu

Correlation analysis of serum IL-6, IL-18 and blood ammonia level in patients with hepatic encephalopathy

doi: 10.16766/j.cnki.issn.1674-4152.002866
  • 1.

    Department of Clinical Laboratory, Rongjun Hospital of Henan Province, Xinxiang, Henan 453000, China

Funds:

 LHGJ20190529

  • Received Date: 2022-02-18
    Available Online: 2023-04-20
    Abstract
  •   Objective  The clinical data of patients with liver cirrhosis-related hepatic encephalopathy (HE) were collected, and the correlation among serum interleukin-6 (IL-6), interleukin-18 (IL-18) and blood ammonia levels in patients with HE was analysed retrospectively.  Methods  A total of 95 patients with liver cirrhosis were selected in Rongjun Hospital of Henan province from June 2019 to January 2021. Among them, 41 patients with simple liver cirrhosis were set as non-HE group, and 54 patients with liver cirrhosis and HE were set as HE group. Another 50 healthy persons from our hospital were selected as the health group in the same period. The levels of serum ammonia, IL-6 and IL-18 were compared among the three groups. Differences in the clinical data between HE and non-HE groups were compared, and the risk factors of HE were determined by logistic regression analysis. Pearson correlation analysis was used to evaluate the correlation among serum levels of ammonia, IL-6 and IL-18.  Results  The levels of serum IL-6, IL-18 and blood ammonia in the non-HE and HE groups were higher than those in the healthy group (P < 0.05). The levels of serum IL-6, IL-18 and blood ammonia in the HE group were higher than those in non-HE group (P < 0.05). Logistic regression analysis showed that high serum levels of IL-6, IL-18, total bilirubin (TBIL) and long prothrombin time (PT) were risk factors for cirrhosis-related HE (P < 0.05). Pearson correlation analysis showed that serum IL-6 was positively correlated with serum ammonia level (r=0.690, P < 0.001, 95% CI: 0.518-0.808), and IL-18 was positively correlated with blood ammonia level (r=0.667, P < 0.001, 95% CI: 0.487-0.793).  Conclusion  High serum levels of IL-6, IL-18, TBIL and long PT are risk factors for hepatocirrhosis-related HE, and serum IL-6 and IL-18 levels are positively correlated with the average level of blood ammonia.

     

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