Volume 21 Issue 2
Feb.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 225-230
XU Wei, LI You, FANG Yu-kun, LI Yu, CHEN Qing-yong, WANG Jian, CHEN Yu. Diagnostic value of rapid on-site evaluation of biopsy specimens during medical thoracoscopy for undiagnosed pleural effusion[J]. Chinese Journal of General Practice, 2023, 21(2): 225-230. doi: 10.16766/j.cnki.issn.1674-4152.002851
Citation: XU Wei, LI You, FANG Yu-kun, LI Yu, CHEN Qing-yong, WANG Jian, CHEN Yu. Diagnostic value of rapid on-site evaluation of biopsy specimens during medical thoracoscopy for undiagnosed pleural effusion[J]. Chinese Journal of General Practice, 2023, 21(2): 225-230. doi: 10.16766/j.cnki.issn.1674-4152.002851
shu

Diagnostic value of rapid on-site evaluation of biopsy specimens during medical thoracoscopy for undiagnosed pleural effusion

doi: 10.16766/j.cnki.issn.1674-4152.002851
  • 1.

    Department of Respiratory and Critical Care Medicine, the 903th Hospital of People's Liberation Army, Hangzhou, Zhejiang 310004, China

Funds:

 LGF19H010002

 LGF20H010007

  • Received Date: 2022-02-07
    Available Online: 2023-04-20
    Abstract
  •   Objective  This study aims to investigate the diagnostic value of manifestations in medical thoracoscopy and multi-site biopsy combined with rapid on-site evaluation (ROSE) in undiagnosed pleural effusion.  Methods  The clinical data of 124 patients with undiagnosed pleural effusion who underwent medical thoracoscopy from June 2016 to December 2017 in the 903th Hospital of People's Liberation Army were analyzed retrospectively. The safety, effectiveness and accuracy of thoracoscopy combined with ROSE in clinical application were systematically analyzed and evaluated by observing pleural changes under thoracoscope, rapid field cytological manifestations of biopsies during operation and comparing with the final pathological diagnosis.  Results  Among the 124 patients who underwent thoracoscopy, 77 cases were benign, 41 cases were malignant, and 6 cases were uncertain. The positive predictive value was 73.81%, the negative predictive value was 86.84%, the sensitivity was 75.60%, the specificity was 85.71%, and the coincidence rate with pathological diagnosis was 82.2%. The positive predictive value, negative predictive value, sensitivity and specificity were 82.98%, 97.18%, 95.12% and 89.61% in the diagnosis of malignant pleural effusion by thoracoscopy combined with ROSE (Kappa value was 0.825, P < 0.001), respectively.  Conclusion  Medical thoracoscopy have the characteristics of high detection rate and high accuracy in pleural effusion, and ROSE technique have a good consistency with the final pathological results. The combination of the two techniques can further improve the diagnostic efficiency of undiagnosed pleural effusion, which is worthy of clinical application.

     

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