Volume 20 Issue 12
Dec.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(12): 2068-2070
GONG Li, ZHAO Jing, CHEN Shu-xin, CUI Huan-huan, LIU Jing. Risk factors of gestational diabetes mellitus in advanced age and analysis of maternal and infant outcomes[J]. Chinese Journal of General Practice, 2022, 20(12): 2068-2070. doi: 10.16766/j.cnki.issn.1674-4152.002771
Citation: GONG Li, ZHAO Jing, CHEN Shu-xin, CUI Huan-huan, LIU Jing. Risk factors of gestational diabetes mellitus in advanced age and analysis of maternal and infant outcomes[J]. Chinese Journal of General Practice, 2022, 20(12): 2068-2070. doi: 10.16766/j.cnki.issn.1674-4152.002771
shu

Risk factors of gestational diabetes mellitus in advanced age and analysis of maternal and infant outcomes

doi: 10.16766/j.cnki.issn.1674-4152.002771

  • Department of Endocrinology, Huishan District People' s Hospital, Wuxi City, Wuxi, Jiangsu 214100, China

Funds:

 2017YFC1309800

  • Received Date: 2021-12-01
    Available Online: 2023-02-07
    Abstract
  •   Objective  To explore the risk factors and maternal and infant outcomes of gestational diabetes mellitus (GDM) in this area.  Methods  Data of 938 pregnant women who were treated in Huishan District People' s Hospital of Wuxi City from September 2017 to December 2020 were collected in this study. Based on the oral glucose tolerance fest results, they were divided into four groups: group A [advanced age (≥ 35 years) GDM group, 64 cases], group B (non-advanced age GDM group, 188 cases), group C (advanced age non-GDM group, 112 cases), and group D (non- advanced age non-GDM group, 574 cases). The baseline data of four groups of pregnant women were compared. Taking the occurrence of GDM as the dependent variable, the independent risk factors of advanced age GDM were further analysed by logistic factors and a comparative analysis was carried out. The chi-square test was used to compare the differences in maternal and infant outcomes among the four groups.  Results  The elderly accounted for 25.40% (64/252) of all GDMs. The BMI (27.89±8.74), the proportion of pregnancies with more than one parity (87.5%), the proportion of macrosomia (25.00%) and the proportion of family history of DM (12.50%) in the elderly GDM group were significantly higher than those in the elderly non-GDM group (25.59±2.56, 53.57%, 8.93% and 3.57%). 25(OH)D3 in the elderly GDM group [17.76 (14.71, 20.00) ng/mL] was significantly lower than that in the elderly non GDM group [21.34 (15.10, 30.13) ng/mL]. Multivariate analysis showed that serum 25(OH)D3 level (OR=0.901, 95% CI: 0.815-0.996) and pregnancy of more than one parity (OR=6.412, 95% CI: 1.559-26.380) were independent influencing factors for the occurrence of GDM in the elderly parturient population, of which 25(OH)D3 was negatively related. The caesarean section rate (15.63%), polyhydramnios rate (12.50%) and macrosomia delivery rate (9.38%) of the elderly GDM group were significantly higher than those in the of the elderly non-GDM group (3.57%, 3.57% and 1.79%).  Conclusion  The detection rate of gestational diabetes in elderly pregnant women is high. The 25(OH)D3 in the third trimester and pregnancies over one parity are independent influencing factors for the occurrence of GDM in the population of elderly pregnant women. Hence, the higher maternal and infant pregnancy outcomes of elderly pregnant women with GDM deserve more clinical attention.

     

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