Volume 20 Issue 11
Nov.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(11): 1852-1855
CUI Yan-yan, KE Xi-quan, WANG Qi-zhi, YAN Shan-jun, WANG Qiang-wu, WANG Jian-chao, LI Da-peng. Drug resistance of Helicobacter pylori in 120 patients with digestive tract diseases in Northern Anhui Province[J]. Chinese Journal of General Practice, 2022, 20(11): 1852-1855. doi: 10.16766/j.cnki.issn.1674-4152.002718
Citation: CUI Yan-yan, KE Xi-quan, WANG Qi-zhi, YAN Shan-jun, WANG Qiang-wu, WANG Jian-chao, LI Da-peng. Drug resistance of Helicobacter pylori in 120 patients with digestive tract diseases in Northern Anhui Province[J]. Chinese Journal of General Practice, 2022, 20(11): 1852-1855. doi: 10.16766/j.cnki.issn.1674-4152.002718
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Drug resistance of Helicobacter pylori in 120 patients with digestive tract diseases in Northern Anhui Province

doi: 10.16766/j.cnki.issn.1674-4152.002718

  • Department of Gastroenterology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 gxgwfx2018052

  • Received Date: 2022-04-26
    Available Online: 2022-12-30
    Abstract
  •   Objective  To investigate the drug resistance of Helicobacter pylori (HP) to commonly used antibiotics and its influencing factors in Northern Anhui Province, understand the drug resistance spectrum of HP in this area, and provide a basis for the selection of the best treatment plan for eradication of HP.  Methods  A total of 120 patients who were positive for both 13C-urea breath test (or 14C-urea breath test) and rapid urease test in the First Affiliated Hospital of Bengbu Medical College from January 2020 to June 2021 were selected. HP was isolated and identified by microaerobic culture. The drug resistance of HP to amoxicillin, clarithromycin, metronidazole, levofloxacin and furazolidone was detected using the HP drug sensitivity detection kit method, and the drug resistance of HP isolated from patients with different genders, ages and disease categories to the above antibiotics was further compared and analysed.  Results  A total of 55 strains of HP were cultured from 120 patients with a positive rate of 45.83%. There was no significant difference in the HP culture positive rate among patients of different genders and ages (P>0.05), and the positive rate of HP culture in peptic ulcer patients was significantly higher than that in gastritis and gastric cancer patients (P < 0.017). The drug resistance rates of HP to amoxicillin, clarithromycin, metronidazole, levofloxacin and furazolidone were 3.64%, 27.27%, 65.45%, 30.91% and 1.82%, respectively. There were no statistically significant differences in HP resistance levels among different genders, age stages and disease types (all P>0.05).  Conclusion  The resistance rate of HP strains to metronidazole, clarithromycin and levofloxacin is high in Northern Anhui Province, but the resistance rate to amoxicillin and furazolidone is low. When antibiotics are used to eradicate HP in Northern Anhui Province, sensitive antibiotics are used for empirical treatment as far as possible.

     

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