Volume 20 Issue 10
Oct.  2022
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LI Yan-hui, ZHAO Chen-xi, CHEN Ming, YANG Shuang-ling, XUE Xian-jun. Application value of ultrasound in adult patients with thyroid nodules ≥3 cm[J]. Chinese Journal of General Practice, 2022, 20(10): 1742-1745. doi: 10.16766/j.cnki.issn.1674-4152.002693
Citation: LI Yan-hui, ZHAO Chen-xi, CHEN Ming, YANG Shuang-ling, XUE Xian-jun. Application value of ultrasound in adult patients with thyroid nodules ≥3 cm[J]. Chinese Journal of General Practice, 2022, 20(10): 1742-1745. doi: 10.16766/j.cnki.issn.1674-4152.002693

Application value of ultrasound in adult patients with thyroid nodules ≥3 cm

doi: 10.16766/j.cnki.issn.1674-4152.002693
Funds:

 LHGJ20191377

  • Received Date: 2021-09-21
    Available Online: 2022-11-30
  •   Objective  To clarify the difference of ultrasound (US) images between ≥3.0 cm thyroid nodules (TNS) and < 3.0 cm TNS, and to explore the application value of US in patients with ≥3.0 cm thyroid nodules.  Methods  From March 2017 to August 2019, 545 patients underwent US examination and thyroid surgery in the Shenma Medical Group General Hospital, Sanquan College, and Oilfield General Hospital of Puyang City were selected and divided into the large nodule group (115 cases, 152 nodules) and small nodule group (352 cases, 417 nodules) according to the maximum diameter of thyroid nodules. The large nodule group comprised patients with thyroid nodules ≥ 3.0 cm, whereas patients with thyroid nodules < 3.0 cm were in the small nodule group. The clinical and US imaging features were compared between the two groups.  Results  (1) The microcalcification rate (28.94%), hypoechoic rate (40.13%) and irregular shape rate (13.82%) in patients with large nodules were higher than those in patients with small nodules (18.94%, 7.19% and 3.36%, respectively, all P < 0.05). The cystic structure rate (9.21%), mixed nodule rate (30.26%), hyperechoic rate (30.92%) and perinodal vascular rate (4.61%) in patients with large nodules were lower than those in patients with small nodules (18.94%, 48.44%, 42.93% and 13.43%, respectively, all P < 0.05). (2) No significant difference was found between the diagnosis results of TI-RADS classification of large thyroid nodules and small thyroid nodules (P>0.05). (3) The correct rate of US in diagnosing large thyroid nodules was 74.3% (113/152). Large nodules were the risk factors of malignant thyroid nodules (OR=2.674, 95% CI: 1.116-6.405, P=0.027).  Conclusion  There are differences in US characteristics between patients with TNS ≥3.0 cm and patients with TNS < 3.0 cm. Compared with small thyroid nodules, large thyroid nodules have a higher risk of malignant transformation.

     

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  • [1]
    尹丽萍, 万梦, 王晓华, 等. 某三甲医院健康体检人群甲状腺结节检出率及影响因素分析[J]. 安徽医学, 2021, 42(8): 941-944. doi: 10.3969/j.issn.1000-0399.2021.08.028

    YIN L P, WAN M, WANG X H. Analysis of thyroid nodule detection rate and factors among healthy physical examination population in Hefeidistrict[J]. Anhui Medical Journal, 2021, 42(8): 941-944. doi: 10.3969/j.issn.1000-0399.2021.08.028
    [2]
    贾颖超, 杨章慧, 吕信笑, 等. 多种超声征象联合检测在甲状腺结节良恶性病变中的鉴别应用价值[J]. 中华全科医学, 2018, 16(5): 816-819. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201805040.htm

    JIA Y C, YANG Z H, LYU X X, et al. The value of differential diagnosis of multiple ultrasonography in the detection of benign and malignant thyroid nodules[J]. Chinese Journal of General Practice, 2018, 16(5): 816-819. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201805040.htm
    [3]
    任明, 高国宇, 郭嵩. 纳米碳对甲状腺癌手术中甲状旁腺的保护作用[J]. 中国普通外科杂志, 2017, 26(11): 1489-1493. doi: 10.3978/j.issn.1005-6947.2017.11.019

    REN M, GAO G Y, GUO S. Pvotective effect of carbon nanoparticles on parathyroid gland in thyroid carcinoma surgery[J]. Chinese Journal of General Surgery, 2017, 26(11): 1489-1493. doi: 10.3978/j.issn.1005-6947.2017.11.019
    [4]
    刘琪, 王德伟. 精细化甲状腺被膜解剖技术联合环甲隙显露喉返神经方法在分化型甲状腺癌中的应用价值[J]. 中国普通外科杂志, 2020, 29(5): 635-640. https://www.cnki.com.cn/Article/CJFDTOTAL-ZPWZ202005022.htm

    LIU Q, WANG D W. Application of meticulous capsular dissection technique combined with exposure of recurrent laryngeal nerve in the cricoid thyroid space in treatment of differentiated thyroid carcinoma[J]. Chinese Journal of General Surgery, 2020, 29(5): 635-640. https://www.cnki.com.cn/Article/CJFDTOTAL-ZPWZ202005022.htm
    [5]
    RAGUIN T, SCHNEEGANS O, RODIER J F, et al. Value of fine-needle aspiration in evaluating large thyroid nodules[J]. Head & Neck, 2017, 39(1): 32-36.
    [6]
    CAI W J, LIU S S, YU X L, et al. Is partial ablation appropriate for benign thyroid nodules? A retrospective study with long-term follow-up after microwave ablation[J]. Int J Hyperthermia, 2021, 38(1): 923-930. doi: 10.1080/02656736.2021.1936217
    [7]
    李梅, 蔡建珊, 杨茹怡, 等. 静安区居民甲状腺结节的超声筛查结果及患病情况分析[J]. 中国医学计算机成像杂志, 2017, 23(4): 370-374. doi: 10.3969/j.issn.1006-5741.2017.04.018

    LI MEI, CAI J S, YANG R Y, et al. Ultrasonographic findings and prevalence of thyroid nodules in residents of Jing' an district[J]. Chinese Computed Medical Imaging, 2017, 23(4): 370-374. doi: 10.3969/j.issn.1006-5741.2017.04.018
    [8]
    陈柳洁, 陈泽华, 张凌. 甲状腺超声影像和数据报告系统在诊断不同性别和年龄甲状腺结节患者中的应用价值分析[J]. 现代医用影像学, 2020, 29(1): 103-105. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYY202001043.htm

    CHEN L J, CHEN Z H, ZHANG L. Application value of thyroid ultrasound imaging and data reporting system in the diagnosis of thyroid nodules of different genders and ages[J]. Modern Medical Imageology, 2020, 29(1): 103-105. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYY202001043.htm
    [9]
    韩蕊君, 杜晶, 陈翠, 等. 超声TI-RADS分级联合三维剪切波弹性成像对甲状腺微小癌的诊断效能[J]. 上海交通大学学报(医学版), 2020, 40(1): 76-80. https://www.cnki.com.cn/Article/CJFDTOTAL-SHEY202001018.htm

    HAN R J, DU J, CHEN C, et al. Diagnostic efficiency of ultrasound TI-RADS combined with three-dimensional shear wave elastography in thyroid microcarcinoma[J]. Journal of Shanghai Jiaotong University(Medical Science), 2020, 40(1): 76-80. https://www.cnki.com.cn/Article/CJFDTOTAL-SHEY202001018.htm
    [10]
    胡珂, 陆志强, 董怡, 等. 甲状腺良性大结节射频和微波消融治疗的近期安全性和有效性分析[J]. 复旦学报(医学版), 2017, 44(4): 417-421. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYK201704004.htm

    HU K, LU Z Q, DONG Y, et al. Short-term safety and efficacy of radiofrequency ablation vs. microwave ablation for patients with large benign thyroid nodules[J]. Fudan University Journal of Medical Sciences, 2017, 44(4): 417-421. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYK201704004.htm
    [11]
    NAM S J, KWAK J Y, MOON H J, et al. Large (≥3 cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?[J]. PLoS One, 2017, 12(10): e0186242. DOI: 10.1371/journal.pone.0186242.
    [12]
    李梅, 蔡建珊, 杨茹怡, 等. 静安区居民甲状腺结节的超声筛查结果及患病情况分析[J]. 中国医学计算机成像杂志, 2017, 23(4): 370-374. https://www.cnki.com.cn/Article/CJFDTOTAL-YJTY201704021.htm

    LI M, CAI J S, YANG R Y, et al. Ultrasonographic findings and prevalence of thyroid nodules in residents of Jing' an district[J]. Chinese Computed Medical Imaging, 2017, 23(4): 370-374. https://www.cnki.com.cn/Article/CJFDTOTAL-YJTY201704021.htm
    [13]
    YIN L, ZHANG W, BAI W K, et al. Relationship between morphologic characteristics of ultrasonic calcification in thyroid nodules and thyroid carcinoma[J]. Ultrasound Med Biol, 2020, 46(1): 20-25.
    [14]
    FANG D, MA W T, XU L, et al. A predictive model to distinguish papillary thyroid carcinomas from benign thyroid nodules using ultrasonographic features: A single-center, retrospective analysis[J]. Med Sci Monit, 2019, 25(7): 9409-9415.
    [15]
    CHO M J, HAN K, SHIN I, et al. Intranodular vascularity may be useful in predicting malignancy in thyroid nodules with the intermediate suspicion pattern of the 2015 American Thyroid Association Guidelines[J]. Ultrasound Med Biol, 2020, 46(6): 1373-1379.
    [16]
    张贺香, 胡萍香, 胡业深, 等. TI-RADS分类量化评分在鉴别甲状腺结节良恶性中的应用[J]. 中国中西医结合影像学杂志, 2017, 15(3): 300-301, 304. https://www.cnki.com.cn/Article/CJFDTOTAL-JHYX201703013.htm

    ZHANG H X, HU P X, HU Y S, et al. TI-RADS classification and scores in diagnosis of benign and malignant thyroid nodules[J]. Chinese Imaging Journal of Integrated Traditional and Western Medicine, 2017, 15(3): 300-301, 304. https://www.cnki.com.cn/Article/CJFDTOTAL-JHYX201703013.htm
    [17]
    BESTEPE N, OZDEMIR D, BASER H, et al. Is thyroid nodule volume predictive for malignancy?[J]. Arch Endocrinol Metab, 2019, 63(4): 337-344.
    [18]
    ZARGHAM R, JOHNSON H, ANDERSON S, et al. Conditions associated with the need for additional needle passes in ultrasound-guided thyroid fine-needle aspiration with rapid on-site pathology evaluation[J]. Diagn Cytopathol, 2021, 49(1): 105-108.
    [19]
    HONG M J, NA D G, BAEK J H, et al. Impact of nodule size on malignancy risk differs according to the ultrasonography pattern of thyroid nodules[J]. Korean J Radiol, 2018, 19(3): 534-541.
    [20]
    GOUNDAN P N, MAMOU J, ROHRBACH D, et al. A preliminary study of quantitative ultrasound for cancer-risk assessment of thyroid nodules[J]. Front Endocrinol (Lausanne), 2021, 12(7): 627698.
    [21]
    HUANG K, GAO N N, ZHAI Q X, et al. The anteroposterior diameter of nodules in the risk assessment of papillary thyroid microcarcinoma[J]. Medicine (Baltimore), 2018, 97(10): e9712. DOI: 10.1097/MD.0000000000009712.
    [22]
    BILGINER M C, OZDEMIR D, BASER H, et al. Is ultrasonographically detected nodule diameter concordant with pathological tumor size?[J]. Int J Surg, 2017, 42(5): 95-102.
    [23]
    LIN W C, KAN N N, CHEN H L, et al. Efficacy and safety of single-session radiofrequency ablation for benign thyroid nodules of different sizes: A retrospective study[J]. Int J Hyperthermia, 2020, 37(1): 1082-1089.
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