Volume 20 Issue 8
Aug.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(8): 1287-1290
LIANG Bo, GAO Jin-ping, ZHANG Shu-mei. Analysis of clinical features and results of Dsg1 and Dsg3 antibodies in patients with pemphigus[J]. Chinese Journal of General Practice, 2022, 20(8): 1287-1290. doi: 10.16766/j.cnki.issn.1674-4152.002578
Citation: LIANG Bo, GAO Jin-ping, ZHANG Shu-mei. Analysis of clinical features and results of Dsg1 and Dsg3 antibodies in patients with pemphigus[J]. Chinese Journal of General Practice, 2022, 20(8): 1287-1290. doi: 10.16766/j.cnki.issn.1674-4152.002578
shu

Analysis of clinical features and results of Dsg1 and Dsg3 antibodies in patients with pemphigus

doi: 10.16766/j.cnki.issn.1674-4152.002578

  • Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China

Funds:

 82073438

 2020xkj154

  • Received Date: 2021-07-18
    Available Online: 2022-09-26
    Abstract
  •   Objective   Methods To investigate the clinical features of pemphigus patients and analyse the correlation between the results of ELISA test on desmoglein 1 (Dsg1) antibody and Desmoglein 3 (Dsg3) antibody and the type and severity of pemphigus.  Methods  Fifty patients with pemphigus were selected from the First Affiliated Hospital of Anhui Medical University in 2021. The patients were classified and graded based on clinical manifestation and laboratory indexes. Retrospective analysis was conducted on the inducing factors, complications, skin infection status and Dsg1 and Dsg3 antibody titres.  Results  A total of 39 cases of pemphigus vulgaris, 8 cases of pemphigus erythematous, 2 cases of pemphigus foliaceus and 1 case of paraneoplastic pemphigus were confirmed amongst these 50 patients. Amongst them, 28 cases were mild, 11 cases were medium and 11 cases were severe. One of the common inducing factors was found to be the non-standard use of glucocorticoid, accounting for 20% (10/50) of all cases. The most common skin infection-related bacterium was Staphylococcus aureus, which was detected in 18% (9/50) of all cases. Amongst different types of patients with pemphigus, significant differences in Dsg3 antibody indexes were found (Z=-3.481, P < 0.001). In addition, there was a significant difference between the groups in patients with varying severity (P=0.002, 0.024).  Conclusion  Proper use of glucocorticoids is required in the treatment of pemphigus. Skin infection was found to be common in patients with pemphigus. The detection of Dsg1 and Dsg3 antibodies shows good sensitivity for pemphigus diagnosis, and the titres of these two types of antibodies can be utilised as indicators for the evaluation of pemphigus.

     

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