Volume 20 Issue 4
Apr.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 623-625
XIANG Qiong-lian, ZHU Li-juan, ZHANG Shi-hai. Clinical significance of serum amyloid protein A and interleukin-6 expression in hand, foot and mouth disease on the basis of propensity score matching[J]. Chinese Journal of General Practice, 2022, 20(4): 623-625. doi: 10.16766/j.cnki.issn.1674-4152.002415
Citation: XIANG Qiong-lian, ZHU Li-juan, ZHANG Shi-hai. Clinical significance of serum amyloid protein A and interleukin-6 expression in hand, foot and mouth disease on the basis of propensity score matching[J]. Chinese Journal of General Practice, 2022, 20(4): 623-625. doi: 10.16766/j.cnki.issn.1674-4152.002415
shu

Clinical significance of serum amyloid protein A and interleukin-6 expression in hand, foot and mouth disease on the basis of propensity score matching

doi: 10.16766/j.cnki.issn.1674-4152.002415

  • Department of Clinical Laboratory, Anhui Provincial Children's Hospital, Hefei, Anhui 230051, China

Funds:

 320.6750.17377

  • Received Date: 2021-01-05
    Available Online: 2022-08-20
    Abstract
  •   Objective  To investigate the expression of serum amyloid A (SAA) and interleukin-6 (IL-6) in different types of hand, foot and mouth disease (HFMD).  Methods  A total of 216 children with HFMD admitted to Anhui Provincial Children's Hospital from Jan. 2017 to Nov. 2020 were randomly selected as the observation objects, including 145 children with common HFMD and 71 children with severe HFMD. Propensity score matching method was used for 1∶ 1 matching. The matching variables included age, gender, course of disease, blood collection time after admission, cough, runny nose, loss of appetite and other clinical manifestations. The distribution of enterovirus 71 (EV-A71) RNA in the faeces of HFMD patients was observed by reverse transcription polymerase chain reaction. The expression of SAA and IL-6 in venous blood of children with different types of HFMD were observed.  Results  The expression levels of SAA and IL-6 in patients with severe HFMD and common HFMD were (162.50±11.23) mg/L vs. (10.28±2.06) mg/L and (49.96±6.85) pg/mL vs. (23.11±4.98) pg/mL, respectively. The expression levels of SAA and IL-6 in the severe HFMD group were higher than those in the common HFMD group (all P < 0.01). The positive rate of EV-A71 in the severe HFMD group was significantly higher than that in the normal HFMD group (χ2=9.100, P=0.003). The expression levels of IL-6 and SAA in patients with EV-A71-positive HFMD were significantly higher than those in patients with EV-A71-negative HFMD in both groups (all P < 0.01). The expression levels of SAA and IL-6 in the EV-A71-positive HFMD group and EV-A71-negative HFMD group were (93.65±6.71) mg/L vs. (80.40±5.83) mg/L and (45.57±5.88) pg/mL vs. (28.37±3.15) pg/mL, respectively. The expression levels of serum SAA and IL-6 in the EV-A71-positive HFMD group were higher than those in the EV-A71-negative HFMD group (all P < 0.01).  Conclusion  SAA and IL-6 are involved in the pathogenesis of HFMD and closely related to HFMD typing and EV-A71 expression.

     

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