Volume 20 Issue 3
Mar.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 431-434
FAN Min, CHEN Xin, ZHANG Zhen, JIA Wen-ting. Clinical characteristics and risk factors of feeding intolerance in preterm infants[J]. Chinese Journal of General Practice, 2022, 20(3): 431-434. doi: 10.16766/j.cnki.issn.1674-4152.002370
Citation: FAN Min, CHEN Xin, ZHANG Zhen, JIA Wen-ting. Clinical characteristics and risk factors of feeding intolerance in preterm infants[J]. Chinese Journal of General Practice, 2022, 20(3): 431-434. doi: 10.16766/j.cnki.issn.1674-4152.002370
shu

Clinical characteristics and risk factors of feeding intolerance in preterm infants

doi: 10.16766/j.cnki.issn.1674-4152.002370
  • 1.

    Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0378

  • Received Date: 2021-11-08
    Available Online: 2022-08-13
    Abstract
  •   Objective  To analyse the clinical characteristics and related factors of feeding intolerance (FI) in preterm infants.  Methods  A total of 589 preterm infants hospitalised in the first and second affiliated hospitals of Bengbu Medical College from November 2020 to November 2021 were divided into the feeding tolerance (FT) group and FI group. They were divided into < 32 weeks group and ≥32 weeks group according to gestational age. They were divided into groups of < 1 500 g and ≥1 500 g according to birth weight. General information (gender, gestational age, birth weight, asphyxia and medication) and FI (occurrence time, duration and disappearance time) were recorded in detail in the FI group, clinical characteristics of FI were summarised, and risk factors of FI were analysed.  Results  (1) FT accounted for 68.59%, and FI accounted for 31.41%. (2) The main symptoms of FI were abdominal distention, gastric retention and vomiting. (3) The appearance of FI in the group with gestational age < 32 weeks appeared later (P < 0.001), lasted longer (P < 0.001), and disappeared later (P=0.002) than the group with gestational age ≥32 weeks. The difference was statistically significant (P < 0.05), but the difference of main symptoms was not statistically significant (P>0.05). Compared with the ≥1500g group, FI clinical manifestations appeared later (P=0.002), lasted longer (P=0.004) and disappeared later (P < 0.001) in < 1 500 g group. However, the vomiting of premature infants in the ≥1 500 g group was significantly higher than that in the < 1 500 g group (P=0.034). All had statistical significance (P < 0.05). (4) Gestational age and birth weight were protective factors of FI, whereas intrauterine infection and neonatal respiratory distress syndrome were independent risk factors of FI (all P < 0.05).  Conclusion  The younger the gestational age and the lighter the birth weight, the later the occurrence and disappearance time and the longer the duration of FI. Low birth weight and intrauterine infection are independent risk factors of FI.

     

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