Volume 20 Issue 3
Mar.  2022
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PENG Nan, CHENG Chuan-dong, JI Ying, WU Jin-long, RU Xiao-yu, TU Yang, ZHENG Wei-nan. Prognostic factors of pineal region tumors resected by the modified Poppen approach[J]. Chinese Journal of General Practice, 2022, 20(3): 388-390. doi: 10.16766/j.cnki.issn.1674-4152.002359
Citation: PENG Nan, CHENG Chuan-dong, JI Ying, WU Jin-long, RU Xiao-yu, TU Yang, ZHENG Wei-nan. Prognostic factors of pineal region tumors resected by the modified Poppen approach[J]. Chinese Journal of General Practice, 2022, 20(3): 388-390. doi: 10.16766/j.cnki.issn.1674-4152.002359

Prognostic factors of pineal region tumors resected by the modified Poppen approach

doi: 10.16766/j.cnki.issn.1674-4152.002359
Funds:

 15011d04033

 WK9110000032

 1508085QH184

  • Received Date: 2021-02-26
    Available Online: 2022-08-13
  •   Objective  To investigate the factors influencing the prognosis of adult pineal region tumors after microresection via the modified Poppen approach, so as to identify the related factors leading to poor prognosis and improve clinical prognosis of patients.  Methods  Clinical data of adult patients admitted to the Neurosurgery Department of the Provincial Hospital affiliated to the University of Science and Technology of China from June 2015 to July 2020 who underwent microresection of pineal region tumors via the modified Poppen approach were collected and retrospectively analyzed.  Results  A total of 48 patients were collected. The patients received Karnofsky performance score (KPS) index score 1 month after surgery, and were divided into two groups according to the results of KPS score. Those with a KPS score of 70 or above were considered to have a good prognosis, while those with a KPS score of 70 or below were considered to have a poor prognosis, because effective anti-tumor regimens could not be implemented for patients with a KPS score of 70 or below. There were 29 patients with good prognosis and 19 patients with poor prognosis. The results of univariate analysis showed that the amount of blood loss in the poor prognosis group [(466.84±182.18) mL] was higher than that in the good prognosis group [(364.14±123.42) mL]. The incidence of postoperative occipital lobe injury in the poor prognosis group (57.89%, 11/19) was higher than that in the good prognosis group (24.14%, 7/29). However, the results of multivariate Logistic regression analysis showed that postoperative KPS score was only correlated with postoperative occipital lobe injury (OR=4.887) and the relationship between the lesion and the parietal capsule (OR=5.870), but not related to the preoperative KPS score and intraoperative blood loss.  Conclusion  Microresection of brain tumors using the modified Poppen approach can improve the prognosis of patients. The poor prognosis of some patients is related to tumor location, postoperative occipital lobe injury and the amount of blood loss. Excessive traction should be avoided in operation to reduce the possibility of occipital lobe injury. For patients whose tumors are located in front of the parietal cap, the surgical methods should be replaced. Intraoperative reduction of total blood loss may improve patient outcomes.

     

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