Volume 20 Issue 3
Mar.  2022
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FANG Ru-meng, DI Ning-ning, ZHENG Qian-qian, XIE Chang-hao, LI Zhi-jun. Relationship between serum B-cell activating factor expression and carotid atherosclerosis and its related factors in patients with systemic lupus erythematosus[J]. Chinese Journal of General Practice, 2022, 20(3): 371-374. doi: 10.16766/j.cnki.issn.1674-4152.002355
Citation: FANG Ru-meng, DI Ning-ning, ZHENG Qian-qian, XIE Chang-hao, LI Zhi-jun. Relationship between serum B-cell activating factor expression and carotid atherosclerosis and its related factors in patients with systemic lupus erythematosus[J]. Chinese Journal of General Practice, 2022, 20(3): 371-374. doi: 10.16766/j.cnki.issn.1674-4152.002355

Relationship between serum B-cell activating factor expression and carotid atherosclerosis and its related factors in patients with systemic lupus erythematosus

doi: 10.16766/j.cnki.issn.1674-4152.002355
Funds:

 2108085MH258

  • Received Date: 2021-12-08
    Available Online: 2022-08-13
  •   Objective  To explore the relationship between serum B-cell activating factor (BAFF) expression level and carotid atherosclerosis in patients with systemic lupus erythematosus (SLE) and its related factors.  Methods  A total of 103 SLE patients who met the inclusion criteria and were admitted to our department from October 2020 to June 2021 were selected. According to the results of carotid colour Doppler imaging, 103 SLE patients were divided into three groups: group A with arterial plaque formation (32 cases), group B with intima thickening (31 cases) and group C with no arterial disease (40 cases). At the same time, serum samples of healthy people (group D, 40 cases) were selected as the control group. The expression levels of serum BAFF in four groups were detected by enzyme-linked immunosorbent assay. The correlation between BAFF and clinical and laboratory indicators was analysed.  Results  The expression level of BAFF in SLE patients was significantly higher than that in healthy controls [5.73(2.02, 7.89) ng/mL vs. 1.01(0.76, 1.31) ng/mL, Z=-9.265, P < 0.001]. The expression of BAFF in SLE patients in group A was higher than that in groups B and C [14.55(11.44, 20.18) ng/mL vs. 6.33(5.81, 7.45) ng/mL vs. 5.26(4.22, 6.93) ng/mL, Z=55.767, P < 0.001]. Correlation analysis showed that the expression level of BAFF was positively correlated with the course of disease, age, SLEDAI2000, ESR, anti-dsDNA quantisation and IgA and negatively correlated with complement C3 (r=-0.309).  Conclusion  The expression level of serum BAFF in SLE patients is correlated with the occurrence of carotid atherosclerosis, which may be an important factor promoting the formation of atherosclerosis in SLE patients. Serum BAFF level in SLE patients was significantly correlated with SLEDAI and other disease activity indicators, which could be used as a reference indicator to judge the disease activity.

     

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