Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2058-2060, 2152
PU Qiang-hong, LI Jia-meng, LI Fan-min, YUAN Shu-sheng. Risk factors for tuberculosis chemotherapeutic drug pyrazinamide-induced hyperuricemia[J]. Chinese Journal of General Practice, 2021, 19(12): 2058-2060, 2152. doi: 10.16766/j.cnki.issn.1674-4152.002236
Citation: PU Qiang-hong, LI Jia-meng, LI Fan-min, YUAN Shu-sheng. Risk factors for tuberculosis chemotherapeutic drug pyrazinamide-induced hyperuricemia[J]. Chinese Journal of General Practice, 2021, 19(12): 2058-2060, 2152. doi: 10.16766/j.cnki.issn.1674-4152.002236
shu

Risk factors for tuberculosis chemotherapeutic drug pyrazinamide-induced hyperuricemia

doi: 10.16766/j.cnki.issn.1674-4152.002236
  • 1.

    Department of Pharmacy, People's Hospital of Leshan, Leshan, Sichuan 614000, China

Funds:

 17PJ560

 17SZD185

  • Received Date: 2021-02-04
    Abstract
  •   Objective  To evaluate the possible risk factors for hyperuricemia induced by tuberculosis chemotherapeutic drug pyrazinamide.  Methods  Patients who were diagnosed with tuberculosis in the Department of Infection and Department of Respiratory in our hospital from July 2016 to December 2020 were enrolled. The isoniazid, rifampicin, pyrazinamide and ethambutol regimen were administrated daily in intensive period. Data of age, gender, body mass index, smoking history, drinking history and chronic disease history (diabetes, hypertension or coronary heart disease) were collected. The polymorphism of uric acid transporter URAT1 and GLUT9 gene were determined.  Results  No differences in age, sex(male/female: 50/31 vs. 8/9), BMI, smoking history, drinking history and chronic diseases (diabetes, hypertension or coronary heartdisease: 7/74 vs. 3/14) were found between two groups. There was no significant difference in ALT, albumin, total bilirubin and serum creatinine [(55.1±10.9)μmol/L vs. (58.2±12.6)μmol/L] in the two groups. There was no significant difference in the genotypes of URAT1 gene polymorphisms [rs7932775 (t1309c), rs475688, rs3825016 (c258t)] and GLUT9 gene polymorphisms [rs3733591 (r265h), rs1014290] between two groups (all P>0.05).  Conclusion  Age, sex, BMI, smoking history, drinking history, chronic diseases, hepatic and renal function, polymorphisms of URAT1 and GLUT9 gene might not be the risk factors for pyrazinamide-induced hyperuricemia.

     

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    • References(21)
  • [1]
    中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 肺结核基层诊疗指南(2018年)[J]. 中华全科医师杂志, 2019, 18(8): 709-717. doi: 10.3760/cma.j.issn.1671-7368.2019.08.002
    [2]
    TURNBULL L, BELL C, CHILD F. Tuberculosis (NICE clinical guideline 33)[J]. Arch Dis Child Educ Pract Ed, 2017, 102(3): 136-42. doi: 10.1136/archdischild-2016-310870
    [3]
    MANDOVRA N P, LELE T T, VAIDYA P J, et al. High incidence of new-onset joint pain in patients on fluoroquinolones as antituberculous treatment[J]. Respiration, 2020, 99(2): 125-131. doi: 10.1159/000505102
    [4]
    李卉, 张宏亮, 杨天燕, 等. 我院125例抗结核药物不良反应报告分析[J]. 中国医药导报, 2020, 17(29): 151-154. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY202029039.htm
    [5]
    韩冰, 胡柳杨, 姚亚超, 等. 合并糖尿病的结核病患者接受吡嗪酰胺治疗后高尿酸血症、痛风性关节炎发病情况观察[J]. 山东医药, 2020, 60(3): 60-62. doi: 10.3969/j.issn.1002-266X.2020.03.016
    [6]
    杨玫. 吡嗪酰胺对肺结核合并糖尿病患者高尿酸血症发生率及严重程度的影响分析[J]. 中国医药指南, 2019, 17(19): 2-3. https://www.cnki.com.cn/Article/CJFDTOTAL-YYXK201919002.htm
    [7]
    肖建华. 探讨吡嗪酰胺致严重高尿酸血症的影响因素及对抗结核治疗的影响[J]. 国际感染病学(电子版), 2019, 8(1): 120. https://www.cnki.com.cn/Article/CJFDTOTAL-GJGR201901096.htm
    [8]
    金玲玲, 施伎蝉, 蒋贤高, 等. 短程化疗方案在初次复发涂阳肺结核中的效果评价[J]. 中华全科医学, 2019, 17(9): 1508-1511. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201909021.htm
    [9]
    刘占中, 王春颖, 王亮, 等. 吡嗪酰胺不同给药频次的效果及药效学评价[J]. 河北医药, 2020, 42(19): 2981-2983, 2986. doi: 10.3969/j.issn.1002-7386.2020.19.025
    [10]
    韩珂卿, 余林红, 崔嘉佳, 等. 202例患者应用吡嗪酰胺后的不良反应分析[J]. 临床医学研究与实践, 2019, 4(14): 116-117. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS201914046.htm
    [11]
    刘硕, 康万里, 许瑞, 等. 吡嗪酰胺相关高尿酸血症患者血尿酸升高程度的影响因素分析[J]. 药物不良反应杂志, 2020, 22(12): 665-669. doi: 10.3760/cma.j.cn114015-20191225-01067
    [12]
    李媛媛, 苏东栋, 哈米提·努力克. 吡嗪酰胺引起糖尿病合并肺结核患者高尿酸血症的临床观察[J]. 当代医学, 2017, 23(20): 91-92. doi: 10.3969/j.issn.1009-4393.2017.20.045
    [13]
    陈智慧. 吡嗪酰胺对肺结核合并糖尿病患者高尿酸血症发生率及严重程度的影响[J]. 中国医药指南, 2017, 15(34): 131-132. https://www.cnki.com.cn/Article/CJFDTOTAL-YYXK201734105.htm
    [14]
    胡艳, 陶敏, 潘星, 等. 慢性肾脏病人群中高尿酸血症的患病率及危险因素研究[J]. 中华全科医学, 2020, 18(12): 1989-1993. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202012004.htm
    [15]
    ANDRADE SIERRA J, FLORES FONSECA M M. Renal handling of uric acid[J]. Contrib Nephrol, 2018, 192: 1-7.
    [16]
    TU H P, MIN-SHAN KO A, LEE S S, et al. Variants of ALPK1 with ABCG2, SLC2A9, and SLC22A12 increased the positive predictive value for gout[J]. J Hum Genet, 2018, 63(1): 63-70. doi: 10.1038/s10038-017-0368-9
    [17]
    DUONG N T, NGOC N T, THANG N T M, et al. Polymorphisms of ABCG2 and SLC22A12 genes associated with gout risk in vietnamese population[J]. Medicina (Kaunas), 2019, 55(1): 8. doi: 10.3390/medicina55010008
    [18]
    ZOU Y, DU J, ZHU Y, et al. Associations between the SLC22A12 gene and gout susceptibility: A meta-analysis[J]. Clin Exp Rheumatol, 2018, 36(3): 442-447.
    [19]
    WAN ROHANI W T, MAHFUDZAH A, NAZIHAH M Y, et al. Association of solute carrier family 2, member 9 (SLC2A9) genetic variant rs3733591 with gout in a Malay sample set[J]. Med J Malaysia, 2018, 73(5): 307-310.
    [20]
    BEN SALEM C, SLIM R, FATHALLAH N, et al. Drug-induced hyperuricaemia and gout[J]. Rheumatology (Oxford), 2017, 56(5): 679-688.
    [21]
    ICHIDA K, HOSOYAMADA M, KAMATANI N, et al. Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in Japanese[J]. Clin Genet, 2008, 74(3): 243-251. doi: 10.1111/j.1399-0004.2008.01021.x
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