Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2048-2050, 2118
LI Wei-ying, LIN Qing, FU Pan. Expression and significance of plasma Aβ1-40, blood lipid and inflammatory indexes in Alzheimer's disease[J]. Chinese Journal of General Practice, 2021, 19(12): 2048-2050, 2118. doi: 10.16766/j.cnki.issn.1674-4152.002233
Citation: LI Wei-ying, LIN Qing, FU Pan. Expression and significance of plasma Aβ1-40, blood lipid and inflammatory indexes in Alzheimer's disease[J]. Chinese Journal of General Practice, 2021, 19(12): 2048-2050, 2118. doi: 10.16766/j.cnki.issn.1674-4152.002233
shu

Expression and significance of plasma Aβ1-40, blood lipid and inflammatory indexes in Alzheimer's disease

doi: 10.16766/j.cnki.issn.1674-4152.002233

  • Department of Neurology, Taizhou First People's Hospital, Taizhou, Zhejiang 318020, China

Funds:

 2019RC310

  • Received Date: 2020-04-15
    Available Online: 2022-03-02
    Abstract
  •   Objective  To investigate the expression and clinical significance of plasma β-amyloid 1-40 (Aβ1-40), blood lipids and inflammatory indexes in elderly patients with Alzheimer's disease.  Methods  A total of 93 cases of elderly patients with Alzheimer's disease in Taizhou First People's Hospital from June 2017 to October 2019 were selected as the observation group. All patients were grouped according to the ADAS-Cog table: 53 cases were mild (ADAS-Cog score < 20 points), and 40 cases were moderate to severe (ADAS-Cog score ≥ 20 points). In addition, 50 normal elderly people who underwent health examinations in our hospital during the same period were selected as the control group. The expression of plasma Aβ1-40 and inflammatory indicators [interleukin 1β (IL-1β), IL-6, tumour necrosis factor-α (TNF-α)] were detected by enzyme-linked immunosorbent assay, and the expression of blood lipids [triacylglycerol (TG), high-density lipoprotein (HDL), cholesterol (TC), low-density lipoprotein (LDL)] were detected by a fully automatic biochemical analyser.  Results  The expressions of plasma Aβ1-40, IL-1β, IL-6 and TNF-α were higher in the observation group than in the control group [(109.37±8.52) pg/mL vs. (93.48±7.23) pg/mL, (49.53±6.09) pg/mL vs. (30.51±7.46) pg/mL, (170.87±50.71) pg/mL vs. (75.15±45.27) pg/mL, (65.93±5.72) pg/mL vs. (36.70±5.24) pg/mL, all P < 0.05]. No statistically significant difference was observed in the HDL levels between the two groups of patients (all P>0.05). The blood lipid levels of TG, TC and LDL were higher in the observation group than in the control group (all P < 0.05). The levels of plasma Aβ1-40, IL-1β, IL-6 and TNF-α were higher in the moderate to severe group than in the mild group (all P < 0.05). No significant difference were observed in the levels of serum TG, HDL, TC and LDL in the mild and moderate groups (all P>0.05).  Conclusion  The expressions of plasma Aβ1-40, blood lipids and inflammatory factors are closely related to the severity of Alzheimer's disease in the elderly, which can provide reference for the clinical evaluation of the progress of Alzheimer's disease in the elderly.

     

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