Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2041-2044
LAN wei, QIN Shu-guang, LIU Jian-fang, GUO Jing-yi, LYU Min-qing. Effect of double plasma adsorption of plasma on acute paraquat poisoning[J]. Chinese Journal of General Practice, 2021, 19(12): 2041-2044. doi: 10.16766/j.cnki.issn.1674-4152.002231
Citation: LAN wei, QIN Shu-guang, LIU Jian-fang, GUO Jing-yi, LYU Min-qing. Effect of double plasma adsorption of plasma on acute paraquat poisoning[J]. Chinese Journal of General Practice, 2021, 19(12): 2041-2044. doi: 10.16766/j.cnki.issn.1674-4152.002231
shu

Effect of double plasma adsorption of plasma on acute paraquat poisoning

doi: 10.16766/j.cnki.issn.1674-4152.002231
  • 1.

    Department of Nephrology, Guangzhou Twelfth People's Hospital, Guangzhou, Guangdong 510620, China

Funds:

 B2021147

  • Received Date: 2021-03-21
    Available Online: 2022-03-02
    Abstract
  •   Objective  To investigate the effect of dual plasma molecular adsorption system (DPMAS) on patients with paraquat poisoning.  Methods  A total of 79 patients with acute paraquat poisoning, who were admitted to the Twelfth People's Hospital of Guangzhou from March 2017 to August 2019, were selected and divided into the control group (32 cases) and observation group (47 cases) based on differences in treatment. The control group underwent conventional treatment, and the observation group underwent conventional treatment combined with DPMAS treatment. The clearance rate, survival rate and survival time and the levels of paraquat, bilirubin and malondialdehyde in the peripheral blood were compared between the two groups. In addition, the liver and kidney function and myocardial enzyme index levels of the patients before and after treatment were compared.  Results  The clearance rate of paraquat in the observation group was (68.45±2.56)%, which was higher than that in the control group [(52.60±2.04)%, P < 0.05], the serum paraquat level in the observation group [T2 (4.70±1.95) mg/L, T3 (3.19±1.82) mg/L and T4 (0.83±0.78) mg/L] were lower than that in the control group [T2 (6.92±1.37) mg/L, T3 (5.57±0.09) mg/L and T4 (3.52±1.22) mg/L], respectively (all P < 0.05). In addition, the survival rate of the observation group was 78.72%, and the survival time was (21.69±6.05) days, which were better than the control group [28.13%, (10.12±3.85) days, all P < 0.05]. After treatment, the concentrations of bilirubin and malondialdehyde in the peripheral blood of the two groups were significantly reduced, of which the observation group was lower than the control group (all P < 0.05). The alanine aminotransferase, aspartate aminotransferase, creatine kinase isoenzymes-MB and serum creatinine levels of the two groups and the other indicators after treatment were lower than those before treatment (all P < 0.05), and the degree of reduction in the observation group was higher than that of the control group (all P < 0.05).  Conclusion  The DPMAS can rapidly remove the paraquat content in the blood of patients with acute paraquat poisoning, educe the levels of bilirubin and malondialdehyde, reduce inflammation and myocardial damage, improve immunity, liver and kidney function, prolong the survival time of patients and improve survival rate.

     

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