Volume 19 Issue 12
Dec.  2021
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HUANG Yi-bo, WANG Guo-ping, WANG Yi, MO Wen-kui. Correlation analysis of SFRP1, SFRP2 and SDC-2 methylation and pathological features in patients with gastric cancer[J]. Chinese Journal of General Practice, 2021, 19(12): 2008-2011. doi: 10.16766/j.cnki.issn.1674-4152.002222
Citation: HUANG Yi-bo, WANG Guo-ping, WANG Yi, MO Wen-kui. Correlation analysis of SFRP1, SFRP2 and SDC-2 methylation and pathological features in patients with gastric cancer[J]. Chinese Journal of General Practice, 2021, 19(12): 2008-2011. doi: 10.16766/j.cnki.issn.1674-4152.002222
shu

Correlation analysis of SFRP1, SFRP2 and SDC-2 methylation and pathological features in patients with gastric cancer

doi: 10.16766/j.cnki.issn.1674-4152.002222

  • Department of General Surgery, the Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang 310005, China

Funds:

 2017KY517

  • Received Date: 2020-05-19
    Available Online: 2022-03-02
    Abstract
  •   Objective  To analyse the correlation between secreted frizzled related protein 1(SFRP1), SFRP2 and SDC-2 gene methylation and clinicopathological characteristics of gastric cancer.  Methods  A total of 100 patients who underwent radical gastric cancer surgery from May 2017 to April 2019 in the Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine were collected, and the methylation status of SFRP1, SFRP2 and SDC-2 genes in gastric cancer tissues was detected. The difference of the above-mentioned gene methylation rate in gastric cancer tissues with different clinicopathological characteristics was analysed.  Results  The methylation rates of SDC-2, SFRP1 and SFRP2 genes, tumor diameter, depth of invasion, lymph node metastasis and differentiation were different in cancer tissues (all P < 0.05). Multivariate logistic regression analysis showed that SDC-2 methylation (OR=0.384) was an independent protective factor affecting cancer size (P < 0.05). SFRP2 methylation (OR=5.991) was an independent risk factor affecting the depth of tumour invasion, whilst SDC-2 methylation (OR=0.171) was an independent protective factor affecting the depth of tumour invasion (all P < 0.05). SFRP1 methylation (OR=4.614) was an independent risk factor affecting tumour lymph node metastasis, whilst SDC-2 methylation (OR=0.345) was an independent protective factor inhibiting tumour lymph node metastasis (all P < 0.05). SFRP1 methylation (OR=11.667) and SFRP2 methylation (OR=23.333) were independent risk factors affecting tumour differentiation (all P < 0.05).  Conclusion  The methylation status of SFRP1, SFRP2 and SDC-2 genes is highly correlated with the clinicopathological characteristics of gastric cancer patients. The methylation of SFRP1 and SFRP2 genes may be related factors that promote tumour growth, migration and poor differentiation.

     

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