Volume 19 Issue 10
Oct.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(10): 1637-1641
WANG Tong, WANG Feng-yun, ZHANG Qian-qian, WANG Pei-yan, TANG Jian-min. Value of fibrinogen-to-albumin ratio in predicting the formation and prognosis of collateral circulation in patients with chronic complete coronary artery occlusion[J]. Chinese Journal of General Practice, 2021, 19(10): 1637-1641. doi: 10.16766/j.cnki.issn.1674-4152.002130
Citation: WANG Tong, WANG Feng-yun, ZHANG Qian-qian, WANG Pei-yan, TANG Jian-min. Value of fibrinogen-to-albumin ratio in predicting the formation and prognosis of collateral circulation in patients with chronic complete coronary artery occlusion[J]. Chinese Journal of General Practice, 2021, 19(10): 1637-1641. doi: 10.16766/j.cnki.issn.1674-4152.002130
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Value of fibrinogen-to-albumin ratio in predicting the formation and prognosis of collateral circulation in patients with chronic complete coronary artery occlusion

doi: 10.16766/j.cnki.issn.1674-4152.002130

  • Department of Cardiology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, China

Funds:

 162102310516

  • Received Date: 2020-12-17
    Available Online: 2022-02-15
    Abstract
  •   Objective  To explore the value of fibrinogen-to-albumin ratio (FAR) in predicting the formation and prognosis of collateral circulation in patients with chronic total occlusion (CTO).  Methods  From October 2017 to April 2019, 126 coronary heart disease patients with CTO in an at least one major coronary artery were selected for percutaneous coronary intervention (PCI) in the Second Affiliated Hospital of Zhengzhou University. According to the Cohen-Rentrop method, patients with CTO were divided into two groups: poor collateral circulation group (n=72) and good collateral circulation group (n=54). Multivariate logistic regression screening was used to evaluate the influencing factors of collateral circulation formation in patients with CTO. The receiver operating characteristic (ROC) curve was used to evaluate the value of FAR in predicting collateral circulation formation in CTO patients. The incidence of major adverse cardiovascular events (MACEs) within one year of follow-up was used to evaluate the prognosis of patients.  Results  The levels of FAR and high-sensitivity C-reactive protein in patients with good collateral circulation were lower than those in patients with poor collateral circulation (P < 0.001). Multivariate logistic regression analysis showed an independent negative correlation between FAR, high-sensitivity C-reactive protein and good collateral circulation in patients with CTO. The ROC curve showed that the area under the curve of admission FAR level to predict the formation of collateral circulation in CTO patients was 0.832 (95% CI: 0.755-0.893, P < 0.001), the diagnostic threshold was 9.62, the sensitivity was 85.19%, and the specificity was 77.78%.  Conclusion  The level of FAR on admission has a certain predictive value for the formation of collateral circulation in patients with CTO. Patients with lower FAR have better collateral circulation formation, lower incidence of MACEs and better prognosis.

     

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