Volume 19 Issue 9
Sep.  2021
Turn off MathJax
Article Contents
JIN Jing, ZHOU Yi-nong, JIANG Ming, ZHENG Jie, ZHAN Lin-sen. Effects of goal-directed colloid infusion on short-term recovery and immune function during colorectal cancer resection[J]. Chinese Journal of General Practice, 2021, 19(9): 1593-1596. doi: 10.16766/j.cnki.issn.1674-4152.002119
Citation: JIN Jing, ZHOU Yi-nong, JIANG Ming, ZHENG Jie, ZHAN Lin-sen. Effects of goal-directed colloid infusion on short-term recovery and immune function during colorectal cancer resection[J]. Chinese Journal of General Practice, 2021, 19(9): 1593-1596. doi: 10.16766/j.cnki.issn.1674-4152.002119

Effects of goal-directed colloid infusion on short-term recovery and immune function during colorectal cancer resection

doi: 10.16766/j.cnki.issn.1674-4152.002119
Funds:

 2019RC306

  • Received Date: 2020-11-11
    Available Online: 2022-02-15
  •   Objective  To analyse the clinical value of goal-directed infusion of colloidal fluid in promoting short-term recovery and improving immune function in patients undergoing colorectal cancer resection.  Methods  The clinical data of 164 colorectal cancer resection patients who underwent colorectal cancer resection in our hospital from January 2019 to August 2020 were retrospectively analysed. According to whether colloidal fluid was injected after intraoperative general anaesthesia induction, the observation group (86 cases) received colloidal fluid peripherally, whilst the control group (78 cases) received crystal fluid peripherally. The perioperative information, central venous oxygen saturation (ScvO2), lactate (Lac) and blood glucose (Glu) concentrations at different time points, the occurrence of surgical complications, and the level of humoral immunity in both groups were compared.  Results  No statistically significant differences were observed in both groups in terms of operation time, intraoperative blood loss, fluid replacement and urine volume (all P>0.05). The first exhaust time, defecation time, half flow diet time and hospital stay in the observation group were shorter than those in the control group (all P < 0.05). At the end of surgery, the concentrations of ScvO2, Lac and Glu in both groups were not statistically significant (all P>0.05). The incidence of nausea and vomiting in the observation group was 8.14%, which was lower than that in the control group (20.51%), and the difference was statistically significant (P < 0.05). Postoperative humoral immune indexes in both groups were lower than those before surgery. Three days after surgery, the serum IgG and C4 levels in the observation group were higher than those in the control group, and the difference was statistically significant (P < 0.05).  Conclusion  Goal-directed infusion of colloidal fluid can shorten the length of hospital stay, reduce nausea and vomiting and protect the immune function of patients after colorectal cancer resection, which deserves further research and application.

     

  • loading
  • [1]
    中国临床肿瘤学会, 结直肠癌专家委员会. 可切除的进展期结直肠癌围手术期治疗专家共识(2019)[J]. 中华胃肠外科杂志, 2019, 22(8): 701-710.
    [2]
    JOOSTEN A, DELAPORTE A, ICKX B, et al. Crystalloid versus colloid for intraoperative goal-directed fluid therapy using a closed-loop system: A randomized, double-blinded, controlled trial in major abdominal surgery[J]. Anesthesiology, 2018, 128(1): 55-66. doi: 10.1097/ALN.0000000000001936
    [3]
    丁琳, 高志峰, 王晓宇, 等. 目标导向液体治疗中晶体液和胶体液对血管内皮多糖包被的影响[J]. 临床麻醉学杂志, 2018, 34(9): 873-877. https://www.cnki.com.cn/Article/CJFDTOTAL-LCMZ201809013.htm
    [4]
    KHAN N, REDING J, GILBERT M, et al. Do multiple isolated vertebral thoracolumbar transverse process fractures increase the risk of ligamentous injury and surgical intervention in the setting of trauma[J]. Open J Mod Nurse, 2018, 8(1): 77-83. http://www.cqvip.com/QK/72780X/20181/HS727802018001006.html
    [5]
    WANG Z, DO CARMO J M, ABERDEIN N, et al. Synergistic interaction of hypertension and diabetes in promoting kidney injury and the role of endoplasmic reticulum stress[J]. Hypertension, 2017, 69(5): 879-891. doi: 10.1161/HYPERTENSIONAHA.116.08560
    [6]
    吴雅娟, 鲁晓梅, 任建光. 肝脏手术经不同目标导向液体治疗策略对组织灌注及患者恢复的影响分析[J]. 中国医师进修杂志, 2018, 41(2): 128-132. doi: 10.3760/cma.j.issn.1673-4904.2018.02.009
    [7]
    孟改革, 方卫平, 张雷, 等. 目标导向液体治疗下晶体液与胶体液输注对肝切除术患者组织灌注和术后恢复的影响[J]. 临床麻醉学杂志, 2017, 33(6): 557-561. doi: 10.3969/j.issn.1004-5805.2017.06.009
    [8]
    CVETKOVIC A, KALEZIC N, MILICIC B, et al. Hemodynamic stability achievement by application of goal directed fluid therapy with different infusion solutions in colorectal surgery[J]. J BUON, 2018, 23(2): 329-339. http://www.jbuon.com/pdfs/23-2/23-2-329-339.pdf
    [9]
    刘峰, 何宋兵, 郭兴坡, 等. 腹腔镜手术与传统开腹手术对老年结肠癌患者术后生理应激及凝血、认知功能和炎症因子的影响[J]. 中国老年学杂志, 2018, 38(2): 342-344. doi: 10.3969/j.issn.1005-9202.2018.02.036
    [10]
    KURE T, SAKAI H. Transmembrane difference in colloid osmotic pressure affects the lipid membrane fluidity of liposomes encapsulating a concentrated protein solution[J]. Langmuir, 2017, 33(6): 1533-1540. doi: 10.1021/acs.langmuir.6b04643
    [11]
    谷洁, 高志峰, 王晓宇, 等. 基于不同目标的目标导向液体治疗对高危腹部手术患者围术期血管内皮多糖包被的影响: 前瞻性随机对照研究[J]. 中华麻醉学杂志, 2018, 38(6): 707-711. doi: 10.3760/cma.j.issn.0254-1416.2018.06.018
    [12]
    单剑锋, 俞耀军. 腹腔镜下结直肠癌术后感染并发症的特点及危险因素分析[J]. 中华全科医学, 2017, 15(7): 1153-1155. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201707019.htm
    [13]
    MALLICK-SEARLE T, FILLMAN M. The pathophysiology, incidence, impact, and treatment of opioid-induced nausea and vomiting[J]. J Am Assoc Nurse Pract, 2017, 29(11): 704-710. doi: 10.1002/2327-6924.12532
    [14]
    王翔, 周婷, 方嘉凯, 等. 目标导向液体治疗在胃肠外科ERAS术中容量管理的应用[J]. 广东医学, 2018, 39(9): 1279-1282. doi: 10.3969/j.issn.1001-9448.2018.09.004
    [15]
    赵力, 彭静, 周敏, 等. 全麻复合腰硬联合麻醉对低位直肠癌患者腹腔镜手术后时间及血清免疫球蛋白、C3水平变化的影响[J]. 广东医学, 2019, 40(4): 526-530. https://www.cnki.com.cn/Article/CJFDTOTAL-GAYX201904014.htm
    [16]
    WOLTHUIS A M, BISLENGHI G, LAMBERCHT M, et al. Preoperative risk factors for prolonged postoperative ileus after colorectal resection[J]. Int J Colorectal Dis, 2017, 32(6): 883-890. doi: 10.1007/s00384-017-2824-6
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Article Metrics

    Article views (195) PDF downloads(2) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return