Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1518-1521
WANG Ji-sheng, WU Li-cun, WU Hui, WANG Lei, ZHOU Rui. Clinical effect and inflammatory factor analysis of nebulised inhalation of acetylcysteine solution combined with budesonide in the treatment of infant pneumonia[J]. Chinese Journal of General Practice, 2021, 19(9): 1518-1521. doi: 10.16766/j.cnki.issn.1674-4152.002101
Citation: WANG Ji-sheng, WU Li-cun, WU Hui, WANG Lei, ZHOU Rui. Clinical effect and inflammatory factor analysis of nebulised inhalation of acetylcysteine solution combined with budesonide in the treatment of infant pneumonia[J]. Chinese Journal of General Practice, 2021, 19(9): 1518-1521. doi: 10.16766/j.cnki.issn.1674-4152.002101
shu

Clinical effect and inflammatory factor analysis of nebulised inhalation of acetylcysteine solution combined with budesonide in the treatment of infant pneumonia

doi: 10.16766/j.cnki.issn.1674-4152.002101
  • 1.

    Department of Pediatrics, the People's Hospital of Xiao County and Xiao County Hospital of the First Affiliated of Bengbu Medical College, Suzhou, Anhui 235200, China

Funds:

 KJ2019A0342

 W2016EWAH06

  • Received Date: 2021-01-15
    Available Online: 2022-02-15
    Abstract
  •   Objective  To explore the clinical effect of nebulised inhalation of acetylcysteine solution combined with budesonide in the treatment of infant pneumonia and its effect on inflammatory factors.   Methods  Sixty-six infants and young children with pneumonia admitted to the hospital from July 2019 to August 2020 were selected. They were divided into the control group (n=31) and observation group (n=35) according to the drug regimen. The control group was treated with basic symptomatic treatment and 2 mL of budesonide twice a day for 7 days. On the basis of treatment of the control group, the observation group was treated with combined atomisation inhalation of 0.3 g acetylcysteine solution twice a day for 7 days. The clinical efficacy, disappearance time of clinical symptoms and occurrence of adverse reactions in both groups were compared, and the differences of serum inflammatory factors and lung function indicators in both groups before and after treatment were compared.   Results  The total effective rate (88.57%) of the observation group was higher than that of the control group (64.52%, χ2=5.147, P=0.020). The disappearance time of clinical symptoms and the temperature recovery time in the observation group were obviously shorter than those in the control group (all P < 0.05). The incidence of adverse reactions in both groups showed no significant difference (P>0.05). Serum interferon-γ, interleukin-6, interleukin-2, procalcitonin and C-reactive protein in both groups were significantly lower after treatment than before treatment, but the levels of inflammatory factors in the observation group were remarkably lower than those in the control group (all P < 0.05). The lung function indexes of both groups were significantly improved after treatment compared with those before treatment, and the improvement was more obvious in the observation group than in the control group (all P < 0.05).   Conclusion  Nebulised inhalation of acetylcysteine solution combined with budesonide in the treatment of infant pneumonia has significant clinical efficacy. It can significantly shorten the disappearance time of various symptoms, reduce serum inflammation factors and help restore lung function. Moreover, it is relatively safe and is worthy of clinical promotion.

     

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