Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1507-1509,1607
HU Zhi-min, ZHANG Yong, QIAN Chao-xia. Clinical observation of high-intensity non-invasive positive pressure ventilation in the treatment of AECOPD patients complicated with type Ⅱ respiratory failure[J]. Chinese Journal of General Practice, 2021, 19(9): 1507-1509,1607. doi: 10.16766/j.cnki.issn.1674-4152.002098
Citation: HU Zhi-min, ZHANG Yong, QIAN Chao-xia. Clinical observation of high-intensity non-invasive positive pressure ventilation in the treatment of AECOPD patients complicated with type Ⅱ respiratory failure[J]. Chinese Journal of General Practice, 2021, 19(9): 1507-1509,1607. doi: 10.16766/j.cnki.issn.1674-4152.002098
shu

Clinical observation of high-intensity non-invasive positive pressure ventilation in the treatment of AECOPD patients complicated with type Ⅱ respiratory failure

doi: 10.16766/j.cnki.issn.1674-4152.002098
  • 1.

    Department of Respiratory and Critical Care Medicine, Bengbu Third People's Hospital Affiliated to Bengbu Medical College, Bengbu, Anhui 233000, China

Funds:

 1804h08020287

  • Received Date: 2020-12-25
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the effect of high-intensity and conventional pressure non-invasive positive pressure ventilation in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with type Ⅱ respiratory failure.   Methods  A total of 72 patients with AECOPD and type Ⅱ respiratory failure in the Respiratory Department of Bengbu Third Hospital from October 2018 to January 2020 were included. They were divided into the high-intensity group (36 cases) and conventional pressure group (36 cases) by simple random method. The inspiratory pressure was set to (24.7±1.8) cm H2O and (16.1±1.2) cm H2O, respectively. The pH, PaCO2, PaO2 between the two groups and within 2, 6, 24, 48, 72 h after treatment, adverse effects of non-invasive ventilation, tracheal intubation rate and fatality rate, hospitalisation days, re-admission rate 28 days after discharge and 6-minute walking distance were compared.   Results  The differences in pH, PaO2 and PaCO2 between both groups before treatment were not statistically significant (all P>0.05). The differences in pH and adverse reactions after treatment were not statistically significant (all P>0.05). The differences in PaO2 and PaCO2 were statistically significant (all P>0.05). The tracheal intubation rate was 8.33% (3/36) and 13.89% (5/36). The fatality rate was 2.78% (1/36) and 8.33% (3/36); the difference were not statistically significant (all P>0.05). The number of hospitalisation days were (10.0±1.7) and (13.2±1.9) days. The difference was statistically significant (P < 0.05). No significant difference was observed in the readmission rate and 6-min walking distance of patients 28 days after discharge (both P>0.05).   Conclusion  The application of high-intensity non-invasive positive pressure ventilation can improve PaO2 and PaCO2 in patients with AECOPD combined with type Ⅱ respiratory failure more quickly, without a significant increase in adverse reactions. Moreover and shorten the hospital stay.

     

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    • References(22)
  • [1]
    崔亚楠, 陈平, 陈燕. 2018年版慢性阻塞性肺疾病全球倡议诊断及处理和预防策略解读[J]. 中华结核和呼吸杂志, 2018, 41(3): 236-239. doi: 10.3760/cma.j.issn.1001-0939.2018.03.019
    [2]
    ERGAN B, OCZKOWSKI S, ROCHWERG B, et al. European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD[J]. Eur Respir J, 2019, 54(3): 1901003. doi: 10.1183/13993003.01003-2019
    [3]
    COLEMAN J M, WOLFE L F, KALHAN R. Noninvasive ventilation in chronic obstructive pulmonary disease[J]. Ann Am Thorac Soc, 2019, 16(9): 1091-1098. doi: 10.1513/AnnalsATS.201810-657CME
    [4]
    LUO Z, WU C, LI Q, et al. High-intensity versus low-intensity noninvasive positive pressure ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease (HAPPEN): Study protocol for a multicenter randomized controlled trial[J]. Trials, 2018, 19(1): 645. doi: 10.1186/s13063-018-2991-y
    [5]
    翟武杰. 无创正压机械通气不同通气模式治疗COPD急性加重期呼吸衰竭的疗效对比[J]. 医药论坛杂志, 2020, 41(1): 99-101. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202001031.htm
    [6]
    DUIVERMAN M L. Noninvasive ventilation in stable hypercapnic COPD: What is the evidence?[J]. ERJ Open Res, 2018, 4(2). DOI: 10.1183/23120541.00012-2018.
    [7]
    DUIVERMAN M L, VONK J M, BLADDER G, et al. Home initiation of chronic non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure: A randomised controlled trial[J]. Thorax, 2020, 75(3): 244-252. doi: 10.1136/thoraxjnl-2019-213303
    [8]
    吴晓虞, 施晓倩, 何六涛, 等. 高压力无创通气对COPD合并严重Ⅱ型呼吸衰竭的临床疗效[J]. 浙江医学教育, 2018, 17(3): 49-51. doi: 10.3969/j.issn.1672-0024.2018.03.017
    [9]
    RHEE C K, CHAU N Q, YUNUS F, et al. Management of COPD in Asia: A position statement of the Asian Pacific Society of Respirology[J]. Respirology, 2019, 24(10): 1018-1025. doi: 10.1111/resp.13633
    [10]
    ANEES UR REHMAN, AHMAD HASSALI M A, MUHAMMAD S A, et al. The economic burden of chronic obstructive pulmonary disease (COPD) in the USA, Europe, and Asia: Results from a systematic review of the literature[J]. Expert Rev Pharmacoecon Outcomes Res, 2020, 20(6): 661-672. doi: 10.1080/14737167.2020.1678385
    [11]
    陈宇清, 袁越阳, 张海, 等. 无创双水平正压通气状态下呼吸力学特性的测算分析研究[J]. 中国呼吸与危重监护杂志, 2019, 18(6): 537-542. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGHW201906009.htm
    [12]
    张知远, 金海珍, 余欣颐. 慢阻肺急性加重期患者外周血T细胞中PD-1/PD-L1的表达及意义[J]. 中华全科医学, 2020, 18(3): 419-422, 426. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202003022.htm
    [13]
    SCHWARZ S B, MAGNET F S, WINDISCH W. Why High-Intensity NPPV is Favourable to Low-Intensity NPPV: Clinical and Physiological Reasons[J]. COPD, 2017, 14(4): 389-395. doi: 10.1080/15412555.2017.1318843
    [14]
    张利红. 联合检测NLR和NT-pro BNP对慢性阻塞性肺疾病急性加重期呼吸衰竭发作的预测价值[J]. 国际检验医学杂志, 2020, 41(17): 2158-2161. doi: 10.3969/j.issn.1673-4130.2020.17.025
    [15]
    张亮. 沙丁胺醇与无创呼吸机联合治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床研究[J]. 现代医药卫生, 2019, 35(18): 2880-2882. doi: 10.3969/j.issn.1009-5519.2019.18.037
    [16]
    刘魁, 钱会, 韩可兴, 等. 135例COPD急性加重患者营养状况及其与急性加重的关系分析[J]. 中华全科医学, 2020, 18(8): 1313-1315, 1347. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202008020.htm
    [17]
    杜锦龙. 不同吸入氧浓度对AECOPD合并Ⅱ型呼吸衰竭无创通气下安全性及有效性评价[J]. 医药论坛杂志, 2021, 42(1): 62-65. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202101017.htm
    [18]
    邱志红, 刘保萍, 张换春, 等. 高压力无创正压通气治疗慢性阻塞性肺疾病稳定期伴呼吸衰竭的疗效观察[J]. 广西医科大学学报, 2018, 35(7): 936-940. https://www.cnki.com.cn/Article/CJFDTOTAL-GXYD201807011.htm
    [19]
    雷瑞新. COPD急性加重期合并Ⅱ型呼吸衰竭应用无创呼吸机治疗的疗效及临床症状改善分析[J]. 医药论坛杂志, 2020, 41(7): 114-116. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202007029.htm
    [20]
    DUIVERMAN M L, MAAGH P, MAGNET F S, et al. Impact of High-Intensity-NIV on the heart in stable COPD: A randomised cross-over pilot study[J]. Respir Res, 2017, 18(1): 76. doi: 10.1186/s12931-017-0542-9
    [21]
    VAN DER LEEST S, DUIVERMAN M L. High-intensity non-invasive ventilation in stable hypercapnic COPD: Evidence of efficacy and practical advice[J]. Respirology, 2019, 24(4): 318-328. doi: 10.1111/resp.13450
    [22]
    张慧霞, 李准, 张博昱. NIPPV治疗AECOPD合并Ⅱ型呼吸衰竭的临床疗效及安全性分析[J]. 医药论坛杂志, 2019, 40(5): 121-123. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX201905046.htm
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