Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1463-1465,1603
ZOU Yu-qiong, ZHANG Ying-ying, LI Ya-song. Study on the clinical significance of bone metabolism types in young adult patients with ankylosing spondylitis[J]. Chinese Journal of General Practice, 2021, 19(9): 1463-1465,1603. doi: 10.16766/j.cnki.issn.1674-4152.002086
Citation: ZOU Yu-qiong, ZHANG Ying-ying, LI Ya-song. Study on the clinical significance of bone metabolism types in young adult patients with ankylosing spondylitis[J]. Chinese Journal of General Practice, 2021, 19(9): 1463-1465,1603. doi: 10.16766/j.cnki.issn.1674-4152.002086
shu

Study on the clinical significance of bone metabolism types in young adult patients with ankylosing spondylitis

doi: 10.16766/j.cnki.issn.1674-4152.002086

  • Department of Rheumatology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China

Funds:

 2018ZB009

 2016ZZ006

  • Received Date: 2020-12-18
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the relationship between bone metabolism and bone mineral density in young adults with active ankylosing spondylitis (AS) and to provide a basis for the prevention and treatment of bone mineral density decline in these patients.   Methods  A total of 103 patients with AS who were treated in our hospital from February 2015 to November 2020 were enrolled in the study. The correlation between different bone metabolism types and bone mineral density was analysed.   Results  Forty-nine patients had normal BMD, and 54 patients had low BMD. In the low BMD group, the mean values of type I collagen cross-linked C-telopeptide β-collagen specific sequence (β-CTX), osteocalcin (OC) and N-terminal propeptide of type I precollagen (P1NP) were significantly higher than those in the normal BMD group (P < 0.001). The low BMD group was divided into low to moderate and high conversion groups. The T value of femoral neck BMD in the high conversion group was -1.56±0.82, which was significantly lower than that in the low to medium conversion group (-1.01±0.92, P=0.029). However, no significant difference was found in T value of lumbar BMD between the two groups (P=0.080). In the low to medium conversion group, the BMD of femoral neck [(0.92±0.09) g/cm2] after treatment was significantly improved compared with that before treatment [(0.89±0.08) g/cm2, P=0.022]. However, in the high conversion group, no significant difference in BMD of femoral neck was found after the treatment (P=0.080).   Conclusion  The serum levels of β-CTX, OC and P1NP are significantly increased in young adult patients with decreased bone mineral density, showing high loss of bone turnover high conversion bone loss. Patients with low to moderate conversion of bone mineral density reduction can be effectively treated through active basic disease inflammation control. However, more effective treatments should be explored for patients with high conversion of bone mineral density reduction.

     

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