Volume 19 Issue 8
Aug.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(8): 1398-1402
WU Lian-peng, HE Gui-qing, HU Xing-zhong, PAN Yong, TANG Shao-hua. Analysis of clinical characteristics and risk factors of death in 51 AIDS patients with disseminated Talaromycosis marneffei in Wenzhou[J]. Chinese Journal of General Practice, 2021, 19(8): 1398-1402. doi: 10.16766/j.cnki.issn.1674-4152.002070
Citation: WU Lian-peng, HE Gui-qing, HU Xing-zhong, PAN Yong, TANG Shao-hua. Analysis of clinical characteristics and risk factors of death in 51 AIDS patients with disseminated Talaromycosis marneffei in Wenzhou[J]. Chinese Journal of General Practice, 2021, 19(8): 1398-1402. doi: 10.16766/j.cnki.issn.1674-4152.002070
shu

Analysis of clinical characteristics and risk factors of death in 51 AIDS patients with disseminated Talaromycosis marneffei in Wenzhou

doi: 10.16766/j.cnki.issn.1674-4152.002070
  • 1.

    The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 2017C33215

  • Received Date: 2020-10-10
    Available Online: 2022-02-16
    Abstract
  •   Objective  To understand the clinical characteristics of AIDS patients with disseminated Talaromycosis marneffei in Wenzhou, and to statistically analyze the risk factors of death, so as to provide a basis for clinical diagnosis, treatment and reduction of mortality of patients with these diseases in this area.  Methods  The medical records of 51 AIDS patients with Talaromycosis marneffei treated in Wenzhou Central Hospital from January 2016 to May 2020 were collected. The epidemiological characteristics, clinical manifestations, laboratory and imaging examination results and treatment outcome of the patients were analyzed. According to the treatment outcome, the patients were divided into improvement group (42 cases) and death group (9 cases), and the risk factors of death were compared and analyzed.  Results  From 2016 to 2020, the number of AIDS patients with disseminated Talaromycosis marneffei in Wenzhou area increased year by year, mainly in young adults (64.71%, 33/51). The most common clinical manifestations were fever and lymph node enlargement. The average number of CD4+ T lymphocytes in patients was 9(5, 19) cells/μL, of which 47 cases were less than 50 cells/μL (92.16%). The positive rates of G test and GM test were 70.00% (28/40) and 75.00% (30/40). 50 patients performed by chest CT examination were abnormal, the fatality rate was 17.65% (9/51). The analysis of influencing factors of death showed that the time from hospitalization to antifungal therapy in the death group was longer than that in the improvement group, and the rate of ART in the death group was significantly lower than that in the improvement group, the difference was statistically significant (P < 0.05).  Conclusion  The incidence of AIDS patients with disseminated Talaromycosis marneffei in Wenzhou is increasing year by year. The CD4+ T lymphocyte count of the patients is often less than 50 cells/μL, and the clinical manifestations are diversified. Timely antifungal therapy and antiretroviral therapy can significantly reduce the mortality of the patients.

     

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