Volume 19 Issue 7
Jul.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(7): 1095-1098
LI Chuan-tao, ZHOU Chi, WANG Zhao-ying, LU Zheng, CUI Pei-yuan. Relationship between preoperative NLR and PLR and clinicopathological characteristics and T stage after laparoscopic radical resection of hilar cholangiocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(7): 1095-1098. doi: 10.16766/j.cnki.issn.1674-4152.001993
Citation: LI Chuan-tao, ZHOU Chi, WANG Zhao-ying, LU Zheng, CUI Pei-yuan. Relationship between preoperative NLR and PLR and clinicopathological characteristics and T stage after laparoscopic radical resection of hilar cholangiocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(7): 1095-1098. doi: 10.16766/j.cnki.issn.1674-4152.001993
shu

Relationship between preoperative NLR and PLR and clinicopathological characteristics and T stage after laparoscopic radical resection of hilar cholangiocarcinoma

doi: 10.16766/j.cnki.issn.1674-4152.001993

  • Department of Hepatobiliary Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2008085MH256

  • Received Date: 2020-11-22
    Available Online: 2022-02-16
    Abstract
  •   Objective  To study the relationship between preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with the clinicopathological characteristics and T staging of hilar cholangiocarcinoma (HC).  Methods  The data of patients with HC were analyzed retrospectively. The receiver operating characteristic (ROC) curve was used to determine the best cut-off values of NLR and PLR. Statistical analysis of preoperative NLR and PLR and HC pathological characteristics and the relationship between T staging and the predictive value of T staging.  Results  The ROC curve was used to determine the best cut-off value: high-NLR group (NLR>4.12, 56 cases), low-NLR group (NLR≤4.12, 44 cases), high-PLR group (>184.56, 48 cases) and low-PLR group (≤184.56, 52 cases). Univariate analysis showed that preoperative NLR was correlated with tumour location and T stage (all P < 0.05) and had no correlation with gender, age, degree of differentiation and tumour size (all P > 0.05). Preoperative PLR was correlated with T stage, tumour size and lymph node metastasis (all P < 0.05) and had no correlation with gender, age, degree of differentiation and tumour location (all P > 0.05). Multivariate analysis showed that preoperative NLR was associated with T staging (OR=2.999, P=0.026) and tumour location (OR=0.346, P=0.032). Preoperative PLR was related to T stage (OR=3.635, P=0.007) and tumour size (OR=1.728, P=0.031), but not to lymph node metastasis (P > 0.05). The ROC curve areas of NLR and PLR before surgery were 0.811 and 0.794, respectively, which have predictive value for T staging.  Conclusion  Preoperative NLR and PLR are simple and practical detection indicators that can be used to evaluate the pathological characteristics of HC before surgery and have predictive value for T staging.

     

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