Volume 19 Issue 6
Jun.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 1001-1007
QIN Xi-ru, ZHANG Li-zhi. Mechanisms of Osteoarthritis Pain[J]. Chinese Journal of General Practice, 2021, 19(6): 1001-1007. doi: 10.16766/j.cnki.issn.1674-4152.001971
Citation: QIN Xi-ru, ZHANG Li-zhi. Mechanisms of Osteoarthritis Pain[J]. Chinese Journal of General Practice, 2021, 19(6): 1001-1007. doi: 10.16766/j.cnki.issn.1674-4152.001971
shu

Mechanisms of Osteoarthritis Pain

doi: 10.16766/j.cnki.issn.1674-4152.001971
  • 1.

    Department of General Practice, Yangpu Hospital Affiliated to Tongji University, Shanghai 200090, China

Funds:

 81572218

 13ZR1439100

 20124303

  • Received Date: 2020-09-05
    Available Online: 2022-02-16
    Abstract
  • Osteoarthritis (OA) is the most common joint disease, and its incidence is increasing by years. Currently, there is no effective cure, yet OA is one of the most common causes of functional disability in the elderly. The insufficient knowledge of knee OA and subsequent delayed prevention and treatment of knee OA are the important reasons leading to the increasing morbidity. In clinic, pain is one of the earliest signs in the early stages of OA. Pain is also the main symptom of OA and is one of the most important criteria for diagnosis. Owing to the frequent neglect of early OA pain and insufficient understanding of the cause and mechanism of OA pain, getting satisfactory treatment effect is often difficult. As a result, the incidence of complaints of patients is increasing. Subsequently, progress of the lesions is continuing, which are closely related to the joint disability of patients and eventually joint replacement. Therefore, the causes, characteristics, conduction and perception of pain; the relationship between pain occurrence and development of osteoarthritis and the pathophysiological mechanism of OA pain must be identified. Studies show that OA-related pain has a complex pathophysiologic mechanism, and it is not only a kind of joint injurious pain depending on abnormal stress and biological interplay but also closely related to local inflammation, peripheral and central neuropathy and regulated by a variety of factors (e.g. spirit, gene, weather, etc). Furthermore, clinical findings emphasize that OA is not a stable and linear condition. Pain experience is independent of structural modifications, and it occurs to varying degrees in a patient- and time-specific manner. Therefore, this review covers studies on the mechanisms of OA pain. The review is expected to be helpful for physicians to find the cause of poor curative effect and improve them, for researchers to make transformation from basic study to clinical work, for patients to acquire an optimal management relieving OA-related pain in the future.

     

    • FullText(HTML)
  • loading
    • References(42)
  • [1]
    VAN DER HEIJDEN R A, OEI E H, BRON E E, et al. No difference on quantitative magnetic resonance imaging in patellofemoral cartilage composition between patients with patellofemoral pain and healthy controls[J]. Am J Sports Med, 2016, 44(5): 1172-1178. doi: 10.1177/0363546516632507
    [2]
    OKWERA A, MAY S. Views of general practitioners toward physiotherapy management of osteoarthritis-a qualitative study[J]. Physiother Theory Pract, 2019, 35(10): 940-946. doi: 10.1080/09593985.2018.1459987
    [3]
    MACKOWIAK J, JONES J T, DASA V. A comparison of 4-year total medical care costs, adverse outcomes, and opioid/prescription analgesic use for 3 knee osteoarthritis pain treatments: Intra-articular hyaluronic acid, intra-articular corticosteroids, and knee arthroplasty[J]. Semin Arthritis Rheum, 2020, 50(6): 1525-1534. doi: 10.1016/j.semarthrit.2020.01.003
    [4]
    KULKARNI K, KARSSIENS T, KUMAR V, et al. Obesity and osteoarthritis[J]. Maturitas, 2016, 89: 22-28. doi: 10.1016/j.maturitas.2016.04.006
    [5]
    TEIRLINCK C H, SONNEVELD D S, BIERMA-ZEINSTRA S M A, et al. Daily pain measurements and retrospective pain measurements in hip osteoarthritis patients with intermittent pain[J]. Arthritis Care Res (Hoboken), 2019, 71(6): 768-776. doi: 10.1002/acr.23711
    [6]
    FU K, ROBBINS S R, MCDOUGALL J J. Osteoarthritis: the genesis of pain[J]. Rheumatology (Oxford), 2018, 57(suppl_4): iv43-iv50. doi: 10.1093/rheumatology/kex419
    [7]
    DE LOGU F, GEPPETTI P. Ion channel pharmacology for pain modulation[J]. Handb Exp Pharmacol, 2019, 260: 161-186. doi: 10.1007/164_2019_336
    [8]
    O'NEILL T W, FELSON D T Mechanisms of osteoarthritis (OA) pain[J]. Curr Osteoporos Rep, 2018, 16(5): 611-616. doi: 10.1007/s11914-018-0477-1
    [9]
    HE B H, CHRISTIN M, MOUCHBAHANI-CONSTANCE S, et al. Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis[J]. Osteoarthritis Cartilage, 2017, 25(12): 2091-2099. doi: 10.1016/j.joca.2017.08.012
    [10]
    KAWARAI Y, ORITA S, NAKAMURA J, et al. Analgesic effect of duloxetine on an animal model of monosodium iodoacetate-induced hip osteoarthritis[J]. J Orthop Res, 2020, 38(2): 422-430. doi: 10.1002/jor.24480
    [11]
    LACAGNINA M J, WATKINS L R, GRACE P M. Toll-like receptors and their role in persistent pain[J]. Pharmacol Ther, 2018, 184: 145-158. doi: 10.1016/j.pharmthera.2017.10.006
    [12]
    KALAITZOGLOU E, GRIFFIN T M, HUMPHREY M B. Innate immune responses and osteoarthritis[J]. Curr Rheumatol Rep, 2017, 19(8): 45. doi: 10.1007/s11926-017-0672-6
    [13]
    ROSENBERG J H, RAI V, DILISIO M F, et al. Damage-associated molecular patterns in the pathogenesis of osteoarthritis: Potentially novel therapeutic targets[J]. Mol Cell Biochem, 2017, 434(1-2): 171-179. doi: 10.1007/s11010-017-3047-4
    [14]
    NEFLA M, HOLZINGER D, BERENBAUM F, et al. The danger from within: alarmins in arthritis[J]. Nat Rev Rheumatol, 2016, 12(11): 669-683. doi: 10.1038/nrrheum.2016.162
    [15]
    DENK F, BENNETT D L, MCMAHON S B. Nerve growth factor and pain mechanisms[J]. Annu Rev Neurosci, 2017, 40: 307-325. doi: 10.1146/annurev-neuro-072116-031121
    [16]
    NEES T A, ROSSHIRT N, REINER T, et al. Inflammation and osteoarthritis-related pain[J]. Schmerz, 2019, 33(1): 4-12. doi: 10.1007/s00482-018-0346-y
    [17]
    SCHAIBLE H G. Osteoarthritis pain. Recent advances and controversies[J]. Curr Opin Support Palliat Care, 2018, 12(2): 148-153. doi: 10.1097/SPC.0000000000000334
    [18]
    MILLER R E, KIM Y S, TRAN P B, et al. Visualization of peripheral neuron sensitization in a surgical mouse model of osteoarthritis by in vivo calcium imaging[J]. Arthritis Rheumatol, 2018, 70(1): 88-97. doi: 10.1002/art.40342
    [19]
    ZHANG F, LIU Y, ZHANG D, et al. Suppression of KCNQ/M potassium channel in dorsal root ganglia neurons contributes to the development of osteoarthritic pain[J]. Pharmacology, 2019, 103(5-6): 257-262. doi: 10.1159/000496422
    [20]
    TROUVIN A P, PERROT S. Pain in osteoarthritis. Implications for optimal management[J]. Joint Bone Spine, 2018, 85(4): 429-434. doi: 10.1016/j.jbspin.2017.08.002
    [21]
    BARTLEY E J, KING C D, SIBILLE K T, et al. Enhanced pain sensitivity among individuals with symptomatic knee osteoarthritis: Potential sex differences in central sensitization[J]. Arthritis Care Res (Hoboken), 2016, 68(4): 472-480. doi: 10.1002/acr.22712
    [22]
    VINCENT T L. Mechanoflammation in osteoarthritis pathogenesis[J]. Semin Arthritis Rheum, 2019, 49(3S): S36-S38. http://www.sciencedirect.com/science/article/pii/S0049017219306535
    [23]
    CHANG S H, MORI D, KOBAYASHI H, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway[J]. Nat Commun, 2019, 10(1): 1442. doi: 10.1038/s41467-019-09491-5
    [24]
    CHOI W S, LEE G, SONG W H, et al. The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis[J]. Nature, 2019, 566(7743): 254-258. doi: 10.1038/s41586-019-0920-1
    [25]
    WU J, WANG K, XU J, et al. Associations between serum ghrelin and knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee osteoarthritis[J]. Osteoarthritis Cartilage, 2017, 25(9): 1428-1435. doi: 10.1016/j.joca.2017.05.015
    [26]
    LEE S H, KWON J Y, JHUN J, et al. Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis[J]. Immunol Lett, 2018, 203: 6-14. doi: 10.1016/j.imlet.2018.07.003
    [27]
    KLEIN-WIERINGA I R, DE LANGE-BROKAAR B J, YUSUF E, et al. Inflammatory cells in patients with endstage knee osteoarthritis: A comparison between the synovium and the infrapatellar fat pad[J]. J Rheumatol, 2016, 43(4): 771-778. doi: 10.3899/jrheum.151068
    [28]
    LI Y S, LUO W, ZHU S A, et al. T cells in osteoarthritis: Alterations and beyond[J]. Front Immunol, 2017, 8: 356. doi: 10.3389/fimmu.2017.00356/pdf
    [29]
    EYMARD F, CHEVALIER X. Inflammation of the infrapatellar fat pad[J]. Joint Bone Spine, 2016, 83(4): 389-393. doi: 10.1016/j.jbspin.2016.02.016
    [30]
    WANG Q, LEPUS C M, RAGHU H, et al. Ige-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis[J]. Elife, 2019, 8: e39905. http://www.researchgate.net/publication/333090533_IgE-mediated_mast_cell_activation_promotes_inflammation_and_cartilage_destruction_in_osteoarthritis/download
    [31]
    BORBÉLY É, SÁNDOR K, MARKOVICS A, et al. Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees[J]. Inflamm Res, 2016, 65(9): 725-736. doi: 10.1007/s00011-016-0954-x
    [32]
    MULEY M M, REID A R, BOTZ B, et al. Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase-activated receptor-2[J]. Br J Pharmacol, 2016, 173(4): 766-777. doi: 10.1111/bph.13237
    [33]
    曾允富, 卞阳阳, 王溶, 等. 梓醇抑制骨关节炎发病机制的研究[J]. 中华全科医学, 2019, 17(10): 1626-1630, 1651. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201910004.htm
    [34]
    陈亮, 杨晓凌. 骨关节炎患者血清中炎性因子IL-1β、IL-6和COX-2的表达[J]. 中国临床医学, 2016, 23(1): 61-62. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX201601017.htm
    [35]
    WALSH D A. Editorial: Synovitis and pain sensitization[J]. Arthritis Rheumatol, 2016, 68(3): 561-562. doi: 10.1002/art.39487
    [36]
    LEUNG Y Y, HUEBNER J L, HAALAND B, et al. Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain[J]. Osteoarthritis Cartilage, 2017, 25(9): 1420-1427. doi: 10.1016/j.joca.2017.04.001
    [37]
    MILLER R E, TRAN P B, ISHIHARA S, et al. Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis[J]. Osteoarthritis Cartilage, 2020, 28(5): 581-592. doi: 10.1016/j.joca.2020.01.008
    [38]
    施利华, 李恒, 郭潘, 等. miRNA-27a和miRNA-146a在骨性关节炎患者中的诊断意义[J]. 中华全科医学, 2020, 18(3): 412-414, 418. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202003020.htm
    [39]
    李坤, 张育民, 王亚康, 等. 上调microRNA-543表达对大鼠骨关节炎软骨细胞的保护作用[J]. 中国临床医学, 2018, 25(2): 239-243. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX201802015.htm
    [40]
    EDWARDS R R, DWORKIN R H, SULLIVAN M D, et al. The role of psychosocial processes in the development and maintenance of chronic pain[J]. J Pain, 2016, 17(9 Suppl): T70-92.
    [41]
    TURK D C, FILLINGIM R B, OHRBACH R, et al. Assessment of psychosocial and functional impact of chronic pain[J]. J Pain, 2016, 17(9 Suppl): T21-49.
    [42]
    HELMINEN E E, SINIKALLIO S H, VALJAKKA A L, et al. Determinants of pain and functioning in knee osteoarthritis: A one-year prospective study[J]. Clin Rehabil, 2016, 30(9): 890-900. doi: 10.1177/0269215515619660
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (515) PDF downloads(25) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return