Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 871-874
LYU Qing, CHEN Wei-dong, LIU Lei. Multivariate analysis and correlation study of anaemia in patients with maintenance haemodialysis[J]. Chinese Journal of General Practice, 2021, 19(5): 871-874. doi: 10.16766/j.cnki.issn.1674-4152.001938
Citation: LYU Qing, CHEN Wei-dong, LIU Lei. Multivariate analysis and correlation study of anaemia in patients with maintenance haemodialysis[J]. Chinese Journal of General Practice, 2021, 19(5): 871-874. doi: 10.16766/j.cnki.issn.1674-4152.001938
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Multivariate analysis and correlation study of anaemia in patients with maintenance haemodialysis

doi: 10.16766/j.cnki.issn.1674-4152.001938

  • Department of Nephrology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0321

  • Received Date: 2020-10-21
    Available Online: 2022-02-16
    Abstract
  •   Objective   To investigate the multiple aetiologies and correlation of anaemia in patients with maintenance haemodialysis (MHD).   Methods   A cross-sectional investigation was used to analyse the demographic data, dialysis treatment information and laboratory indicators of patients with MHD in three blood purification Centers of Bengbu from October 2019 to June 2020. According to the target haemoglobin level recommended by Kidney Disease: Improving Global Outcomes (KDIGO) guidelines in 2012, 304 patients with MHD were divided into anaemia group and non-anaemia group. Single factor was first used to carry out the analysis for two groups. The single factor with statistical significance was then included in the logistic multiple-factor analysis so as to analyse the risk factors of anaemia in patients with MHD.   Results   The average age of the 304 patients with MHD was (55.30±13.13) years, the average dialysis age was 48 (32, 84) months, and the prevalence of anaemia was 58.2%. The prevalence of hypertension, ferritin and parathyroid hormone (PTH) in anemia group were higher than those in non-anemia group (all P < 0.05), and albumin, Ca2+, and the number of people taking α-calcidol were significantly lower than those in non-anemia group (all P < 0.05). Logistic multiple-factor analysis of single factor with statistical significance showed that hypertension and ferritin were the independent risk factors of anaemia in patients with MHD, whereas α-calciferol and Alb taken were the protective factors.   Conclusion   The condition of hypertension and high level of ferritin are the independent risk factors of anaemia in patients with MHD, whereas the nutritional status of patients and application of α-calciferol are the protective factors. Therefore, the above influencing factors should be given attention. They should be actively dealt with to reduce the incidence of renal anaemia in patients with MHD and further improve their quality of life.

     

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  • [1]
    HUANG Y M, XU D M, LONG J Y, et al. Spectrum of chronic kidney disease in China: a national study based on hospitalized patients from 2010 to 2015[J]. Nephrology(Carlton), 2019, 24(7): 725-736. http://www.onacademic.com/detail/journal_1000040459475510_3dd9.html
    [2]
    SARAN R, ROBINSON B, ABBOTT K C, et al. US renal data system 2017 annual data report: epidemiology of kidney disease in the United States[J]. Am J Kidney Dis, 2018, 71(4): 501. doi: 10.1053/j.ajkd.2018.03.001
    [3]
    LI Y, SHI H, WANG W M, et al. Prevalence, awareness, and treatment of anemia in Chinese patients with nondialysis chronic kidney disease: first multicenter, cross-sectional study[J]. Medicine, 2016, 95(24): e3872. doi: 10.1097/MD.0000000000003872
    [4]
    COVIC A, JACKSON J, HADFIELD A, et al. Real-world impact of cardiovascular disease and anemia on quality of life and productivity in patients with non-dialysis-dependent chronic kidney disease[J]. Adv Ther, 2017, 34(7): 1662-1672. doi: 10.1007/s12325-017-0566-z
    [5]
    陈颖颖, 林春华, 陈兰, 等. 维持性补铁方式对血液透析患者血红蛋白变异度的影响[J]. 中华全科医学, 2018, 16(3): 419-422. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201803027.htm
    [6]
    ZUO L, WANG M, HOU F, et al. Anemia management in the China dialysis outcomes and practice patterns study[J]. Blood Purif, 2016, 42: 33-43. doi: 10.1159/000442741
    [7]
    NI Z, JIN H, JIANG G, et al. A telemedicine-based registration system for the management of renal anemia in patients on maintenance hemodialysis: multicenter study[J]. J Med Internet Res, 2019, 21(5): e13168. doi: 10.2196/13168
    [8]
    PEREZ-GARCIA R, VARAS J, CIVES A, et al. Increased mortality in haemodialysis patients administered high doses of erythropoiesis-stimulating agents: a propensity score-matched analysis[J]. Nephrol Dial Transplant, 2018, 33(4): 690-699. doi: 10.1093/ndt/gfx269
    [9]
    DROZDZ M, WEIGERT A, SILVA F, et al. Achievement of renal anemia KDIGO targets by two different clinical strategies-a European hemodialysis multicenter analysis[J]. BMC Nephrol, 2019, 20(1): 5. doi: 10.1186/s12882-018-1196-7
    [10]
    BAHRAINWALA J, BERNS J S. Diagnosis of iron-deficiency anemia in chronic kidney disease[J]. Semin Nephrol, 2016, 36(2): 94-98. doi: 10.1016/j.semnephrol.2016.02.002
    [11]
    OGAWA C, TSUCHIYA K, TOMOSUGI N, et al. Low levels of serum ferritin and moderate transferrin saturation lead to adequate hemoglobin levels in hemodialysis patients, retrospective observational study[J]. PLoS One, 2017, 12(6): e0179608. doi: 10.1371/journal.pone.0179608
    [12]
    席春生, 蔡蕊莲, 刘同存, 等. 单中心维持性血液透析患者矿物质-骨异常的调查分析[J]. 中国中西医结合肾病杂志, 2018, 19(12): 1081-1083. doi: 10.3969/j.issn.1009-587X.2018.12.016
    [13]
    周杨洋, 汤顾航. 继发性甲状旁腺功能亢进行甲状旁腺切除术后发生重度低钙血症的相关因素分析[J]. 临床肾脏病杂志, 2018, 18(11): 710-712. doi: 10.3969/j.issn.1671-2390.2018.11.012
    [14]
    杨海明, 孟宪杰, 吴薇, 等. CKD-MBD患者血清骨代谢标记物与中医证候特征的回归分析[J]. 中国中药杂志, 2017, 42(20): 4027-4034. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY201720027.htm
    [15]
    CHEN C, WU H, ZHONG L, et al. Impacts of parathyroidectomy on renal anemia and nutritional status of hemodialysis patients with secondary hyperparathyroidism[J]. Int J Clin Exp Med, 2015, 8(6): 9830-9838. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=PMC4538062&blobtype=pdf
    [16]
    SAWALMEH O, MOALA S, HAMDAN Z, et al. Pulse versus daily oral Alfacalcidol treatment of secondary hyperparathyroidism in hemodialysis patients: a randomized controlled trial[J]. Int J Nephrol Renovasc Dis, 2018, 11: 25-32. doi: 10.2147/IJNRD.S149877
    [17]
    SANTOS E J F, HORTEGAL E V, SERRA H O, et al. Epoetin alfa resistance in hemodialysis patients with chronic kidney disease: a longitudinal study[J]. Braz J Med Biol Res, 2018, 51(7): e7288. doi: 10.1590/1414-431x20187288
    [18]
    蒲蕾, 阮一哲, 洪大情, 等. 维持性血液透析患者对红细胞生成素低反应性的影响因素[J]. 中国血液净化, 2016, 15(3): 149-153. doi: 10.3969/j.issn.1671-4091.2016.03.007
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