Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 812-816
XU Jie, GAO Long-fei, DENG Zhao-ya, LIU Jian. Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(5): 812-816. doi: 10.16766/j.cnki.issn.1674-4152.001924
Citation: XU Jie, GAO Long-fei, DENG Zhao-ya, LIU Jian. Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(5): 812-816. doi: 10.16766/j.cnki.issn.1674-4152.001924
shu

Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma

doi: 10.16766/j.cnki.issn.1674-4152.001924

  • Department of Oncology and Gynaecology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0363

  • Received Date: 2020-08-06
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the pathological characteristics, prognostic factors and differences among patients with ⅠB1 and ⅡA2 cervical squamous cell carcinoma (SCC) and cervical adenocarcinoma (AC).  Methods  To retrospectively analyse the clinical data of 260 patients with stages ⅠB1 and ⅡA2 cervical SCC or AC who underwent radical resection of cervical cancer in the First Affiliated Hospital of Bengbu Medical College from January 2016 to January 2019. The differences in pathological characteristics, prognostic factors and between the two pathological types were compared.  Results  SCC was mainly the lettuce flower type, whereas AC was primarily the endogenous infiltrating type (all P < 0.05). Differences in age, tumour size, depth of invasion and cell differentiation between the two pathological types were not statistically significant. The 3-year progression-free survival (PFS) of stages ⅠB1 and ⅡA2 cervical SCC and AC was 94.6% and 89.4%, respectively, and the difference was not statistically significant. Log-rank analysis revealed that the clinical stage, tumour size and depth of invasion were all influencing factors on the prognosis of these two pathological types. Further analysis of the prognostic factors found no statistically significant difference in tumour size, depth of invasion and clinical stage among patients with stages ⅠB1 and ⅡA2 cervical SCC and AC at 3 years. Incorporating multiple predictors of survival such as clinical stage, tumour size and depth of invasion into Multivariable Cox regression analysis the result demonstrated that clinical stage was an independent risk factor for the prognosis of patients with stages ⅠB1 and ⅡA2 SCC and AC (all P < 0.05).  Conclusion  The pathological characteristics of stages ⅠB1 and ⅡA2 cervical SCC and AC are roughly similar. AC is mainly of endogenous infiltration type, and thus it can be easily missed. Endocervical curettage can substantially reduce the missed diagnosis rate of AC. In the presence of intermediate risk factors and with the conduct of appropriate a adjuvant therapy, after surgery the patients with stages ⅠB1 and ⅡA2 SCC and AC can achieve the same prognosis.

     

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    • References(24)
  • [1]
    刘萍. 中国大陆13年宫颈癌临床流行病学大数据评价[J]. 中国实用妇科与产科杂志, 2018, 34(1): 41-45. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSF201801014.htm
    [2]
    YOKOI E, MABUCHI S, TAKAHASHI R, et al. Impact of histological subtype on survival in patients with locally advanced cervical cancer that were treated with definitive radiotherapy: adenocarcinoma/adenosquamous carcinoma versus squamous cell carcinoma[J]. J Gynecol Oncol, 2017, 28(2): e19. doi: 10.3802/jgo.2017.28.e19
    [3]
    CAO L, WEN H, FENG Z, et al. Distinctive clinicopathologic characteristics and prognosis for different histologic subtypes of early cervical cancer[J]. Int J Gynecol Cancer, 2019, 29(8): 1244-1251. doi: 10.1136/ijgc-2019-000556
    [4]
    XIE X, SONG K, CUI B, et al. A comparison of the prognosis between adenocarcinoma and squamous cell carcinoma in stage IB-IIA cervical cancer[J]. Int J Clin Oncol, 2018, 23(3): 522-531. doi: 10.1007/s10147-017-1225-8
    [5]
    胡君, 郑佩孜, 朱丽荣. ⅠB1期宫颈腺癌和鳞癌患者保留卵巢的临床病理特征比较[J]. 北京大学学报(医学版), 2016, 48(5): 783-787. doi: 10.3969/j.issn.1671-167X.2016.05.006
    [6]
    WINER I, ALVARADO-CABRERO I, HASSAN O, et al. The prognostic significance of histologic type in early stage cervical cancer-A multi-institutional study [J]. Gynecol Oncol, 2015, 137(3): 474-478. doi: 10.1016/j.ygyno.2015.02.005
    [7]
    王一琳, 吴霞, 狄文. 宫颈腺癌与宫颈鳞癌的临床特征分析[J]. 实用妇产科杂志, 2015, 31(2): 150-152. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ201502028.htm
    [8]
    陈倩莹, 刘立峰, 金仙玉. 阴道镜诊断CIN的准确性及漏诊宫颈癌的相关因素分析[J]. 大连医科大学学报, 2019, 41(4): 325-328. https://www.cnki.com.cn/Article/CJFDTOTAL-DLYK201904013.htm
    [9]
    米兰, 颛佳, 张岱, 等. 阴道镜下宫颈管搔刮术对宫颈高级别病变检出的作用[J]. 中国妇产科临床杂志, 2019, 20(2): 128-131. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC201902013.htm
    [10]
    郭艳会, 强金伟. 磁共振扩散相关成像技术在宫颈癌诊治中的研究进展[J]. 中国医学计算机成像杂志, 2020, 26(1): 93-96. doi: 10.3969/j.issn.1006-5741.2020.01.021
    [11]
    朱林林, 王海燕, 颜宪书, 等. 超声造影与核磁共振成像对宫颈癌病灶和侵犯程度评估的一致性[J]. 中华全科医学, 2019, 17(11): 1889-1892. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201911027.htm
    [12]
    SAIDA T, SAKATA A, TANAKA Y O, et al. Clinical and MRI characteristics of uterine cervical adenocarcinoma: Its variants and mimics [J]. Korean J Radiol, 2019, 20(3): 364-377. doi: 10.3348/kjr.2018.0458
    [13]
    WU S G, SUN J Y, HE Z Y, et al. Early-stage node negative cervical adenocarcinoma and squamous cell carcinoma show similar survival outcomes after hysterectomy: a population-based study[J]. J Gynecol Oncol, 2017, 28(6): e81. doi: 10.3802/jgo.2017.28.e81
    [14]
    ZHOU J, ZHANG W W, WU S G, et al. The prognostic value of histologic subtype in node-positive early-stage cervical cancer after hysterectomy and adjuvant radiotherapy[J]. Int J Surg, 2017, 44: 1-6. doi: 10.1016/j.ijsu.2017.05.074
    [15]
    CHEN J, WANG R, ZHANG B, et al. Safety of ovarian preservation in women with stage I and II cervical adenocarcinoma: a retrospective study and meta-analysis [J]. Am J Obstet Gynecol, 2016, 215(4): 460. e1-e13. doi: 10.1016/j.ajog.2016.04.023
    [16]
    KATO T, WATARI H, TAKEDA M, et al. Multivariate prognostic analysis of adenocarcinoma of the uterine cervix treated with radical hysterectomy and systematic lymphadenectomy[J]. J Gynecol Oncol, 2013, 24(3): 222-228. doi: 10.3802/jgo.2013.24.3.222
    [17]
    乌守恒, 曾晓峰, 王萍, 等. 宫颈癌组织中c-myc、bcat1的表达及其临床意义[J]. 四川大学学报(医学版), 2018, 49(5): 725-730. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYK201805008.htm
    [18]
    葛莉莉, 叶春萍, 余宁珠. 宫颈鳞癌及腺癌手术患者淋巴结分布及转移的特点差异分析[J]. 中国妇产科临床杂志, 2017, 18(5): 395-397. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC201705004.htm
    [19]
    贾海清, 王安娜, 龙再秋. 早期子宫颈腺癌预后影响因素分析[J]. 中国实用妇科与产科杂志, 2019, 35(12): 1374-1378. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSF201912023.htm
    [20]
    BHATLA N, DENNY L. FIGO Cancer Report 2018[J]. Int J Gynaecol Obstet, 2018, 143(Suppl 2): 2-3.
    [21]
    HU K, WANG W, LIU X, et al. Comparison of treatment outcomes between squamous cell carcinoma and adenocarcinoma of cervix after definitive radiotherapy or concurrent chemoradiotherapy[J]. Radiat Oncol, 2018, 13(1): 249. doi: 10.1186/s13014-018-1197-5
    [22]
    HOU Y, GUO S, LYU J, et al. Prognostic factors in Asian and white American patients with cervical cancer, considering competing risks[J]. Curr Oncol, 2019, 26(3): 277-285. doi: 10.3747/co.26.4473
    [23]
    黄裕, 雷海科, 陈文娟, 等. 老年宫颈癌患者治疗结局及预后分析[J]. 中华肿瘤防治杂志, 2018, 25(6): 428-432. https://www.cnki.com.cn/Article/CJFDTOTAL-QLZL201806010.htm
    [24]
    MABUCHI Y, YAHATA T, KOBAYASHI A, et al. Clinicopathologic factors of cervical adenocarcinoma stages IB to IIB[J]. Int J Gynecol Cancer, 2015, 25(9): 1677-1682. doi: 10.1097/IGC.0000000000000542
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