Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma

XU Jie; GAO Long-fei; DENG Zhao-ya; LIU Jian

doi:10.16766/j.cnki.issn.1674-4152.001924

Volume 19 Issue 5

May 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(5): 812-816

XU Jie, GAO Long-fei, DENG Zhao-ya, LIU Jian. Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(5): 812-816. doi: 10.16766/j.cnki.issn.1674-4152.001924

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XU Jie, GAO Long-fei, DENG Zhao-ya, LIU Jian. Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(5): 812-816. doi: 10.16766/j.cnki.issn.1674-4152.001924

Citation:

XU Jie, GAO Long-fei, DENG Zhao-ya, LIU Jian. Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(5): 812-816. doi: 10.16766/j.cnki.issn.1674-4152.001924

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Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma

doi: 10.16766/j.cnki.issn.1674-4152.001924

Department of Oncology and Gynaecology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

KJ2019A0363

Received Date: 2020-08-06
Available Online: 2022-02-16

Abstract

Abstract

Objective To explore the pathological characteristics, prognostic factors and differences among patients with ⅠB1 and ⅡA2 cervical squamous cell carcinoma (SCC) and cervical adenocarcinoma (AC). Methods To retrospectively analyse the clinical data of 260 patients with stages ⅠB1 and ⅡA2 cervical SCC or AC who underwent radical resection of cervical cancer in the First Affiliated Hospital of Bengbu Medical College from January 2016 to January 2019. The differences in pathological characteristics, prognostic factors and between the two pathological types were compared. Results SCC was mainly the lettuce flower type, whereas AC was primarily the endogenous infiltrating type (all P < 0.05). Differences in age, tumour size, depth of invasion and cell differentiation between the two pathological types were not statistically significant. The 3-year progression-free survival (PFS) of stages ⅠB1 and ⅡA2 cervical SCC and AC was 94.6% and 89.4%, respectively, and the difference was not statistically significant. Log-rank analysis revealed that the clinical stage, tumour size and depth of invasion were all influencing factors on the prognosis of these two pathological types. Further analysis of the prognostic factors found no statistically significant difference in tumour size, depth of invasion and clinical stage among patients with stages ⅠB1 and ⅡA2 cervical SCC and AC at 3 years. Incorporating multiple predictors of survival such as clinical stage, tumour size and depth of invasion into Multivariable Cox regression analysis the result demonstrated that clinical stage was an independent risk factor for the prognosis of patients with stages ⅠB1 and ⅡA2 SCC and AC (all P < 0.05). Conclusion The pathological characteristics of stages ⅠB1 and ⅡA2 cervical SCC and AC are roughly similar. AC is mainly of endogenous infiltration type, and thus it can be easily missed. Endocervical curettage can substantially reduce the missed diagnosis rate of AC. In the presence of intermediate risk factors and with the conduct of appropriate a adjuvant therapy, after surgery the patients with stages ⅠB1 and ⅡA2 SCC and AC can achieve the same prognosis.
- ⅠB1 and ⅡA2 Stage,
- Cervical squamous cell carcinoma,
- Cervical adenocarcinoma,
- Pathological characteristics,
- Prognosis

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References

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Analysis of pathological characteristics and prognosis of stages ⅠB1 and ⅡA2 cervical squamous cell carcinoma and adenocarcinoma

doi: 10.16766/j.cnki.issn.1674-4152.001924