Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 756-759
SU Kui-wei, LI Xiao, CHENG Gang. The relationship between the expression of HYAL1 and the progression and prognosis of head and neck squamous cell carcinoma[J]. Chinese Journal of General Practice, 2021, 19(5): 756-759. doi: 10.16766/j.cnki.issn.1674-4152.001909
Citation: SU Kui-wei, LI Xiao, CHENG Gang. The relationship between the expression of HYAL1 and the progression and prognosis of head and neck squamous cell carcinoma[J]. Chinese Journal of General Practice, 2021, 19(5): 756-759. doi: 10.16766/j.cnki.issn.1674-4152.001909
shu

The relationship between the expression of HYAL1 and the progression and prognosis of head and neck squamous cell carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.001909
  • 1.

    Graduate School of Bengbu Medical College, Bengbu, Anhui 233030, China

Funds:

 KJ2016A480

  • Received Date: 2020-09-21
    Available Online: 2022-02-16
    Abstract
  •   Objective  This article aims to study the expression level of hyaluronidase 1 (HYAL1) in head and neck squamous cell carcinoma (HNSCC) and its relationship with the survival of HNSCC patients.  Methods  The data of HNSCC patients who underwent radical resection in Zhejiang Provincial People's Hospital from 2008 to 2015 were collected to construct tissue chips, and the expression of HYAL1 in tumor specimens and nearby tissues from 258 patients was detected by immunohistochemistry.  Results  The expression of HYAL1 in HNSCC tissues was significantly lower than that of normal adjacent tissues (P < 0.001). The low expression of HYAL1 was significantly correlated with tumor size (P=0.011), lymph node metastasis (P=0.025) and TNMs staging system (P=0.038). In addition, compared with high HYAL1 expression, low HYAL1 expression was significantly associated with short survival time (P=0.007). The median overall survival of patients with low HYAL1 expression is 36 months, while the median overall survival of patients with high HYAL1 expression has not yet reached (more than 74 months). It is worth noting that in our limited cases, this study did not find any difference in age, gender, lesion site, HPV infection, smoking, drinking, and histological staging between the patients with high low expression of HYAL1.  Conclusion  The low expression of HYAL1 is related to the poor prognosis of these HNSCC patients. HYAL1 may be a clinically valuable prognostic indicator and a potential target for HNSCC treatment.

     

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