Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 723-726, 808
YAO Yu-ting, XU Qi-xia, PANG Ying-ying, ZHOU Yue, WANG Yue-yue. Analysis of clinical characteristics of malignant tumors complicated with venous thromboembolism and evaluation of predictive models[J]. Chinese Journal of General Practice, 2021, 19(5): 723-726, 808. doi: 10.16766/j.cnki.issn.1674-4152.001901
Citation: YAO Yu-ting, XU Qi-xia, PANG Ying-ying, ZHOU Yue, WANG Yue-yue. Analysis of clinical characteristics of malignant tumors complicated with venous thromboembolism and evaluation of predictive models[J]. Chinese Journal of General Practice, 2021, 19(5): 723-726, 808. doi: 10.16766/j.cnki.issn.1674-4152.001901
shu

Analysis of clinical characteristics of malignant tumors complicated with venous thromboembolism and evaluation of predictive models

doi: 10.16766/j.cnki.issn.1674-4152.001901

  • Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2016YFC0905600

  • Received Date: 2020-11-23
    Available Online: 2022-02-16
    Abstract
  •   Objective  The aim of this study was to investigate the clinical characteristics of malignant tumors complicated with venous thromboembolism (VTE) and verify the predictive value of COMPASS-CAT and Khorana score.   Methods  A total of 128 patients who were diagnosed with malignant tumors and VTE in the First Affiliated Hospital of Bengbu Medical College from January 2016 to January 2020 were collected as the VTE group, and a total of 256 patients with malignant tumor without VTE matched by age, sex and tumor type were selected as the control group. Logistic regression model was used to analyze the risk factors of VTE. The predictive value of COMPASS-CAT and Khorana risk score (KRS) for venous thromboembolism in cancer patients was compared, to construct a more effective predictive model to guide thrombosis prevention in patients with malignant tumors.   Results  (1) D-dimer>0.55 mg/L, central venous catheter, and cardiovascular risk factors were high risk factors for VTE in patients with malignant tumors (P values were less than 0.05). (2) The proportion of COMPASS-CAT score≥7 was statistically significant between the VTE group and the control group (P < 0.001). The probability was 4.051 times higher in high risk patients than in low risk patients by COMPASS-CAT score. There was no statistically significant difference in the proportion of Khorana score≥3 points in the VTE group and the control group (P>0.05). The area under ROC curve (AUC) of COMPASS-CAT score was higher than that of Khorana score (AUC: 0.670 vs. 0.583, P < 0.05). (3) On the basis of COMPASS-CAT score, including D-dimer>3.83 mg/L to a joint prediction model was constructed, its AUC was 0.879. Compared with the COMPASS-CAT score, the AUC of the joint prediction model increased by 0.209, and the difference was statistically significant (P < 0.001).   Conclusion  The COMPASS-CAT score can better predict the risk of VTE in patients with malignant tumors, while the KRS has limited predictive value. Combining COMPASS-CAT score and D-dimer>3.83 mg/L to construct a new prediction model can improve the prediction performance of malignant tumor-related VTE.

     

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