Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 715-718,829
LIU Chu-chu, HUANG Jie, LIU Yu-hui, ZHOU Hua-dong, XU Li. Risk factors and recurrence characteristics of neuromyelitis optica spectrum disease[J]. Chinese Journal of General Practice, 2021, 19(5): 715-718,829. doi: 10.16766/j.cnki.issn.1674-4152.001899
Citation: LIU Chu-chu, HUANG Jie, LIU Yu-hui, ZHOU Hua-dong, XU Li. Risk factors and recurrence characteristics of neuromyelitis optica spectrum disease[J]. Chinese Journal of General Practice, 2021, 19(5): 715-718,829. doi: 10.16766/j.cnki.issn.1674-4152.001899
shu

Risk factors and recurrence characteristics of neuromyelitis optica spectrum disease

doi: 10.16766/j.cnki.issn.1674-4152.001899
  • 1.

    Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 81771177

 cstc2018jcyjAX0511

  • Received Date: 2020-11-30
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the risk factors and recurrence characteristics of neuromyelitis optica spectrum disease (NMOSD) through a case study.   Methods  Total 204 NMOSD patients diagnosed in the Department of Neurology of the First Affiliated Hospital of Bengbu Medical College and the Department of Neurology of Chongqing Army Characteristic Medical Center were included from January 2016 to August 2017. There were 54 males and 150 females, with an average age of 37.5 years. There were 818 cases in the control group, which matched the age of the NMOSD group. Patients' general clinical data and serum AQP4-IgG levels were collected, and related factors were analysed.   Results  Multivariate analysis found that women with a history of exertion and patients with previous autoimmune diseases increased the risk more than 2 times (OR=2.473, 95% CI: 1.714-3.486; OR=2.319, 95% CI: 1.573-3.349; OR=2.210, 95% CI: 1.001-4.740). For people with low income level, history of upper respiratory tract infection, history of gynaecological surgery/obstetric surgery, alcohol consumption, the risk of patients with history and trauma surgery increased by more than 1.5 times (OR=1.502, 95% CI: 1.020-2.121; OR=1.651, 95% CI: 1.121-2.382; OR=1.712, 95% CI: 1.060-3.375; OR=1.830, 95% CI: 1.011-3.184; OR=1.928, 95% CI: 1.032-3.516).   Conclusion  Economic income level, history of fatigue, history of upper respiratory tract infection, history of gynaecological surgery/obstetric surgery, history of trauma surgery, history of drinking and other autoimmune diseases may be risk factors for NMOSD to a certain extent. Recurrence of NMOSD patients may lead to more severe clinical symptoms, imaging findings and worse prognosis.

     

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    • References(23)
  • [1]
    CHEN H, LIU S M, ZHANG X X, et al. Clinical features of patients with multiple sclerosis and neuromyelitis optica spectrum disorders[J]. Chin Med J (Engl), 2016, 129(17): 2079-2084. doi: 10.4103/0366-6999.189046
    [2]
    WINGERCHUK D M, BANWELL B, BENNETT J L, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders[J]. Neurology, 2015, 85(2): 177-189. doi: 10.1212/WNL.0000000000001729
    [3]
    HOUZEN H, KONDO K, NⅡNO M, et al. Prevalence and clinical features of neuromyelitis optica spectrum disorders in northern Japan[J]. Neurology, 2017, 89(19): 1995-2001. doi: 10.1212/WNL.0000000000004611
    [4]
    JIAO Y, FRYER J P, LENNON V A, et al. Updated estimate of AQP4-IgG serostatus and disability outcome in neuromyelitis optica[J]. Neurology, 2013, 81(14): 1197-1204. doi: 10.1212/WNL.0b013e3182a6cb5c
    [5]
    VISWANATHAN S, WAH L M. A nationwide epidemiological study on the prevalence of multiple sclerosis and neuromyelitis optica spectrum disorder with important multi-ethnic differences in Malaysia[J]. Mult Scler, 2019, 25(11): 1452-1461. doi: 10.1177/1352458518792430
    [6]
    SUN H, SUN X, LI J, et al. Gender differences among Chinese patients with neuromyelitis optica spectrum disorders[J]. Mult Scler Relat Disord, 2017, 17: 5-8. doi: 10.1016/j.msard.2017.06.008
    [7]
    PALACE J, LIN D Y, ZENG D, et al. Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders[J]. Brain, 2019, 142(5): 1310-1323. doi: 10.1093/brain/awz054
    [8]
    KUNCHOK A, MALPAS C, NYTROVA P, et al. Clinical and therapeutic predictors of disease outcomes in AQP4-IgG+ neuromyelitis optica spectrum disorder[J]. Mult Scler Relat Disord, 2020, 38: 101868. doi: 10.1016/j.msard.2019.101868
    [9]
    AKAISHI T, TAKAHASHI T, FUJIHARA K, et al. Risk factors of attacks in neuromyelitis optica spectrum disorders[J]. J Neuroimmunol, 2020, 343: 577236. doi: 10.1016/j.jneuroim.2020.577236
    [10]
    HOR J Y, ASGARI N, NAKASHIMA I, et al. Epidemiology of neuromyelitis optica spectrum disorder and its prevalence and incidence worldwide[J]. Front Neurol, 2020, 11: 501. doi: 10.3389/fneur.2020.00501
    [11]
    WINGERCHUK D M, HOGANCAMP W F, O'BRIEN P C, et al. The clinical course of neuromyelitis optica (Devic's syndrome)[J]. Neurology, 1999, 53(5): 1107. doi: 10.1212/WNL.53.5.1107
    [12]
    MEALY M A, MOSSBURG S E, KIM S H, et al. Long-term disability in neuromyelitis optica spectrum disorder with a history of myelitis is associated with age at onset, delay in diagnosis/preventive treatment, MRI lesion length and presence of symptomatic brain lesions[J]. Mult Scler Relat Disord, 2019, 28: 64-68. doi: 10.1016/j.msard.2018.12.011
    [13]
    RAFIEE F, TARJOMAN T, MOGHADASI A N, et al. Stressful life events, socioeconomic status, and the risk of neuromyelitis optica spectrum disorder: A population-based case-control study[J]. Mult Scler Relat Disord, 2020, 46: 102544. doi: 10.1016/j.msard.2020.102544
    [14]
    ABDOLLAHPOUR I, NEDJAT S, SAHRAIAN M A, et al. Waterpipe smoking associated with multiple sclerosis: A population-based incident case-control study[J]. Mult Scler, 2017, 23(10): 1328-1335. doi: 10.1177/1352458516677867
    [15]
    ETEMADI A, KHADEMI H, KAMANGAR F, et al. Hazards of cigarettes, smokeless tobacco and waterpipe in a Middle Eastern Population: a Cohort Study of 50000 individuals from Iran[J]. Tob Control, 2017, 26(6): 674-682. doi: 10.1136/tobaccocontrol-2016-053245
    [16]
    KLAWITER E C, BOVE R, ELSONE L, et al. High risk of postpartum relapses in neuromyelitis optica spectrum disorder[J]. Neurology, 2017, 89(22): 2238-2244. doi: 10.1212/WNL.0000000000004681
    [17]
    TONG Y, LIU J, YANG T, et al. Influences of pregnancy on neuromyelitis optica spectrum disorders and multiple sclerosis[J]. Mult Scler Relat Disord, 2018, 25: 61-65. doi: 10.1016/j.msard.2018.07.006
    [18]
    FRAGOSO Y D, SOUSA N A C, ALVES-LEON S V, et al. Clinical characteristics of 153 Brazilian patients with neuromyelitis optica spectrum disorder[J]. Mult Scler Relat Disord, 2019, 27: 392-396. doi: 10.1016/j.msard.2018.11.031
    [19]
    CHANG V T W, CHANG H M. Review: Recent advances in the understanding of the pathophysiology of neuromyelitis optica spectrum disorder[J]. Neuropathol Appl Neurobiol, 2020, 46(3): 199-218. doi: 10.1111/nan.12574
    [20]
    ZHANG W, CUI L, ZHANG Y, et al. Questioning the existence of monophasic neuromyelitis optica spectrum disorder by defining a novel long-term relapse-free form from a large Chinese population[J]. J Neurol, 2020, 267(4): 1197-1205. doi: 10.1007/s00415-019-09685-3
    [21]
    JARIUS S, RUPRECHT K, WILDEMANN B, et al. Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: a multicentre study of 175 patients[J]. J Neuroinflammation, 2012, 9(1): 14. doi: 10.1186/1742-2094-9-14
    [22]
    陈彧, 赵建民, 王夏红, 等. 视神经脊髓炎的视觉诱发电位和MRI对照研究[J]. 眼科新进展, 2008, 28(9): 698-699. https://www.cnki.com.cn/Article/CJFDTOTAL-XKJZ200809030.htm
    [23]
    MA X, KERMODE A G, HU X, et al. Risk of relapse in patients with neuromyelitis optica spectrum disorder: Recognition and preventive strategy[J]. Mult Scler Relat Disord, 2020, 46: 102522. doi: 10.1016/j.msard.2020.102522
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