Volume 17 Issue 11
Aug.  2022
Turn off MathJax
Article Contents
LIU Bing-wei, HU Wei, ZHU Ying, WANG Jian-rong, ZENG Xiao-kang. Clinical value of pro-BNP and cTnI in patients with sepsis related myocardial injury[J]. Chinese Journal of General Practice, 2019, 17(11): 1815-1817,1844. doi: 10.16766/j.cnki.issn.1674-4152.001063
Citation: LIU Bing-wei, HU Wei, ZHU Ying, WANG Jian-rong, ZENG Xiao-kang. Clinical value of pro-BNP and cTnI in patients with sepsis related myocardial injury[J]. Chinese Journal of General Practice, 2019, 17(11): 1815-1817,1844. doi: 10.16766/j.cnki.issn.1674-4152.001063

Clinical value of pro-BNP and cTnI in patients with sepsis related myocardial injury

doi: 10.16766/j.cnki.issn.1674-4152.001063
  • Received Date: 2018-02-28
  • Objective The mortality in sepsis patients with myocardial injury is high, and the early diagnosis is of great significance. The aim of this paper is to discuss the application of Pro-BNP and cTnI in patients with sepsis induced myocardial injury. Methods From February 2016 to August 2017, 40 patients with sepsis related myocardial injury in Department of Critical Care Medicine of Hangzhou First People's Hospital were recruited. According to left ventricular ejection fraction (LVEF) after admission, the patients were divided into LVEF>40% group (23 cases) and LVEF≤40% group (17 cases); Likewise, according to the prognosis, the patients were divided into survival group (24 cases) and death group (16 cases). The levels of Pro-BNP, cTnI and lactic acid were measured, APACHE Ⅱ score was recorded; LVEDD was measured by echocardiography, dp/dt max was monitored by PiCCO. The area under the ROC curve was used to analyze the prognostic value of Pro-BNP and cTnI in patients with sepsis related myocardial injury. The correlation among Pro-BNP, cTnI and LVEF were also analyzed. Results The Pro-BNP, cTnI, lactic acid, LVEDD, APACHEⅡ scores in the LVEF>40% group were all less than those in the LVEF≤40% group, and the dp/dt max was greater than the LVEF≤40% group, the difference was statistically significant; The Pro-BNP, cTnI, lactic acid, and APACHEII scores of the survival group were lower than those of the death group. The dp/dt max of the survival group was greater than that of the death group, and the differences were statistically significant. For prediction of prognosis in patients with sepsis myocardial injury, the sensitivity of Pro-BNP was 0.82, specificity was 0.80, an area under the ROC curve of 0.88; the sensitivity of cTnI was 0.93, specificity was 0.88, and the area under the ROC curve was 0.96. There was a negative correlation between Pro-BNP, cTnI and LVEF (r=-0.360, P=0.023; r=-0.315, P=0.048). Conclusion Both Pro-BNP and cTnI increases in the patients with sepsis related myocardial injury, the increase of pro-BNP and cTnI may correlate with poor prognosis.

     

  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (230) PDF downloads(1) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return