Abstract: Objective To study the application of evidence-based nursing(EBN) in the treatment of nasal polyps. Methods Total 320 cases of nasal polyps from June,2015 to June,2016 in our hospital were divided into drug treatment group(196 cases) and surgical treatment group(124 cases),and each group was divided into 2 sub-groups according to the nursing methods (drug treatment group 1 and 2,surgical treatment group 1 and 2).Drug treatment group 1 and surgical treatment group 1 were given routine nursing care during therapy,while the drug treatment group 2 and surgical treatment group 2 were given evidence based nursing model during therapy.The changes of negative emotions on admission and at discharge were observed in all groups,the degree of mastering disease knowledge,satisfactory degree of nursing and the treatment effect of the patients were evaluated. Results There were significant decreases in self-rating depression scale and self-rating anxiety scale scores decreased prominently at discharge than those on admission,which were obviously lower in the evidence based nursing group as compared with the routine nursing group(P<0.05).At discharge,the degree of mastering disease knowledge and satisfactory degree of nursing in the evidence based nursing group was apparently higher than those in the routine nursing group(P<0.05).The treatment efficiency with evidence based nursing model were significantly higher than that of the routine nursing model in both drug treatment group(drug treatment group 1 and 2) and surgical treatment group(surgical treatment group 1 and 2). Conclusion Evidence-based nursing model possess good effect and high clinical value in the clinical treatment of patients with nasal polyps.