Abstract: Objective Endometrial polyp is a common gynecological disease.Transcervical resection of polyps (TCRP) is an effective treatment for endometrial polyp;however, the recurrence rate was higher.Therefore, how to prevent the recurrence of endometrial polyp was the purpose of this research.The aim of this paper is to investigate the changes of E2 and P levels in blood, and ER and PR in endometrium before and after the Huayu Sanjie therapy in in patients with endometrial polyp after TCRP. Methods Total 147 cases of endometrial polyp (blood stasis type by TCM, confirmed by hysteroscopy and histopathologic examination) undergoing TCRP in our hospital between June, 2015 and June, 2016 were randomly divided into traditional Chinese medicine group, western medicine group and control group with 49 cases in each group.The traditional Chinese medicine group received Huayu Sanjie therapy and the western medicine group received Marvelon therapy for 3 months.The changes of E2 and P levels in blood, and ER and PR levels in endometrium before and after treatment were compared. Results There was no obvious change in the levels of E2, P and ER in all three groups after the treatment.The expression of PR was up-regulated both in the Chinese medicine group and the western medicine group, and especially obvious in the Chinese medicine treatment group (P < 0.05). Conclusion Huayu Sanjie therapy may improve the endometrial blood flow, and regulate the distribution of PR in endometrium, and up-regulate the expression of PR in patients with endometrial polyp, promote the uterine lining to shed completely and periodically, then to inhibit the recurrence of endometrial polyp.