Abstract: Objective To evaluate the clinical efficacy of enalapril combined with folic acid in the treatment of H type hypertension and its influence on vascular endothelial function. Methods From October,2014 to October,2015,170 cases of H type hypertension patients in our hospital were selected and randomly divided into the observation group and the control group (85 cases in each group);The control group were given enalapril maleate tablets,while the observation group had folic acid tablets on basis of the control group;Before and 24 w after the treatment,the 24 h ambulatory blood pressure,the levels of Hcy,sICAM-1,IMT,ET-1 and NO were tested and compared. Results After the treatment,24hSBP,24hDBP,dSBP,dDBP,nSBP,nDBP,24hSBPV,24hDBPV,dSBPV,dDBPV,nSBPV and nDBPV were all significantly decreased in both groups (P<0.05),more significantly in the observation group (P<0.05).After the treatment,the levels of Hcy,sICAM-1,NO,ET-1 and IMT were (7.4±2.9)μmol/L,(342.4±39.5)μg/L,(78.4±9.1)μmol/L,(53.4±9.6) ng/L and (1.0±0.6) mm,respectively,which were obviously superior to the control group[(9.2±3.0)μmol/L,(366.5±39.5)μg/L,(75.3±8.0)μmol/L,(57.4±9.8) ng/L and (1.3±0.6) mm,respectively],the difference was statistically significant (P<0.05). Conclusion Enalapril combined with folic acid can improve blood pressure and blood pressure variability in patients with H-type hypertension,which could delay the process of atherosclerosis and improve vascular endothelial function,worthy of clinical promotion.