Abstract: Objective To investigate the analysis of adrenocortical carcinoma (adrenocortical,carcinomas,ACC) patients underwent radical resection related influencing the postoperative long-term survival rate and the factors for clinical reference increased mortality risk discriminant factors. Methods A retrospective analysis of Jinhua People's Hospital from January,2005 to January,2010 in Zhejiang during the biopsy confirmed the clinical data of 18 ACC patients ACC parallel radical resection of the adrenal gland,analysis and application of Cox proportional hazard model for single factor,calculate the patient survival rate by Kaplan-Meier method,compared the survival rate by log-rank method,analysis of the long-term prognosis and effect of patients prognostic factors. Results The median age of the patients was 48 years (23-67 years).Eighteen patients were followed up for a median of 75 months (3-165 months),with a mean of 3,5-and 10 year survival rates of 55.5%,44.4%,and 16.7%,respectively.The median survival time was 46 months (1-158 months).Univariate analysis showed that the degree of tumor infiltration and lymph node metastasis (P=0.02,0.01) were related to the long-term prognosis,and the disease-free survival rates of the patients at 3,5 and 10 years were about 55.5%,33.3%,respectively.Single factor analysis showed that the degree of tumor infiltration and lymph node metastasis were also associated with tumor free survival (P<0.01,P=0.03). Conclusion Radical resection can provide an opportunity for ACC,and the degree of tumor infiltration and lymph node metastasis are important factors affecting the prognosis of patients with ACC.