Abstract: Objective Problem-Based Learning (PBL),created by Howard Barrow who was an American professor of neurology in McMaster university in Canada in 1969,is a very popular teaching model all around the world.The core of PBL is "student-centered,problem-based",it targeted at "autonomic learning,lifelong learning",PBL has been generalized and applied popularly in academic activity since it had been introduced in nursing education 1970s.This article is to explore application of PBL model in nursing bilingual teaching,for the purpose of consideration and recommendation could be made for medical college to introduce PBL to nursing bilingual teaching. Methods On basis of theoretical and practical study on PBL teaching model from oversea and abroad,as well as the purpose of extending and deepening reform direction and characteristic of nursing bilingual teaching,the study focus on application of PBL model in nursing bilingual teaching. Results In consideration of current educational background,as well as integrating native and foreign PBL model into medical education,some problems have been identified for application of PBL model in terms of learner,learning instructor,learning tools and learning environment,in order to explore new model of independent and cooperative nursing bilingual teaching which is adaptable to the need of medical college. Conclusion Consideration has been taken to cultivate traditional teaching method,formulate teaching training program,compile bilingual teaching textbook,enhance hardware construction,in order to widen and intensify nursing bilingual teaching based on characteristic of nursing science in new era.